Assessing price sustainability in the Irish housing market: a county-level analysis. ESRI Research Notes 2019/4/1

In the wake of a number of high profile property crashes, a question that has come to the fore recently is; are housing booms and busts clustered in specific areas within countries or do they tend to be more pan-regional? Within the United States for example, considerable variation in the boom-bust cycle has been experienced with the so-called ‘sand states’ (California, Florida, Arizona, and Nevada) showing much greater fluctuations in prices than other regions following the financial crisis.2 In an Irish context, a significant issue of interest is the apparent divergence between the Dublin property market and other regional markets as well as the difference between urban and rural areas

A county-level perspective on housing affordability in Ireland. ESRI Research Notes 2019/4/2

The issue of housing affordability in Ireland has come to the fore in recent years as house prices have increased significantly following the recovery. In a recent survey, Corrigan et al. (2019a) find that 86.5 per cent of renters expressed a preference for homeownership. However, rising house prices have led to serious concerns about the ability of first time buyers (FTB) to enter the housing market. This group has been cited as one particular pressure point in recent assessments of market affordability (Housing Agency, 2017). Analysis published in the ESRI Quarterly Economic Commentary (McQuinn et al., 2018) finds that house price growth has been uneven across the distribution, with cheaper properties growing at faster rates than more expensive properties. This is likely to further exacerbate the affordability concerns of first time buyers, who typically enter the housing market at lower house price levels than second and subsequent borrowers

Quarterly Economic Commentary, Autumn 2019.

Although the Irish economy continues to perform in a robust manner, a number of considerations arise given the present growth performance. Firstly, due to certain multinational related activities, a divergence is likely once again between headline and underlying output growth for the present year. While we are revising upwards our forecast of headline GDP to just less than 5 per cent for 2019, certain underlying data would suggest the growth outlook has moderated somewhat as we move through the present year. Secondly, a number of significant international related risks are on the horizon for the Irish economy. As with previous Commentaries, our forecasts, unless otherwise stated, are subject to the technical assumption that the United Kingdom remains part of the European Union

Measurement of Subcellular Force Generation in Neurons

AbstractForces are important for neuronal outgrowth during the initial wiring of the nervous system and after trauma, yet subcellular force generation over the microtubule-rich region at the rear of the growth cone and along the axon has never, to our knowledge, been directly measured. Because previous studies have indicated microtubule polymerization and the microtubule-associated proteins Kinesin-1 and dynein all generate forces that push microtubules forward, a major question is whether the net forces in these regions are contractile or expansive. A challenge in addressing this is that measuring local subcellular force generation is difficult. Here we develop an analytical mathematical model that describes the relationship between unequal subcellular forces arranged in series within the neuron and the net overall tension measured externally. Using force-calibrated towing needles to measure and apply forces, in combination with docked mitochondria to monitor subcellular strain, we then directly measure force generation over the rear of the growth cone and along the axon of chick sensory neurons. We find the rear of the growth cone generates 2.0 nN of contractile force, the axon generates 0.6 nN of contractile force, and that the net overall tension generated by the neuron is 1.3 nN. This work suggests that the forward bulk flow of the cytoskeletal framework that occurs during axonal elongation and growth-cone pauses arises because strong contractile forces in the rear of the growth cone pull material forward

Quarterly Economic Commentary, Winter 2018.

The Irish economy looks set to register another very strong year of growth in 2018, with the outlook remaining positive as well for 2019. While difficulties persist with the interpretation of the National Accounts, it is fair to say that the growth performance in 2018 has been broadly based with both domestic and external factors contributing significantly to the growth performance

Quarterly Economic Commentary, Spring 2019.

2018 saw the Irish economy register another sizeable increase in activity with GDP estimated to have risen by 6.7 per cent. While some of this increase is due to the disproportionate activities of a select number of multinational firms, the underlying performance of the economy is still remarkably strong. Increases in taxation receipts, even aside from corporation taxes and the ongoing dynamic performance of the labour market, are compelling evidence of this

Quarterly Economic Commentary, Summer 2019.

While a number of international concerns continue to cast a shadow on the domestic economy, both taxation receipts and labour market indicators suggest that the Irish economy continues to perform strongly in 2019. Output is still forecast to grow by 4.0 per cent in 2019 before moderating somewhat at 3.2 per cent in 2020. Unemployment is set to fall to 4.5 per cent by the end of the present year and to 4.1 per cent at the end of the next year. All forecasts, unless otherwise stated, maintain the Commentary’s baseline assumption that the trading status of the United Kingdom remains equivalent to that of a full European Union Member State

A Hierarchical Cascade of Second Messengers Regulates Pseudomonas aeruginosa Surface Behaviors

Biofilms are surface-attached multicellular communities. Using single-cell tracking microscopy, we showed that apilY1 mutant of Pseudomonas aeruginosa is defective in early biofilm formation. We leveraged the observation that PilY1 pro- tein levels increase on a surface to perform a genetic screen to identify mutants altered in surface-grown expression of this pro- tein. Based on our genetic studies, we found that soon after initiating surface growth, cyclic AMP (cAMP) levels increase, depen- dent on PilJ, a chemoreceptor-like protein of the Pil-Chp complex, and the type IV pilus (TFP). cAMP and its receptor protein Vfr, together with the FimS-AlgR two-component system (TCS), upregulate the expression of PilY1 upon surface growth. FimS and PilJ interact, suggesting a mechanism by which Pil-Chp can regulate FimS function. The subsequent secretion of PilY1 is dependent on the TFP assembly system; thus, PilY1 is not deployed until the pilus is assembled, allowing an ordered signaling cascade. Cell surface-associated PilY1 in turn signals through the TFP alignment complex PilMNOP and the diguanylate cyclase SadC to activate downstream cyclic di-GMP (c-di-GMP) production, thereby repressing swarming motility. Overall, our data support a model whereby P. aeruginosa senses the surface through the Pil-Chp chemotaxis-like complex, TFP, and PilY1 to reg- ulate cAMP and c-di-GMP production, thereby employing a hierarchical regulatory cascade of second messengers to coordinate its program of surface behaviors

Emergence and spread of a SARS-CoV-2 lineage A variant (A.23.1) with altered spike protein in Uganda

Here, we report SARS-CoV-2 genomic surveillance from March 2020 until January 2021 in Uganda, a landlocked East African country with a population of approximately 40 million people. We report 322 full SARS-CoV-2 genomes from 39,424 reported SARS-CoV-2 infections, thus representing 0.8% of the reported cases. Phylogenetic analyses of these sequences revealed the emergence of lineage A.23.1 from lineage A.23. Lineage A.23.1 represented 88% of the genomes observed in December 2020, then 100% of the genomes observed in January 2021. The A.23.1 lineage was also reported in 26 other countries. Although the precise changes in A.23.1 differ from those reported in the first three SARS-CoV-2 variants of concern (VOCs), the A.23.1 spike-protein-coding region has changes similar to VOCs including a change at position 613, a change in the furin cleavage site that extends the basic amino acid motif and multiple changes in the immunogenic N-terminal domain. In addition, the A.23.1 lineage has changes in non-spike proteins including nsp6, ORF8 and ORF9 that are also altered in other VOCs. The clinical impact of the A.23.1 variant is not yet clear and it has not been designated as a VOC. However, our findings of emergence and spread of this variant indicate that careful monitoring of this variant, together with assessment of the consequences of the spike protein changes for COVID-19 vaccine performance, are advisable