Development and Demonstration of a Field-Deployable fast Chromotomographic Imager

A field deployable hyperspectral imager utilizing chromotomography (CT), with a direct vision prism (DVP) as the dispersive element, has been constructed at AFIT. This research is focused on the development and demonstration of the CT imager. An overview of hyperspectral imaging, chromotomography, a synopsis of reconstruction algorithms, and other CT instruments are given. The importance of component alignment, instrument calibration, and exact prism angular position data are discussed. A simplistic \shift and add reconstruction algorithm was utilized for this research. Although limited in its ability to reconstruct a spatially and spectrally diverse scene, the algorithm was adequate for the testing and characterization of the CT imager. The AFIT instrument is currently the fastest known DVP based hyperspectral CT imager and is a prototype for a planned space-based system. The instrument has the ability to capture spatial and spectral data of static and transient scenes. Spectral and spatial reconstructions of static scenes are presented in the Experimental Results and Analysis section of this paper. These reconstruction illustrate the effectiveness of the instrument to collect spatial and spectral data. More importantly, the imager can capture spectral data of rapidly evolving scenes such as explosions. The spectrum of a transient event, a firecracker explosion, lasting approximately 0.12 s is presented. Spectral results of the explosion show potassium and sodium emission lines present during the explosion and an absorption feature as the fireball extinguishes. Spatial and spectral reconstruction of a scene in which an explosion occurs during the middle of the collection period is also presented in the Experimental Results and Analysis section of this paper

The Spatial Distribution and Origins of Sandstone Monoliths in the Swauk Watershed, Kittitas County, WA

Large groups of gigantic sandstone and conglomerate monoliths populate the Swauk Watershed of northern Kittitas County. These monoliths rest on side slopes in the watershed and distinctively project from their surroundings. The origins of these features are unknown. We studied these monoliths in the field by mapping their spatial distribution, describing their morphology and composition, and measuring their orientation and sizes in order to determine their origins. We used Google Earth and topographic maps to locate the monoliths and map their distribution. Interpretations were based from field work data and past research. Our field results show commonalities between the features related to overall structure, composition, and geomorphology. All monoliths studied were associated with dipping strata. Dip slopes are gently sloping while anti-dip slopes are much steeper. The monoliths also have distinct and traceable conglomerate layers that are highly resistant to erosion, as well as thick sandstone layers and some smaller pebble layers. These features also share similar geomorphology: they are surrounded by channels; fresh surfaces are lichen-free; honeycomb weathering and overhangs dominate the anti-dip slopes; and prominent vertically aligned jointing parallels the dipping beds. These results indicate that geologic composition and structure play a significant role in the initial shaping of these landforms. Differential weathering, fluvial erosion, and mass movement weakened the sandstone to cause low bedrock escarpments to retreat on the slopes, which carved out vertically aligned joints. The repetitive cycle of weathering, mass movement, and stream erosion has ultimately been the cause of the isolation of the sandstone monoliths over time

Dual Enrollment between High Schools and a Metropolitan University

Concurrent/dual enrollment programs at postsecondary educational institutions have rapidly proliferated across the country during the last several years with wide variations in the structure and composition of such programs. Having recently completed a pilot phase of its first dual enrollment program, the University of Nebraska at Omaha (UNO) has enjoyed great success due to a relatively unique partnership formed between the university and Omaha area school districts

