Modulation of endoglin expression in islets of langerhans by VEGF reveals a novel regulator of islet endothelial cell function

BACKGROUND: Endoglin/CD105 is an auxiliary receptor for transforming growth factor-β with established roles in vascular remodelling. It has recently been shown that heterozygous endoglin deficiency in mice decreases insulin secretion in an animal model of obesity, highlighting a potential role for endoglin in the regulation of islet function. We have previously identified two different populations of endoglin expressing cells in human and mouse islets which are: (i) endothelial cells (ECs) and (ii) islet mesenchymal stromal cells. The contribution of islet EC endoglin expression to islet development and sensitivity to VEGF is unknown and is the focus of this study. RESULTS: In vitro culture of mouse islets with VEGF164 for 48 h increased endoglin mRNA levels above untreated controls but VEGF did not modulate VEGFR2, CD31 or CD34 mRNA expression or islet viability. Removal of EC-endoglin expression in vivo reduced islet EC area but had no apparent effect on islet size or architecture. CONCLUSION: EC-specific endoglin expression in islets is sensitive to VEGF and plays partial roles in driving islet vascular development, however such regulation appears to be distinct to mechanisms required to modulate islet viability and size

Practical Implementations of Twirl Operations

Twirl operations, which convert impure singlet states into Werner states, play an important role in many schemes for entanglement purification. In this paper we describe strategies for implementing twirl operations, with an emphasis on methods suitable for ensemble quantum information processors such as nuclear magnetic resonance (NMR) quantum computers. We implement our twirl operation on a general two-spin mixed state using liquid state NMR techniques, demonstrating that we can obtain the singlet Werner state with high fidelity.Comment: 6 pages RevTex4 including 2 figures (fig 1 low quality to save space

Robust Ising Gates for Practical Quantum Computation

I describe the use of techniques based on composite rotations to combat systematic errors in controlled phase gates, which form the basis of two qubit quantum logic gates. Although developed and described within the context of Nuclear Magnetic Resonanace (NMR) quantum computing these sequences should be applicable to any implementation of quantum computation based on Ising couplings. In combination with existing single qubit gates this provides a universal set of robust quantum logic gates.Comment: 3 Pages RevTex4 including 2 figures. Will submit to PR

The M Dwarf GJ 436 and its Neptune-Mass Planet

We determine stellar parameters for the M dwarf GJ 436 that hosts a Neptune-mass planet. We employ primarily spectral modeling at low and high resolution, examining the agreement between model and observed optical spectra of five comparison stars of type, M0-M3. Modeling high resolution optical spectra suffers from uncertainties in TiO transitions, affecting the predicted strengths of both atomic and molecular lines in M dwarfs. The determination of Teff, gravity, and metallicity from optical spectra remains at ~10%. As molecules provide opacity both in lines and as an effective continuum, determing molecular transition parameters remains a challenge facing models such as the PHOENIX series, best verified with high resolution and spectrophotometric spectra. Our analysis of GJ 436 yields an effective temperature of Teff = 3350 +/- 300 K and a mass of 0.44 Msun. New Doppler measurements for GJ 436 with a precision of 3 m/s taken during 6 years improve the Keplerian model of the planet, giving a minimum mass, M sin i = 0.0713 Mjup = 22.6 Mearth, period, P = 2.6439 d, and e = 0.16 +/- 0.02. The noncircular orbit contrasts with the tidally circularized orbits of all close-in exoplanets, implying either ongoing pumping of eccentricity by a more distant companion, or a higher Q value for this low-mass planet. The velocities indeed reveal a long term trend, indicating a possible distant companion.Comment: 27 pages, 7 figures, accepted to PAS

