Low-profile independently- and concurrently-tunable quad-band antenna for single chain sub-6GHz 5G new radio applications

This paper presents a quad-band frequency agile antenna, with independent and concurrent frequency tunability in each band, for a tunable, concurrent, quad-band single chain radio receiver for 5G New Radio (NR). More specifically, the antenna comprises of four planar slots etched in a ground plane and fed through a single microstrip feedline, without any impedance matching network. The structure is optimized to maximize isolation between the individual slots and their respective resonant frequencies. Furthermore, a novel high order harmonic suppression method is demonstrated, which controls the current distribution via creating a fictitious short circuit in the slot antenna-enabling the antenna to achieve a much wider tuning range. Numerical simulations are verified using experimental implementation and measurements, with good agreement observed. The four slots resonate around the 830 MHz, 1.8 GHz, 2.4 GHz and 3.4 GHz frequency bands, which are independently tuned (using a varactor diode in each slot) to achieve tuning ranges of approximately 64%, 66%, 27% and 33%, respectively. More importantly, the contiguous four bands covers a total frequency tuning from 0.6 to 3.6 GHz i.e. a tuning range of approximately 143%. Finally, far-field measurements are performed and the antenna is evaluated in over-the-air testbed (quad-band radio receiver), which measures the Error Vector Magnitude performance for the individual channels. Good performance is observed, confirming acceptable isolation performance between the four bands. The data reported in this paper is available, from ORDA-The University of Sheffield Research Data Catalogue and Repository, at https://doi.org/10.15131/shef.data.11219000.v1

Tri-band single chain radio receiver for concurrent radio

The bandwidth available for improving throughputs to future mobile devices at sub-6 GHz frequencies can be increased through aggregating multiple non-contiguous bands, which may be using the same or different radio access technologies to transmit information. However, with conventional radio technology, a complete radio frequency (RF) chain is required for each band, limiting the possible increase due to space and energy consumption restraints in the mobile station (MS). This paper presents and measures a single RF chain radio for concurrent reception of three non-contiguous bands transmitting 16-QAM LTE signals, using a tunable analogue front-end and software defined radio (SDR) techniques. The receiver sensitivity is degraded by only 6dB under worst-case concurrent reception, compared with reception of a single band. This demonstrates that complex signaling techniques can be received concurrently with a single radio chain while meeting the 3GPP standards, opening the way to compact, efficient, multiband receivers for future standards

Pre-M Phase-promoting Factor Associates with Annulate Lamellae in Xenopus Oocytes and Egg Extracts

We have used complementary biochemical and in vivo approaches to study the compartmentalization of M phase-promoting factor (MPF) in prophase Xenopus eggs and oocytes. We first examined the distribution of MPF (Cdc2/CyclinB2) and membranous organelles in high-speed extracts of Xenopus eggs made during mitotic prophase. These extracts were found to lack mitochondria, Golgi membranes, and most endoplasmic reticulum (ER) but to contain the bulk of the pre-MPF pool. This pre-MPF could be pelleted by further centrifugation along with components necessary to activate it. On activation, Cdc2/CyclinB2 moved into the soluble fraction. Electron microscopy and Western blot analysis showed that the pre-MPF pellet contained a specific ER subdomain comprising "annulate lamellae" (AL): stacked ER membranes highly enriched in nuclear pores. Colocalization of pre-MPF with AL was demonstrated by anti-CyclinB2 immunofluorescence in prophase oocytes, in which AL are positioned close to the vegetal surface. Green fluorescent protein-CyclinB2 expressed in oocytes also localized at AL. These data suggest that inactive MPF associates with nuclear envelope components just before activation. This association may explain why nuclei and centrosomes stimulate MPF activation and provide a mechanism for targeting of MPF to some of its key substrates

Study protocol for preventing early-onset pneumonia in young children through maternal immunisation: a multi-centre randomised controlled trial (PneuMatters)

Background: Preventing and/or reducing acute lower respiratory infections (ALRIs) in young children will lead to substantial short and long-term clinical benefits. While immunisation with pneumococcal conjugate vaccines (PCV) reduces paediatric ALRIs, its efficacy for reducing infant ALRIs following maternal immunisation has not been studied. Compared to other PCVs, the 10-valent pneumococcal-Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) is unique as it includes target antigens from two common lower airway pathogens, pneumococcal capsular polysaccharides and protein D, which is a conserved H. influenzae outer membrane lipoprotein. Aims: The primary aim of this randomised controlled trial (RCT) is to determine whether vaccinating pregnant women with PHiD-CV (compared to controls) reduces ALRIs in their infants' first year of life. Our secondary aims are to evaluate the impact of maternal PHiD-CV vaccination on different ALRI definitions and, in a subgroup, the infants' nasopharyngeal carriage of pneumococci and H. influenzae, and their immune responses to pneumococcal vaccine type serotypes and protein D. Methods: We are undertaking a parallel, multicentre, superiority RCT (1:1 allocation) at four sites across two countries (Australia, Malaysia). Healthy pregnant Australian First Nation or Malaysian women aged 17-40 years with singleton pregnancies between 27+6 and 34+6 weeks gestation are randomly assigned to receive either a single dose of PHiD-CV or usual care. Treatment allocation is concealed. Study outcome assessors are blinded to treatment arms. Our primary outcome is the rate of medically attended ALRIs by 12-months of age. Blood and nasopharyngeal swabs are collected from infants at birth, and at ages 6- and 12-months (in a subset). Our planned sample size (n = 292) provides 88% power (includes 10% anticipated loss to follow-up). Discussion: Results from this RCT potentially leads to prevention of early and recurrent ALRIs and thus preservation of lung health during the infant's vulnerable period when lung growth is maximum. The multicentre nature of our study increases the generalisability of its future findings and is complemented by assessing the microbiological and immunological outcomes in a subset of infants. Clinical Trial Registration: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374381, identifier: ACTRN12618000150246.Anne B. Chang, Maree Toombs, Mark D. Chatfield, Remai Mitchell, Siew M. Fong, Michael J. Binks ... at al

Tuning range enhancement of a frequency-agile tri-band slot antenna

A low-profile tri-band slot antenna with enhanced tuning range is presented in this paper. Tri-band frequency agility is obtained using three varactor-loaded slots on a planar structure. The tuning range of the proposed antenna is enhanced by suppressing the higher-order resonance modes, especially by controlling the surface currents and creating a fictitious ground on the antenna. Following full-wave simulations, a prototype was developed and measured to validate the concept. Results show a tuning range from 600MHz to 3300MHz, which is a 600 MHz increase in the overall tuning range than previously reported

Planar frequency-tunable quad-band antenna with independently controllable bands

A low-profile quad-band loaded-slot antenna with independently controllable frequency bands is presented in this paper. Four slots are carefully designed to generate four separate frequency resonances, which were independently tuned by employing varactor diodes in each slot. The proposed concept was simulated using a full-wave solver and validated through measurements. The results show that each of the four bands can be independently controlled by altering the bias voltage of the respective varactor diode. Overall, the measured frequency tuning of the 1st, 2nd, 3rd, and 4th bands were 450–750 MHz, 600–1200 MHz, 1200–2100 MHz and 2100–2700 MHz, respectively. The proposed antenna has good potential for applications in the concurrently tunable multiband radio systems, including 5G