Positional information, positional error, and read-out precision in morphogenesis: a mathematical framework

The concept of positional information is central to our understanding of how cells in a multicellular structure determine their developmental fates. Nevertheless, positional information has neither been defined mathematically nor quantified in a principled way. Here we provide an information-theoretic definition in the context of developmental gene expression patterns and examine which features of expression patterns increase or decrease positional information. We connect positional information with the concept of positional error and develop tools to directly measure information and error from experimental data. We illustrate our framework for the case of gap gene expression patterns in the early Drosophila embryo and show how information that is distributed among only four genes is sufficient to determine developmental fates with single cell resolution. Our approach can be generalized to a variety of different model systems; procedures and examples are discussed in detail

Thermally regenerable carbon dioxide absorbent system Final report, 1 May 1964 - 31 Jan. 1966

Carbon dioxide absorption by solid state ion exchange resin

Suppression of material transfer at contacting surfaces: The effect of adsorbates on Al/TiN and Cu/diamond interfaces from first-principles calculations

The effect of monolayers of oxygen (O) and hydrogen (H) on the possibility of material transfer at aluminium/titanium nitride (Al/TiN) and copper/diamond (Cu/C$_{\text{dia}}$) interfaces, respectively, were investigated within the framework of density functional theory (DFT). To this end the approach, contact, and subsequent separation of two atomically flat surfaces consisting of the aforementioned pairs of materials were simulated. These calculations were performed for the clean as well as oxygenated and hydrogenated Al and C$_{\text{dia}}$ surfaces, respectively. Various contact configurations were considered by studying several lateral arrangements of the involved surfaces at the interface. Material transfer is typically possible at interfaces between the investigated clean surfaces; however, the addition of O to the Al and H to the C$_{\text{dia}}$ surfaces was found to hinder material transfer. This passivation occurs because of a significant reduction of the adhesion energy at the examined interfaces, which can be explained by the distinct bonding situations.Comment: 27 pages, 8 figure

Numerical optimization of atmospheric reentry trajectories by the sweep method

Numerical optimization of atmospheric reentry trajectories by sweep metho

Optical Pulse Dynamics in Active Metamaterials with Positive and Negative Refractive Index

We study numerically the propagation of two-color light pulses through a metamaterial doped with active atoms such that the carrier frequencies of the pulses are in resonance with two atomic transitions in the $\Lambda$ configuration and that one color propagates in the regime of positive refraction and the other in the regime of negative refraction. In such a metamaterial, one resonant color of light propagates with positive and the other with negative group velocity. We investigate nonlinear interaction of these forward- and backward-propagating waves, and find self-trapped waves, counter-propagating radiation waves, and hot spots of medium excitation.Comment: 9 pages, 6 figure

Of clerks & cleaners: the heterogeneous impact of monetary policy on the US labor market

In this paper we estimate the effect of monetary policy on the US labor market using disaggregated data based on large scale micro surveys. By employing a Bayesian factor-augmented vector autoregression framework, we investigate the impact of an unanticipated interest rate change on the unemployment rate in 32 occupation groups. Our results on the aggregate level are in line with the literature and point towards a strong influence of monetary policy on economic activity, overall unemployment and investment. A closer look on the disaggregated level reveals heterogeneous impacts across occupation groups. This heterogeneity can partially be explained by the amount of routine tasks and the degree of offshorability of an particular occupation group. These results suggest that workers who are highly vulnerable to medium-term and long-term developments such as automatization and offshoring are also hit disproportionately hard by short-term economic fluctuations.Series: Department of Economics Working Paper Serie

MgB2 radio-frequency superconducting quantum interference device prepared by atomic force microscope lithography

A new method of preparation of radio-frequency superconducting quantum interference devices on MgB2 thin films is presented. The variable-thickness bridge was prepared by a combination of optical lithography and of the scratching by an atomic force microscope. The critical current of the nanobridge was 0.35 uA at 4.2 K. Non-contact measurements of the current-phase characteristics and of the critical current vs. temperature have been investigated on our structures.Comment: RevTeX4. Accepted in Appl. Phys. Let