591 research outputs found

    Connecting Urban Students with their Rivers Generates Interest and Skills in the Geosciences

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    This article provides an overview of two different enrichment programs for urban high school students from the Greater Hartford Area of Connecticut that were conducted during the summer of 2002. They were designed to expose students entering the tenth grade to Earth Science as a problem solving science in a challenging and supportive atmosphere. This was done by focusing on understanding watersheds and water quality using primarily chemical techniques on samples collected from the Connecticut River and adjacent waters. The students worked in groups of one to three and student-faculty ratios that did not exceed three to one provided close supervision and individual attention. The majority of the students indicated that the programs were a positive experience and that they developed a greater appreciation for the science and would recommend these programs to other students. Educational levels: Graduate or professional

    'The undiluted squash of UK math rock': the performer's view of ArcTanGent festival

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    In its promotional materials ArcTanGent describes itself as ā€˜the worldā€™s ultimate music festival for the alternative of the alternative.ā€™ August 2017 saw the festival sell out its fifth instalment, attracting five thousand attendees to a farm south of Bristol. Its competitive booking of internationally-recognised acts makes ArcTanGent an unmissable event for fans of math, post, and noise rock, many of whom play in bands and aspire to perform at the festival themselves. In the case of the largely DIY UK math rock scene, this aspiration derives in part from ArcTanGentā€™s assumption of congressional status among members. Not only does it provide a platform for lesser known bands to promote themselves to an engaged audience, it also presents an opportunity for scene stakeholders from around the country to interact socially and strengthen networks. This article draws upon multiple interviews, primarily with three bands on ArcTanGentā€™s 2017 line-up, to provide an overview of the ways in which it is perceived by performers within the UK math rock scene. The findings of these interviews expose similarities, but also some notable differences, in each subjectā€™s experience of the festival: the excitement and positivity of ā€˜noviceā€™ bands contrasts with the limitations and sense of routine felt by ā€˜veterans.ā€™ The bandsā€™ levels of engagement with the event also serve to demonstrate that in its short period of existence ArcTanGent has become an important pillar in the structure of this underground scene, leading to a sense of community developing among participants. However, in comparing the festival with the everyday there is recognition among bands that it presents a ā€˜falsified senseā€™ of their popularity, posing the question of whether ArcTanGent has done more harm than good to the commercial progression of the UK math rock scene; an argument which is currently being played out in the sceneā€™s blogosphere

    The use of unsecured debt in REITs

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    Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 1995.Includes bibliographical references (leaves 54-56).by Michael J. O'Connell.M.S

    Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice

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    INTRODUCTION Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways confer resistance to mammary tumors in a mouse model of Li-Fraumeni syndrome. METHODS Mice that differ in p53 status (Trp53+/+, Trp53+/-, Trp53-/-) were treated with E+P for 14 days and then were tested for p53-dependent responses to ionizing radiation. Responses were also examined in parous and age-matched virgins. The effects of hormonal exposures on tumor incidence were examined in BALB/c-Trp53+/- mammary tissues. RESULTS Nuclear accumulation of p53 and apoptotic responses were increased similarly in the mammary epithelium from E+P-treated and parous mice compared with placebo and age-matched virgins. This effect was sustained for at least 7 weeks after E+P treatment and did not depend on the continued presence of ovarian hormones. Hormone stimulation also enhanced apoptotic responses to ionizing radiation in BALB/c-Trp53+/- mice but these responses were intermediate compared with Trp53+/+ and Trp-/- tissues, indicating haploinsufficiency. The appearance of spontaneous mammary tumors was delayed by parity in BALB/c-Trp53+/- mice. The majority of tumors lacked estrogen receptor (ER), but ER+ tumors were observed in both nulliparous and parous mice. However, apoptotic responses to ionizing radiation and tumor incidence did not differ among outgrowths of epithelial transplants from E+P-treated donors and nulliparous donors. CONCLUSION Therefore, E+P and parity confer a sustained increase in p53-mediated apoptosis within the mammary epithelium and suppress mammary tumorigenesis, but this effect was not retained in epithelial outgrowths.This work was supported by grants from the US Army Medical Research and Materiel Command (W81XWH0410385 to KAD and DAMD17-01-1-0315 to ACB) and the National Institutes of Health (RO1-CA095164 to DJJ)

    'The undiluted squash of UK math rock': the performer's view of ArcTanGent festival

    Get PDF
    In its promotional materials ArcTanGent describes itself as ā€˜the worldā€™s ultimate music festival for the alternative of the alternative.ā€™ August 2017 saw the festival sell out its fifth instalment, attracting five thousand attendees to a farm south of Bristol. Its competitive booking of internationally-recognised acts makes ArcTanGent an unmissable event for fans of math, post, and noise rock, many of whom play in bands and aspire to perform at the festival themselves. In the case of the largely DIY UK math rock scene, this aspiration derives in part from ArcTanGentā€™s assumption of congressional status among members. Not only does it provide a platform for lesser known bands to promote themselves to an engaged audience, it also presents an opportunity for scene stakeholders from around the country to interact socially and strengthen networks. This article draws upon multiple interviews, primarily with three bands on ArcTanGentā€™s 2017 line-up, to provide an overview of the ways in which it is perceived by performers within the UK math rock scene. The findings of these interviews expose similarities, but also some notable differences, in each subjectā€™s experience of the festival: the excitement and positivity of ā€˜noviceā€™ bands contrasts with the limitations and sense of routine felt by ā€˜veterans.ā€™ The bandsā€™ levels of engagement with the event also serve to demonstrate that in its short period of existence ArcTanGent has become an important pillar in the structure of this underground scene, leading to a sense of community developing among participants. However, in comparing the festival with the everyday there is recognition among bands that it presents a ā€˜falsified senseā€™ of their popularity, posing the question of whether ArcTanGent has done more harm than good to the commercial progression of the UK math rock scene; an argument which is currently being played out in the sceneā€™s blogosphere

    Organic functionalisation, doping and characterisation of semiconductor surfaces for future CMOS device applications

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    Organic Functionalisation, Doping and Characterisation of Semiconductor Surfaces for Future CMOS Device Applications Semiconductor materials have long been the driving force for the advancement of technology since their inception in the mid-20th century. Traditionally, micro-electronic devices based upon these materials have scaled down in size and doubled in transistor density in accordance with the well-known Mooreā€™s law, enabling consumer products with outstanding computational power at lower costs and with smaller footprints. According to the International Technology Roadmap for Semiconductors (ITRS), the scaling of metal-oxide-semiconductor field-effect transistors (MOSFETs) is proceeding at a rapid pace and will reach sub-10 nm dimensions in the coming years. This scaling presents many challenges, not only in terms of metrology but also in terms of the material preparation especially with respect to doping, leading to the moniker ā€œMore-than-Mooreā€. Current transistor technologies are based on the use of semiconductor junctions formed by the introduction of dopant atoms into the material using various methodologies and at device sizes below 10 nm, high concentration gradients become a necessity. Doping, the controlled and purposeful addition of impurities to a semiconductor, is one of the most important steps in the material preparation with uniform and confined doping to form ultra-shallow junctions at source and drain extension regions being one of the key enablers for the continued scaling of devices. Monolayer doping has shown promise to satisfy the need to conformally dope at such small feature sizes. Monolayer doping (MLD) has been shown to satisfy the requirements for extended defect-free, conformal and controllable doping on many materials ranging from the traditional silicon and germanium devices to emerging replacement materials such as III-V compounds This thesis aims to investigate the potential of monolayer doping to complement or replace conventional doping technologies currently in use in CMOS fabrication facilities across the world
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