22 research outputs found
Pathological features of transplanted tumor established by CD133 positive TJ905 glioblastoma stem-like cells
INTEGRATED ANALYSIS IDENTIFIES DIFFERENT METABOLIC SIGNATURES WITHIN BOTH TUMOR-INITIATING CELLS AND STEM CELLS IN A MURINE GLIOBLASTOMA MODEL
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
10.1038/s41467-017-02287-5Nature Communications81220
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
The Ras/Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways are essential for cancer cell survival. Here, the authors describes a molecule a131 with dual-inhibitory properties, which targets PI5P4K and mitosis, and it is involved in Ras/Raf/MEK/ERK and PI3K/Akt/mTOR crosstalk, thereby causing reversible growth arrest in normal cells and cell death of tumor cells
Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival
Tumor Invasion Optimization by Mesenchymal-Amoeboid Heterogeneity
Metastasizing tumor cells migrate through the surrounding tissue and extracellular matrix toward the blood vessels, in order to colonize distant organs. They typically move in a dense environment, filled with other cells. In this work we study cooperative effects between neighboring cells of different types, migrating in a maze-like environment with directional cue. Using a computerized model, we measure the percentage of cells that arrive to the defined target, for different mesenchymal/amoeboid ratios. Wall degradation of mesenchymal cells, as well as motility of both types of cells, are coupled to metabolic energy-like resource level. We find that indirect cooperation emerges in mid-level energy, as mesenchymal cells create paths that are used by amoeboids. Therefore, we expect to see a small population of mesenchymals kept in a mostly-amoeboid population. We also study different forms of direct interaction between the cells, and show that energy-dependent interaction strength is optimal for the migration of both mesenchymals and amoeboids. The obtained characteristics of cellular cluster size are in agreement with experimental results. We therefore predict that hybrid states, e.g. epithelial-mesenchymal, should be utilized as a stress-response mechanism