The use of three-dimensional conjugate CFD to enhance understanding of, and to verify, multi-modal heat transfer in dynamic laboratory test walls

This work describes the use of conjugate computational fluid dynamics (C-CFD) to simulate controlled laboratory based dynamic heat transfer tests on building components. This study proposes that conjugate CFD simulation can be used to evaluate the influence of combined convective and conductive heat transfer in multi-state building components. To this end, a solid wall and cavity wall were tested with a Calibrated Hotbox and subject to variable temperature conditions leading to combined convective and conductive heat transfer. The varying temperature of the heat source was monitored and used as the input boundary condition in the simulation model, which included a computational domain which encompassed the hot-side air chamber and the wall, including cavity when applicable. It was found acceptable accuracy could be realized with a simplified constant surface heat transfer coefficient with fixed air temperature on the cold air side, which greatly reduced computational effort. The experimental results revealed that the cavity wall experienced a phase lag, peak displacement of 2.9 times higher and decrement factor 1.6 times lower compared with that of the solid wall

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead