Pargyline-induced increases in sensitivity to the effects of drugs on operant behavior in pigeons

Pigeons responded under a multiple fixedinterval 5-min, 30-response fixed-ratio schedule of food reinforcement. Acute pargyline doses between 10.0 and 50.0 mg/kg (i.m.), given immediately prior to the session, decreased responding. Daily administration of 50 mg/kg pargyline (24 mg/kg, every 12 h) initially decreased responding. Tolerance developed so that after 4 days of daily pargyline, responding had returned to control values. Chronic pargyline resulted in an enhanced sensitivity to the effects of d -amphetamine, ephedrine, tyramine, and morphine on schedule-controlled responding. Both d -amphetamine and pentobarbital increased fixed-interval responding at relatively low doses, while higher doses decreased responding. Daily pargyline resulted in an increased sensitivity to both the increases and decreases in response rates produced by d -amphetamine. In contrast, sensitivity to pentobarbital was not changed after daily pargyline. Ephedrine, tyramine, and morphine only decreased fixed-interval responding. Chronic pargyline resulted in an increased sensitivity to the response-rate decreasing effects of ephedrine, tyramine, and morphine. In addition to the increased sensitivity of fixed-interval responding to the effects of tyramine, the dose-effect curve for fixed-ratio responding was also a shifted to the left. Daily pargyline did not result in changes in sensitivity of fixedratio responding to the effects of the other drugs tested.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46399/1/213_2004_Article_BF00426607.pd

Expected utility, self-control, morality, and criminal probability

With data from random sample household surveys conducted simultaneously in major cities in Greece and in Russia, we evaluate the import of individuals' morality relative to expected utility and self-control in predicting criminal probability. In addition, we examine potential interactions among the three variables in predicting criminal propensity and compare their relative effects across the two samples. The results suggest that all three factors are important and mostly independent influences in explaining criminal probability. However, the estimated effects of morality are substantially stronger than those of either expected utility or self-control, and all three of these explanatory variables appear to be somewhat sensitive to cultural contexts. Overall, our findings confirm that morality plays a comparatively larger part in explaining conformity than is generally recognized by major contemporary theories, although the data cannot show whether morality is an element in rational decision making or represents a contrary "non-rational" element in accounting for human conduct. © 2010

The correlates of crime and deviance: Additional evidence

Comparable survey data collected simultaneously in major cities in Greece, Russia, and Ukraine indicate that the usual correlates of self-reported criminal/deviant behavior derived from research in well-studied, mostly Western societies, do not necessarily hold cross-nationally. The data confirm only two of six potential correlates of self-reported criminal/deviant behavior-age and deviant peer association. Two widely assumed correlates of criminal propensity-gender and marital status-prove to be somewhat unreliable and sensitive to these cultural contexts. Religiosity is generally negatively linked to crime/deviance in bivariate but not multivariate analyses. In bivariate analysis socioeconomic status (SES) proves to be highly sensitive to the investigated cultural contexts whereas in multivariate analysis SES is not significantly related in any consistent fashion to criminality in any of the three countries. These results show the value of cross-cultural research and suggest that effective explanation of criminal and deviant behavior may require more attention to cultural variations. © 2010 The Author(s)

The Effect of Captopril and Ascorbic Acid on Nonenzymatic Methionine Enkephalin Inactivation in the Guinea-Pig Ileum

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