ANNz: estimating photometric redshifts using artificial neural networks

We introduce ANNz, a freely available software package for photometric redshift estimation using Artificial Neural Networks. ANNz learns the relation between photometry and redshift from an appropriate training set of galaxies for which the redshift is already known. Where a large and representative training set is available ANNz is a highly competitive tool when compared with traditional template-fitting methods. The ANNz package is demonstrated on the Sloan Digital Sky Survey Data Release 1, and for this particular data set the r.m.s. redshift error in the range 0 < z < 0.7 is 0.023. Non-ideal conditions (spectroscopic sets which are small, or which are brighter than the photometric set for which redshifts are required) are simulated and the impact on the photometric redshift accuracy assessed.Comment: 6 pages, 6 figures. Replaced to match version accepted by PASP (minor changes to original submission). The ANNz package may be obtained from http://www.ast.cam.ac.uk/~aa

Mechanisms of burst release from pH-responsive polymeric microparticles.

Microencapsulation of drugs into preformed polymers is commonly achieved through solvent evaporation techniques or spray drying. We compared these encapsulation methods in terms of controlled drug release properties of the prepared microparticles and investigated the underlying mechanisms responsible for the “burst release” effect. Using two different pH-responsive polymers with a dissolution threshold of pH 6 (Eudragit L100 and AQOAT AS-MG), hydrocortisone, a model hydrophobic drug, was incorporated into microparticles below and above its solubility within the polymer matrix. Although, spray drying is an attractive approach due to rapid particle production and relatively low solvent waste, the oil-in-oil microencapsulation method is superior in terms of controlled drug release properties from the microparticles. Slow solvent evaporation during the oil-in-oil emulsification process allows adequate time for drug and polymer redistribution in the microparticles and reduces uncontrolled drug burst release. Electron microscopy showed that this slower manufacturing procedure generated non-porous particles whereas thermal analysis and X-ray diffractometry showed that drug loading above the solubility limit of the drug in the polymer generated excess crystalline drug on the surface of the particles. Raman spectral mapping illustrated that drug was homogeneously distributed as a solid solution in the particles when loaded below saturation in the polymer with consequently minimal burst release

Quarkonium states in an anisotropic QCD plasma

We consider quarkonium in a hot QCD plasma which, due to expansion and non-zero viscosity, exhibits a local anisotropy in momentum space. At short distances the heavy-quark potential is known at tree level from the hard-thermal loop resummed gluon propagator in anisotropic perturbative QCD. The potential at long distances is modeled as a QCD string which is screened at the same scale as the Coulomb field. At asymptotic separation the potential energy is non-zero and inversely proportional to the temperature. We obtain numerical solutions of the three-dimensional Schroedinger equation for this potential. We find that quarkonium binding is stronger at non-vanishing viscosity and expansion rate, and that the anisotropy leads to polarization of the P-wave states.Comment: 18 pages, 6 figures, final version, to appear in PR

Boson mass spectrum in SU(4)L⊗U(1)YSU(4)_L\otimes U(1)_Y model with exotic electric charges

The boson mass spectrum of the electro-weak \textbf{$SU(4)_{L}\otimes U(1)_{Y}$} model with exotic electric charges is investigated by using the algebraical approach supplied by the method of exactly solving gauge models with high symmetries. Our approach predicts for the boson sector a one-parameter mass scale to be tuned in order to match the data obtained at LHC, LEP, CDF.Comment: 12 pages, 1 Table with numerical estimates and 1 Figure added, mistaken results correcte

Public ubiquitous computing systems:lessons from the e-campus display deployments

In this paper we reflect on our experiences of deploying ubiquitous computing systems in public spaces and present a series of lessons that we feel will be of benefit to researchers planning similar public deployments. We focus on experiences gained from building and deploying three experimental public display systems as part of the e-campus pro ject. However, we believe the lessons are likely to be generally applicable to many different types of public ubicomp deployment

Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray

The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in nociceptive processing in the vlPAG. It has been suggested that glutamatergic neurotransmission exerts antinociceptive effects, whereas GABAergic neurotransmission exert pronociceptive effects on pain transmission, through descending pathways. The inability to exclusively manipulate subpopulations of neurons in the PAG has prevented direct testing of this hypothesis. Here, we demonstrate the different contributions of genetically defined glutamatergic and GABAergic vlPAG neurons in nociceptive processing by employing cell type-specific chemogenetic approaches in mice. Global chemogenetic manipulation of vlPAG neuronal activity suggests that vlPAG neural circuits exert tonic suppression of nociception, consistent with previous pharmacological and electrophysiological studies. However, selective modulation of GABAergic or glutamatergic neurons demonstrates an inverse regulation of nociceptive behaviors by these cell populations. Selective chemogenetic activation of glutamatergic neurons, or inhibition of GABAergic neurons, in vlPAG suppresses nociception. In contrast, inhibition of glutamatergic neurons, or activation of GABAergic neurons, in vlPAG facilitates nociception. Our findings provide direct experimental support for a model in which excitatory and inhibitory neurons in the PAG bidirectionally modulate nociception

Local moments and symmetry breaking in metallic PrMnSbO

We report a combined experimental and theoretical investigation of the layered antimonide PrMnSbO which is isostructural to the parent phase of the iron pnictide superconductors. We find linear resistivity near room temperature and Fermi liquid-like T^{2} behaviour below 150 K. Neutron powder diffraction shows that unfrustrated C-type Mn magnetic order develops below \sim 230 K, followed by a spin-flop coupled to induced Pr order. At T \sim 35 K, we find a tetragonal to orthorhombic (T-O) transition. First principles calculations show that the large magnetic moments observed in this metallic compound are of local origin. Our results are thus inconsistent with either the itinerant or frustrated models proposed for symmetry breaking in the iron pnictides. We show that PrMnSbO is instead a rare example of a metal where structural distortions are driven by f-electron degrees of freedom