Decomposition of a time series and forecasting on the example of PJSC Novolipetsk Metallurgical Combine shares

Currently, questions about the implementation of economic and production activities are raised quite often, namely about the dynamically changing market. The relevance of the topic lies in the importance and need to adhere to a number of methods when analyzing time series. The article presents arguments justifying the decomposition of the time series and forecasting. The authors analyze the Elliott Wave Theory method and give an interpretation of the price movement. They also describe a number of advantages of technical analysis. The article provides statistical data on the practical application of the Elliott Wave Theory at the largest steel-producing plant in Russia – PJSC Novolipetsk Metallurgical Combine. The researchers analyzed the trend of the shares of PJSC Novolipetsk Metallurgical Combine and identified their real value in order to confirm the effective operation of the wave analysis

Effects of neonatal handling on behavior and stress-response in rats selected for reaction towards humans

It is known that neonatal handling may cause longterm changes in neurobiological and behavioral phenotypes. Neonatal handling of rats selected for enhanced aggressiveness towards humans (“aggressive” rats of generation 44) significantly mitigated aggression and stress responsiveness. However, levels of corticosterone in stress in intact aggressive rats of later generations (70s) were lower than in generation 44, which differed little from the corresponding value in “tame” rats, selected in the opposite direction, for the absence of aggressiveness towards humans. The study was conducted with Norway rat populations of the 75th generation of selection for aggressive and tame behavior, respectively. The goal was to find out whether the decrease in stress response in aggressive rats at the current stage of selection was accompanied by a decrease in the influence of handling on aggressiveness. It was found that neonatal handling of aggressive animals caused a significant decrease in aggressiveness, although considerably smaller than in generation 44. In both aggressive and tame rats, the blood corticosterone level at stress was getting back to the basal level for a longer time than in the corresponding control groups. Neonatal handling decreased the amount of mRNA for the glucocorticoid receptor (GR) in the hippocampus of aggressive rats but did not affect significantly the amount of mRNA for the corticotropin-releasing hormone (CRH) in the hypothalamus. However, higher contents of CRH mRNA were recorded in aggressive rats than in tame ones in the control groups. However, no differences in glucocorticoid receptor mRNA  were found between the strains in contrast to earlier generations. It was shown that neonatal handling was beneficial for maternal behavior in tame rats. Thus, the results obtained in the 75th generation of selection indicate that the effect of handling on aggressiveness weakens with decreasing stress responsiveness in aggressive rats. This is likely to be related to the changing amount of GR in the hippocampus and stronger glucocorticoidmediated feedback at the current stage of selection. The minor prolongation of the stress response appears to be related to the stressing component of neonatal handling rather than to changes in maternal care