Per-operative stent placement in the right pulmonary artery; a hybrid technique for the management of pulmonary artery branch stenosis at the time of pulmonary valve replacement in adult Fallot patients

After having undergone surgical correction at an early age, many patients with tetralogy of Fallot develop long-term complications including progressive pulmonary regurgitation and peripheral pulmonary stenosis. A high percentage of these patients need to undergo a second operation in their adolescence or early adulthood. If simultaneous treatment of both pulmonary regurgitation and peripheral pulmonary stenosis is warranted, a complete surgical approach has several disadvantages. We describe four cases of Fallot patients with severe pulmonary regurgitation and peripheral pulmonary stenosis who were treated using a hybrid approach involving surgical implantation of a pulmonary homograft and peroperative stenting of the pulmonary artery

Characterising food insecurity in pastoral and agro-pastoral communities in Uganda using a consumption coping strategy index

We explore the utility of a consumption coping strategy index (CSI) in characterising and assessing the factors influencing household food insecurity. We assessed 53 pastoral and 197 agro-pastoral households in Nakasongola and Nakaseke districts of Uganda, examining the use of 27 consumption coping strategies over a recall time of two 30-day periods, one at the start of a dry season in 2012 and one at the start of a rainy season in 2013. Four categorical food insecurity status measures were established - food secure (CSI 0 to 5) and mildly (CSI 6 to 20), moderately (CSI 21 to 42) and extremely (CSI >42) food insecure. For the dry season, the mean CSI was 29.4 ± 2.59 and 33.6 % of households were food secure, while for the rains, mean CSI was 33.1 ± 2.30 and 14.0 % of households were food secure. The combination of livelihood system, land holdings, number of livestock owned and belonging to a social network explained 9.4 % to 10 % of the variance in household food insecurity for agro-pastoralists, but variance for pastoralists was not explained by these factors. While the only highly significant factor associated with increasing household food insecurity in the dry season was low landholdings, in the rainy season, it was pastoral livelihood, low livestock holdings for agro-pastoralists and non-involvement in social networks. While our model identified a number of factors important in describing household food insecurity, it explained only about 10 % of the variance

Diet diversity in pastoral and agro-pastoral households in Ugandan rangeland ecosystems

We explore how diet diversity differs with agricultural seasons and between households within pastoral and agro-pastoral livelihood systems, using variety of foods consumed as a less complex proxy indicator of food insecurity than benchmark indicators like anthropometry and serum nutrients. The study was in the central part of the rangelands in Uganda. Seventy nine households were monitored for three seasons, and eight food groups consumed during a 24 hour diet recall period used to create a household diet diversity score (HDDS). Mean HDDS was 3.2, varied significantly with gender, age, livelihood system and season (p < .001, F = 15.04), but not with household size or household head’s education level. Agro-pastoralists exhibited lower mean diet diversity than pastoralists (p < .01, F = 7.84) and among agro-pastoralists, households headed by persons over 65 years were most vulnerable (mean HDDS 2.1). This exploratory study raises issues requiring further investigation to inform policies on nutrition security in the two communities

How Treatment Partners Help: Social Analysis of an African Adherence Support Intervention

Treatment partnering is an adherence intervention developed in sub-Saharan Africa. This paper describes the additional social functions that treatment partners serve and shows how these functions contribute to health and survival for patients with HIV/AIDS. Ninety-eight minimally structured interviews were conducted with twenty pairs of adult HIV/AIDS patients (N = 20) and treatment partners (N = 20) treated at a public HIV-care setting in Tanzania. Four social functions were identified using inductive, category construction and interpretive methods of analysis: (1) encouraging disclosure; (2) combating stigma; (3) restoring hope; and (4) reducing social difference. These functions work to restore social connections and reverse the isolating effects of HIV/AIDS, strengthening access to essential community safety nets. Besides encouraging ARV adherence, treatment partners contribute to the social health of patients. Social health as well as HIV treatment success is essential to survival for persons living with HIV/AIDS in sub-Saharan Africa

“Reproducing the social”: Contradictory interconnections between land, cattle production and household relations in the Besters Land Reform Project, South Africa

Land redistribution policy in South Africa emphasises commercial farming as the legitimate use of land. This production-oriented framework fails to take into account the intertwined but unstable relationship between the production of market value and social reproduction, and how this shapes social differentiation. Drawing on a case study of the Besters Land Reform Project in the province of KwaZulu-Natal, the paper shows that land and cattle are not simply moments in the production of beef but material and discursive resources in (re)making the social conditions of the household. Cattle are used in drawn-out ceremonies that occur in specific spaces and stitch together families and communities pulled apart by rising inequality, making land constitutive of identity and belonging as well as of capitalist value production. Until land reform policy recognises the multi-functionality of land and cattle, and the contradictory relationship between functions, agricultural production will be a limited indicator of “success” or “failure.

Integrated genomic characterization of endometrial carcinoma

SummaryWe performed an integrated genomic, transcriptomic, and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumors and ~25% of high-grade endometrioid tumors have extensive copy number alterations, few DNA methylation changes, low ER/PR levels, and frequent TP53 mutations. Most endometrioid tumors have few copy number alterations or TP53 mutations but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A, KRAS and novel mutations in the SWI/SNF gene ARID5B. A subset of endometrioid tumors we identified had a dramatically increased transversion mutation frequency, and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy number low, and copy number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may impact post-surgical adjuvant treatment for women with aggressive tumors

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

A framework for human microbiome research

A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resulting in a broad range of quality-controlled resources and data including standardized methods for creating, processing and interpreting distinct types of high-throughput metagenomic data available to the scientific community. Here we present resources from a population of 242 healthy adults sampled at 15 or 18 body sites up to three times, which have generated 5,177 microbial taxonomic profiles from 16S ribosomal RNA genes and over 3.5 terabases of metagenomic sequence so far. In parallel, approximately 800 reference strains isolated from the human body have been sequenced. Collectively, these data represent the largest resource describing the abundance and variety of the human microbiome, while providing a framework for current and future studies