Masses, Oxygen and Carbon abundances in CHEPS dwarf stars

Reproduced with permission from Astronomy & Astrophysics. © 2019 ESOContext. We report the results from the determination of stellar masses, carbon, and oxygen abundances in the atmospheres of 107 stars from the Calan-Hertfordshire Extrasolar Planet Search (CHEPS) programme. Our stars are drawn from a population with a significantly super-solar metallicity. At least 10 of these stars are known to host orbiting planets. Aims. In this work, we set out to understand the behaviour of carbon and oxygen abundance in stars with different spectral classes, metallicities, and V sin i within the metal-rich stellar population. Methods. Masses of these stars were determined using data from Gaia DR2. Oxygen and carbon abundances were determined by fitting the absorption lines. We determined oxygen abundances with fits to the 6300.304 Å O I line, and we used 3 lines of the C I atom and 12 lines of the C 2 molecule for the determination of carbon abundances. Results. We determine masses and abundances of 107 CHEPS stars. There is no evidence that the [C/O] ratio depends on V sin i or the mass of the star within our constrained range of masses, i.e. 0.82 5 km s -1) are massive stars.Peer reviewedFinal Published versio

Anomalous Thermal Stability of Metastable C_20 Fullerene

The results of computer simulation of the dynamics of fullerene C_20 at different temperatures are presented. It is shown that, although it is metastable, this isomer is very stable with respect to the transition to a lower energy configuration and retains its chemical structure under heating to very high temperatures, T ~ 3000 K. Its decay activation energy is found to be E_a ~ 7 eV. Possible decay channels are studied, and the height of the minimum potential barrier to decay is determined to be U = 5.0 eV. The results obtained make it possible to understand the reasons for the anomalous stability of fullerene C_20 under normal conditions.Comment: Slightly corrected version of the paper submitted to Phys. Solid Stat

Band Calculation for Ce-compounds on the basis of Dynamical Mean Field Theory

The band calculation scheme for $f$ electron compounds is developed on the basis of the dynamical mean field theory (DMFT) and the LMTO method. The auxiliary impurity problem is solved by a method named as NCA$f^{2}$v', which includes the correct exchange process of the $f^{1} \to f^{2}$ virtual excitation as the vertex correction to the non-crossing approximation (NCA) for the $f^{1} \to f^{0}$ fluctuation. This method leads to the correct magnitude of the Kondo temperature, $T_{\rm K}$, and makes it possible to carry out quantitative DMFT calculation including the crystalline field (CF) and the spin-orbit (SO) splitting of the self-energy. The magnetic excitation spectra are also calculated to estimate $T_{\rm K}$. It is applied to Ce metal and CeSb at T=300 K as the first step. In Ce metal, the hybridization intensity (HI) just below the Fermi energy is reduced in the DMFT band. The photo-emission spectra (PES) have a conspicuous SO side peak, similar to that of experiments. $T_{\rm K}$ is estimated to be about 70 K in $\gamma$-Ce, while to be about 1700 K in $\alpha$-Ce. In CeSb, the double-peak-like structure of PES is reproduced. In addition, $T_{\rm K}$ which is not so low is obtained because HI is enhanced just at the Fermi energy in the DMFT band.Comment: 30pages, 18 figure

Spin, Charge and Quasiparticle Gaps in the One-Dimensional Kondo Lattice with f^2 Configuration

The ground state properties of the one-dimensional Kondo lattice with an f^2 configuration at each site are studied by the density matrix renormalization group method. At half-filling, competition between the Kondo exchange J and the antiferromagnetic intra f-shell exchange I leads to reduction of energy gaps for spin, quasi-particle and charge excitations. The attractive force among conduction electrons is induced by the competition and the bound state is formed. As J/I increases the f^2 singlet gives way to the Kondo singlet as the dominant local correlation. The remarkable change of the quasi-particle gap is driven by the change of the spin-1/2 excitation character from the itinerant one to the localized one. Possible metal-insulator transition is discussed which may occur as the ratio J/I is varied by reference to mean-field results in the f^2 lattice system and the two impurity Kondo system.Comment: 7 pages, 7 figures, submitted to J. Phys. Soc. Jp