958 research outputs found
The Kast Ground Based UV Spectral Survey of 79 QSOs at Redshift 2 for Lyman Alpha Forest and Metal Absorption
We present a moderate resolution (~1.15 Angstroms/pixel) survey of 79 quasars
obtained using the Kast spectrograph on the Shane 3m telescope at Lick
observatory. The spectra span the wavelength range of 3175-5880 Angstroms, and
have typical signal to noise of 6-20 in the regions of the spectra showing
Lyman alpha forest absorption. The quasars have a mean emission redshift of
z=2.17, and nearly all cover the entire Lyman alpha forest between Lyman alpha
and Lyman beta. Although the quasars were selected to avoid BAL, two quasars in
the survey are BAL, one of which is a new discovery. We list the HI and metal
ions observed in a total of 140 absorption systems. We also identify 526
emission lines, and list their observed wavelengths, along with new redshifts
of the quasars. We determine the rest wavelengths of 3 emission lines or line
blends in the forest to be 1070.95 +/- 1.00, 1123.13 +/- 0.51, and 1175.88 +/-
0.30 Angstroms.Comment: Submitted to the Astronomical Journa
Derivation of Enriched Oligodendrocyte Cultures and Oligodendrocyte/Neuron Myelinating Co-cultures from Post-natal Murine Tissues
Identifying the molecular mechanisms underlying OL development is not only critical to furthering our knowledge of OL biology, but also has implications for understanding the pathogenesis of demyelinating diseases such as Multiple Sclerosis (MS). Cellular development is commonly studied with primary cell culture models. Primary cell culture facilitates the evaluation of a given cell type by providing a controlled environment, free of the extraneous variables that are present in vivo. While OL cultures derived from rats have provided a vast amount of insight into OL biology, similar efforts at establishing OL cultures from mice has been met with major obstacles. Developing methods to culture murine primary OLs is imperative in order to take advantage of the available transgenic mouse lines
Improvement of stabilizer based entanglement distillation protocols by encoding operators
This paper presents a method for enumerating all encoding operators in the
Clifford group for a given stabilizer. Furthermore, we classify encoding
operators into the equivalence classes such that EDPs (Entanglement
Distillation Protocol) constructed from encoding operators in the same
equivalence class have the same performance. By this classification, for a
given parameter, the number of candidates for good EDPs is significantly
reduced. As a result, we find the best EDP among EDPs constructed from [[4,2]]
stabilizer codes. This EDP has a better performance than previously known EDPs
over wide range of fidelity.Comment: 22 pages, 2 figures, In version 2, we enumerate all encoding
operators in the Clifford group, and fix the wrong classification of encoding
operators in version
Andromeda's Parachute: A Bright Quadruply Lensed Quasar at z=2.377
We present Keck Cosmic Web Imager spectroscopy of the four putative images of
the lensed quasar candidate J014709+463037 recently discovered by Berghea et
al. (2017). The data verify the source as a quadruply lensed, broad
absorption-line quasar having z_S = 2.377 +/- 0.007. We detect intervening
absorption in the FeII 2586, 2600, MgII 2796, 2803, and/or CIV 1548, 1550
transitions in eight foreground systems, three of which have redshifts
consistent with the photometric-redshift estimate reported for the lensing
galaxy (z_L ~ 0.57). By virtue of their positions on the sky, the source images
probe these absorbers over transverse physical scales of ~0.3-21 kpc,
permitting assessment of the variation in metal-line equivalent width W_r as a
function of sight-line separation. We measure differences in W_r,2796 of <40%
across all sight-line pairs subtending 7-21 kpc, suggestive of a high degree of
spatial coherence for MgII-absorbing material. W_r,2600 is observed to vary by
>50% over the same scales across the majority of sight-line pairs, while CIV
absorption exhibits a wide range in W_r,1548 differences of ~5-80% within
transverse distances less than ~3 kpc. J014709+463037 is one of only a handful
of z > 2 quadruply lensed systems for which all four source images are very
bright (r = 15.4-17.7 mag) and are easily separated in ground-based seeing
conditions. As such, it is an ideal candidate for higher-resolution
spectroscopy probing the spatial variation in the kinematic structure and
physical state of intervening absorbers.Comment: Submitted to ApJL. 9 pages, 3 figures. Uses aastex61 forma
A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.
Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system required for inducible aneuploidy in a human pathogen. Candida albicans utilizes chromosome missegregation to acquire tolerance to antifungal drugs and for nonmeiotic ploidy reduction after mating. We discovered that the ancestor of C. albicans and 2 related pathogens evolved a variant of histone 2A (H2A) that lacks the conserved phosphorylation site for kinetochore-associated Bub1 kinase, a key regulator of chromosome segregation. Using engineered strains, we show that the relative gene dosage of this variant versus canonical H2A controls the fidelity of chromosome segregation and the rate of acquisition of tolerance to antifungal drugs via aneuploidy. Furthermore, whole-genome chromatin precipitation analysis reveals that Centromere Protein A/ Centromeric Histone H3-like Protein (CENP-A/Cse4), a centromeric histone H3 variant that forms the platform of the eukaryotic kinetochore, is depleted from tetraploid-mating products relative to diploid parents and is virtually eliminated from cells exposed to aneuploidy-promoting cues. We conclude that genetically programmed and environmentally induced changes in chromatin can confer the capacity for enhanced evolvability via chromosome missegregation
Non-equilibrium dynamics and floral trait interactions shape extant angiosperm diversity.
Why are some traits and trait combinations exceptionally common across the tree of life, whereas others are vanishingly rare? The distribution of trait diversity across a clade at any time depends on the ancestral state of the clade, the rate at which new phenotypes evolve, the differences in speciation and extinction rates across lineages, and whether an equilibrium has been reached. Here we examine the role of transition rates, differential diversification (speciation minus extinction) and non-equilibrium dynamics on the evolutionary history of angiosperms, a clade well known for the abundance of some trait combinations and the rarity of others. Our analysis reveals that three character states (corolla present, bilateral symmetry, reduced stamen number) act synergistically as a key innovation, doubling diversification rates for lineages in which this combination occurs. However, this combination is currently less common than predicted at equilibrium because the individual characters evolve infrequently. Simulations suggest that angiosperms will remain far from the equilibrium frequencies of character states well into the future. Such non-equilibrium dynamics may be common when major innovations evolve rarely, allowing lineages with ancestral forms to persist, and even outnumber those with diversification-enhancing states, for tens of millions of years
The Large, Oxygen-Rich Halos of Star-Forming Galaxies Are A Major Reservoir of Galactic Metals
The circumgalactic medium (CGM) is fed by galaxy outflows and accretion of
intergalactic gas, but its mass, heavy element enrichment, and relation to
galaxy properties are poorly constrained by observations. In a survey of the
outskirts of 42 galaxies with the Cosmic Origins Spectrograph onboard the
Hubble Space Telescope, we detected ubiquitous, large (150 kiloparsec) halos of
ionized oxygen surrounding star-forming galaxies, but we find much less ionized
oxygen around galaxies with little or no star formation. This ionized CGM
contains a substantial mass of heavy elements and gas, perhaps far exceeding
the reservoirs of gas in the galaxies themselves. It is a basic component of
nearly all star-forming galaxies that is removed or transformed during the
quenching of star formation and the transition to passive evolution.Comment: This paper is part of a set of three papers on circumgalactic gas
observed with the Cosmic Origins Spectrograph on HST, to be published in
Science, together with related papers by Tripp et al. and Lehner & Howk, in
the November 18, 2011 edition. This version has not undergone final
copyediting. Please see Science online for the final printed versio
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