Factors that support or inhibit academic affairs and student affairs from working collaboratively to better support holistic students’ experiences: a phenomenological study

Within a traditional organizational structure in higher education, academic and student affairs divisions may not be collaborating well, and the lack of such collaboration may be impacting the students' holistic experiences. Students’ academic and personal development depends not only on the quality of the curriculum and classroom instruction, but also on the quality of another major educational division within the university, student development services, departments commonly collected under the umbrella known as student affairs. This qualitative phenomenological study seeks to identify the factors supporting or inhibiting academic affairs faculty and student affairs professionals from working collaboratively to better support students' holistic experiences. Using three primary methods of data collection – interviews, focus groups, and document review – the researcher examined the following questions: 1) How do higher education professionals describe the interaction between the silos of academic affairs and student affairs divisions? 2) From inhibiting to supporting, what is the spectrum of factors that impact how academic affairs faculty and student affairs professionals work collaboratively? and 3) What are the elements of collaboration between academic and student affairs divisions that would benefit student development? The research intended to examine the collaborative climate on the UC Davis campus in regard to the working relationships between student affairs professionals and academic affair faculty. Five emergent themes ascended from the research: (1) Academic Success, (2) Need for Collaboration and Relationship Building, (3) Silos, (4) Lack of Knowledge of the Other Divisions, and (5) Student Experience. As a result, the research found many factors supporting and inhibiting collaborative work between Academic Affairs and Student Affairs professionals. It is evident silos exist, causing a disconnect in communication, resources, student support, and collaboration between the two divisions. Leadership, increased collaboration, and sharing of information will assist in the deconstruction of preexisting silos. The Academic and Student Affairs Divisions leadership needs to fulfill the mission, goals, and values of their division, while always putting the student first. To accomplish this, the leadership must focus on the mission of the university, reach across silos, and focus on holistic collaborative partnerships that shape the holistic students’ experiences.Ed.D., Educational Leadership and Management -- Drexel University, 201

Factors that support or inhibit academic affairs and student affairs from working collaboratively to better support holistic students’ experiences: a phenomenological study

Within a traditional organizational structure in higher education, academic and student affairs divisions may not be collaborating well, and the lack of such collaboration may be impacting the students' holistic experiences. Students’ academic and personal development depends not only on the quality of the curriculum and classroom instruction, but also on the quality of another major educational division within the university, student development services, departments commonly collected under the umbrella known as student affairs. This qualitative phenomenological study seeks to identify the factors supporting or inhibiting academic affairs faculty and student affairs professionals from working collaboratively to better support students' holistic experiences. Using three primary methods of data collection – interviews, focus groups, and document review – the researcher examined the following questions: 1) How do higher education professionals describe the interaction between the silos of academic affairs and student affairs divisions? 2) From inhibiting to supporting, what is the spectrum of factors that impact how academic affairs faculty and student affairs professionals work collaboratively? and 3) What are the elements of collaboration between academic and student affairs divisions that would benefit student development? The research intended to examine the collaborative climate on the UC Davis campus in regard to the working relationships between student affairs professionals and academic affair faculty. Five emergent themes ascended from the research: (1) Academic Success, (2) Need for Collaboration and Relationship Building, (3) Silos, (4) Lack of Knowledge of the Other Divisions, and (5) Student Experience. As a result, the research found many factors supporting and inhibiting collaborative work between Academic Affairs and Student Affairs professionals. It is evident silos exist, causing a disconnect in communication, resources, student support, and collaboration between the two divisions. Leadership, increased collaboration, and sharing of information will assist in the deconstruction of preexisting silos. The Academic and Student Affairs Divisions leadership needs to fulfill the mission, goals, and values of their division, while always putting the student first. To accomplish this, the leadership must focus on the mission of the university, reach across silos, and focus on holistic collaborative partnerships that shape the holistic students’ experiences.Ed.D., Educational Leadership and Management -- Drexel University, 201

Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo

Meeting Abstracts: Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo Clearwater Beach, FL, USA. 9-11 June 201

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Sex differences in oncogenic mutational processes

Funder: Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology); doi: https://doi.org/10.13039/501100002790Funder: Genome Canada (Génome Canada); doi: https://doi.org/10.13039/100008762Funder: Canada Foundation for Innovation (Fondation canadienne pour l'innovation); doi: https://doi.org/10.13039/501100000196Funder: Terry Fox Research Institute (Institut de Recherche Terry Fox); doi: https://doi.org/10.13039/501100004376Abstract: Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research