The Transformation Project: 2014 Annual Report

For years debate has rumbled in this country over prison overcrowding. More recently, there has been an additional spotlight on issues that are exacerbated when prisons are over capacity, such as prison rape and the use of restrictive housing (housing inmates in isolated conditions). In the case of prison rape, federal standards have been placed on institutions through the passage of the Prison Rape Elimination Act (PREA). General consensus among corrections professionals is that a lack of internal action diminished their voice during the creation of the PREA standards. There is consequently a large motivation for correctional institutions to work to address concerns regarding restrictive housing. Groups like Amnesty International, the American Civil Liberties Union and the Association of State Correctional Administrators have all been contributing to this effort by each creating their own guidelines for using restrictive housing. 2014 was a great opportunity for us to reflect on how Transformation Project (TP) will benefit institutions as they look to revise how they house inmates that are a threat to themselves or others. Not only does TP provide programming for restrictive housing, where there has historically been a dearth of programming, it works to increase the amount and quality of interaction between staff and participants, as well as provide a measure for assessing progress in restrictive housing. All of these efforts are included in the recommendations across invested organizations, adding additional value to TP curriculum. In addition to strengthening TP in restrictive housing, this year we began exploring ways the program can be modified for use in a women’s facility. While there is much work to be done in this area, we are excited to bring adaptions to the curriculum that will specifically address the needs of justice involved women. We look forward to continuing the development process with our partners at the Nebraska Correctional Center for Women in York, Nebraska, as this group has been instrumental to providing essential expertise and feedback. As debates around corrections issues roll on, in the coming months we look forward to solidifying TP’s role in the rehabilitation of inmates throughout the course of their incarceration

Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging.

Methotrexate (MTX) is an immunosuppressant commonly used for the treatment of autoimmune diseases. Recent observations have shown that patients treated with MTX also exhibit a reduced risk for the development of cardiovascular disease (CVD). Although MTX reduces systemic inflammation and tissue damage, the mechanisms by which MTX exerts these beneficial effects are not entirely known. We have previously demonstrated that protein adducts formed by the interaction of malondialdehyde (MDA) and acetaldehyde (AA), known as MAA-protein adducts, are present in diseased tissues of individuals with rheumatoid arthritis (RA) or CVD. In previously reported studies, MAA-adducts were shown to be highly immunogenic, supporting the concept that MAA-adducts not only serve as markers of oxidative stress but may have a direct role in the pathogenesis of inflammatory diseases. Because MAA-adducts are commonly detected in diseased tissues and are proposed to mitigate disease progression in both RA and CVD, we tested the hypothesis that MTX inhibits the generation of MAA-protein adducts by scavenging reactive oxygen species. Using a cell free system, we found that MTX reduces MAA-adduct formation by approximately 6-fold, and scavenges free radicals produced during MAA-adduct formation. Further investigation revealed that MTX directly scavenges superoxide, but not hydrogen peroxide. Additionally, using the Nrf2/ARE luciferase reporter cell line, which responds to intracellular redox changes, we observed that MTX inhibits the activation of Nrf2 in cells treated with MDA and AA. These studies define previously unrecognized mechanisms by which MTX can reduce inflammation and subsequent tissue damage, namely, scavenging free radicals, reducing oxidative stress, and inhibiting MAA-adduct formation

Novel Antioxidant Properties of Doxycycline

Doxycycline (DOX), a derivative of tetracycline, is a broad-spectrum antibiotic that exhibits a number of therapeutic activities in addition to its antibacterial properties. For example, DOX has been used in the management of a number of diseases characterized by chronic inflammation. One potential mechanism by which DOX inhibits the progression of these diseases is by reducing oxidative stress, thereby inhibiting subsequent lipid peroxidation and inflammatory responses. Herein, we tested the hypothesis that DOX directly scavenges reactive oxygen species (ROS) and inhibits the formation of redox-mediated malondialdehyde-acetaldehyde (MAA) protein adducts. Using a cell-free system, we demonstrated that DOX scavenged reactive oxygen species (ROS) produced during the formation of MAA-adducts and inhibits the formation of MAA-protein adducts. To determine whether DOX scavenges specific ROS, we examined the ability of DOX to directly scavenge superoxide and hydrogen peroxide. Using electron paramagnetic resonance (EPR) spectroscopy, we found that DOX directly scavenged superoxide, but not hydrogen peroxide. Additionally, we found that DOX inhibits MAA-induced activation of Nrf2, a redox-sensitive transcription factor. Together, these findings demonstrate the under-recognized direct antioxidant property of DOX that may help to explain its therapeutic potential in the treatment of conditions characterized by chronic inflammation and increased oxidative stress

Mechanical design of the optical modules intended for IceCube-Gen2

IceCube-Gen2 is an expansion of the IceCube neutrino observatory at the South Pole that aims to increase the sensitivity to high-energy neutrinos by an order of magnitude. To this end, about 10,000 new optical modules will be installed, instrumenting a fiducial volume of about 8 km3. Two newly developed optical module types increase IceCube’s current sensitivity per module by a factor of three by integrating 16 and 18 newly developed four-inch PMTs in specially designed 12.5-inch diameter pressure vessels. Both designs use conical silicone gel pads to optically couple the PMTs to the pressure vessel to increase photon collection efficiency. The outside portion of gel pads are pre-cast onto each PMT prior to integration, while the interiors are filled and cast after the PMT assemblies are installed in the pressure vessel via a pushing mechanism. This paper presents both the mechanical design, as well as the performance of prototype modules at high pressure (70 MPa) and low temperature (−40∘C), characteristic of the environment inside the South Pole ice

The next generation neutrino telescope: IceCube-Gen2

The IceCube Neutrino Observatory, a cubic-kilometer-scale neutrino detector at the geographic South Pole, has reached a number of milestones in the field of neutrino astrophysics: the discovery of a high-energy astrophysical neutrino flux, the temporal and directional correlation of neutrinos with a flaring blazar, and a steady emission of neutrinos from the direction of an active galaxy of a Seyfert II type and the Milky Way. The next generation neutrino telescope, IceCube-Gen2, currently under development, will consist of three essential components: an array of about 10,000 optical sensors, embedded within approximately 8 cubic kilometers of ice, for detecting neutrinos with energies of TeV and above, with a sensitivity five times greater than that of IceCube; a surface array with scintillation panels and radio antennas targeting air showers; and buried radio antennas distributed over an area of more than 400 square kilometers to significantly enhance the sensitivity of detecting neutrino sources beyond EeV. This contribution describes the design and status of IceCube-Gen2 and discusses the expected sensitivity from the simulations of the optical, surface, and radio components

Sensitivity of IceCube-Gen2 to measure flavor composition of Astrophysical neutrinos

The observation of an astrophysical neutrino flux in IceCube and its detection capability to separate between the different neutrino flavors has led IceCube to constraint the flavor content of this flux. IceCube-Gen2 is the planned extension of the current IceCube detector, which will be about 8 times larger than the current instrumented volume. In this work, we study the sensitivity of IceCube-Gen2 to the astrophysical neutrino flavor composition and investigate its tau neutrino identification capabilities. We apply the IceCube analysis on a simulated IceCube-Gen2 dataset that mimics the High Energy Starting Event (HESE) classification. Reconstructions are performed using sensors that have 3 times higher quantum efficiency and isotropic angular acceptance compared to the current IceCube optical modules. We present the projected sensitivity for 10 years of data on constraining the flavor ratio of the astrophysical neutrino flux at Earth by IceCube-Gen2

Deep Learning Based Event Reconstruction for the IceCube-Gen2 Radio Detector

The planned in-ice radio array of IceCube-Gen2 at the South Pole will provide unprecedented sensitivity to ultra-high-energy (UHE) neutrinos in the EeV range. The ability of the detector to measure the neutrino’s energy and direction is of crucial importance. This contribution presents an end-to-end reconstruction of both of these quantities for both detector components of the hybrid radio array (\u27shallow\u27 and \u27deep\u27) using deep neural networks (DNNs). We are able to predict the neutrino\u27s direction and energy precisely for all event topologies, including the electron neutrino charged-current (νe-CC) interactions, which are more complex due to the LPM effect. This highlights the advantages of DNNs for modeling the complex correlations in radio detector data, thereby enabling a measurement of the neutrino energy and direction. We discuss how we can use normalizing flows to predict the PDF for each individual event which allows modeling the complex non-Gaussian uncertainty contours of the reconstructed neutrino direction. Finally, we discuss how this work can be used to further optimize the detector layout to improve its reconstruction performance