Mitigation of Quantum Dot Cytotoxicity by Microencapsulation

When CdSe/ZnS-polyethyleneimine (PEI) quantum dots (QDs) are microencapsulated in polymeric microcapsules, human fibroblasts are protected from acute cytotoxic effects. Differences in cellular morphology, uptake, and viability were assessed after treatment with either microencapsulated or unencapsulated dots. Specifically, QDs contained in microcapsules terminated with polyethylene glycol (PEG) mitigate contact with and uptake by cells, thus providing a tool to retain particle luminescence for applications such as extracellular sensing and imaging. The microcapsule serves as the “first line of defense” for containing the QDs. This enables the individual QD coating to be designed primarily to enhance the function of the biosensor

Magnetic Heating by Tunable Arrays of Nanoparticles in Cancer Therapy

Detailed knowledge about the temperature distribution achieved in the target area is essential for the development of magnetic hyperthermia treatments. However, the temperature inhomogeneity was found in all local hyperthermia studies. As a consequence of the impossibility of guaranteeing the temperature and thus the thermal dose distribution, hyperthermia is never applied as a single treatment modality. We suggest a model that enables the calculations and optimization of the spatial-time distribution of the temperature in the target volume (i.e. tumor) caused by magnetically heated elements: (i) arrays of clusters of iron oxides magnetite $(Fe_3O_4)$ magnetic nanoparticles, and (ii) arrays of magnetic needles. In order to find the spatial-time temperature distribution in tumor, the bioheat transfer equation is solved for the two above-mentioned arrays of magnetically heated sources embedded in the tumor. The temporal and spatial temperature distributions were calculated with regard to the effect of blood perfusion in the tumor. It is shown that a matrix of magnetic micro-needles injected in the tumor could provide rather uniform tumor heating with the center-edge temperature difference smaller than 3°C at any times during the magnetic hyperthermia treatments. The temperature profiles can be suitably adjusted by a proper choice of the magnetic nanoparticles arrangement

Control of Hepatic Cells Growth by Topologically Modulated Substrates

International audienc