Radiological remission and recovery of thirst appreciation after infliximab therapy in adipsic diabetes insipidus secondary to neurosarcoidosis

Background: Neurosarcoidosis is a rare and aggressive variant of systemic sarcoidosis which may result in hypothalamic-pituitary dysfunction. We report a case of hypothalamic hypopituitarism secondary to neurosarcoidosis complicated by adipsic diabetes insipidus (ADI). Initiation of anti-tumour necrosis factor-alpha (TNF-alpha) therapy resulted in both radiological disease remission and recovery of osmoregulated thirst appreciation after 3 months. Case summary: A 22-year-old man was referred to the endocrinology service with profound weight gain, polyuria and lethargy. Biochemical testing confirmed anterior hypopituitarism while posterior pituitary failure was confirmed by hypotonic polyuria responding to desmopressin. Magnetic resonance imaging (MRI) demonstrated extensive hypothalamic infiltration; neurosarcoidosis was confirmed histologically after excisional cervical lymph node biopsy. Osmoregulated thirst appreciation was normal early in the disease course despite severe hypotonic polyuria. However, subsequent subjective loss of thirst appreciation and development of severe hypernatraemia in the setting of normal cognitive function indicated onset of ADI. Management: Clinical management involved daily weighing, regular plasma sodium measurement, fixed daily fluid intake and oral desmopressin. We initiated immunosuppressive therapy with pulsed intravenous anti-TNF-alpha therapy (infliximab) after multidisciplinary team consultation. Outcome: Infliximab therapy resulted in successful radiological disease remission and complete recovery of osmoregulated thirst appreciation. This was confirmed by subjective return of thirst response and maintenance of plasma sodium in the normal range in the absence of close biochemical monitoring

The influence of parafoveal word length and contextual constraint on fixation durations and word skipping in reading

The present study examined the relationship between the predictability of words within a sentence and the availability of parafoveal word length information, on when and where the eyes move in reading. Predictability influenced first-pass reading times when parafoveal word length preview information was correct, but not when it was incorrect. Similarly, for saccades launched from near the target word (word n), predictability influenced the probability with which it was skipped only when the word length preview was correct. By contrast, for saccades launched farther away from word n, predictability influenced word skipping regardless of the parafoveal word length preview. Taken together, the data suggest that parafoveal word length preview and predictability can act as a joint constraint on the decision of when and where to move the eyes