10 research outputs found

    Design and construction of the MicroBooNE detector

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    This paper describes the design and construction of the MicroBooNE liquid argon time projection chamber and associated systems. MicroBooNE is the first phase of the Short Baseline Neutrino program, located at Fermilab, and will utilize the capabilities of liquid argon detectors to examine a rich assortment of physics topics. In this document details of design specifications, assembly procedures, and acceptance tests are reported

    EXPERIMENTAL SALMONELLA ANATUM INFECTION IN HORSES

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    SUMMARY Salmonella anatum was given orally to 8 horses on 11 occasions in doses ranging from 9.5 × 106 to 8.8 × 1011 organisms. Four distinct syndromes were induced based upon clinical, laboratory and pathological findings: (1) asymptomatic; (2) moderate clinical signs with or without changes in faecal consistency; (3) fever, depression, anorexia with unstructured or diarrhoeic faeces; and (4) septicaemia with or without diarrhoea, and peripheral circulatory failure. All animals excreted the organism. The peak temperature preceded the onset of diarrhoea by 1 or 2 days. Changes in faecal consistency were associated with direct isolation of the organism. The degree of neutropaenia increased with the dosage. Blood cultures were unsatisfactory, only 1 of 33 samples being positive. The serological responses were not significant although one animal displayed a significant seroconversion consistent with the clinical reaction. Indomethacin was not of value in moderating intestinal fluid secretion in one animal. The distribution and quantitation of positive cultures at autopsy closely reflected the type of syndrome induced. The invasiveness of the organism was confirmed by frequent direct recoveries from intestinal wall and draining lymph node samples. S. anatum appears to be of similar pathogenicity to S. typhimurium in the horse, at least under experimental conditions. Copyrigh

    The ecology of the European badger (Meles meles) in Ireland: a review

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    peer-reviewedThe badger is an ecologically and economically important species. Detailed knowledge of aspects of the ecology of this animal in Ireland has only emerged through research over recent decades. Here, we review what is known about the species' Irish populations and compare these findings with populations in Britain and Europe. Like populations elsewhere, setts are preferentially constructed on south or southeast facing sloping ground in well-drained soil types. Unlike in Britain, Irish badger main setts are less complex and most commonly found in hedgerows. Badgers utilise many habitat types, but greater badger densities have been associated with landscapes with high proportions of pasture and broadleaf woodlands. Badgers in Ireland tend to have seasonally varied diets, with less dependence on earthworms than some other populations in northwest Europe. Recent research suggests that females exhibit later onset and timing of reproductive events, smaller litter sizes and lower loss of blastocysts than populations studied in Britain. Adult social groups in Ireland tend to be smaller than in Britain, though significantly larger than social groups from continental Europe. Although progress has been made in estimating the distribution and density of badger populations, national population estimates have varied widely in the Republic of Ireland. Future research should concentrate on filling gaps in our knowledge, including population models and predictive spatial modelling that will contribute to vaccine delivery, management and conservation strategies.Department of Agriculture, Fisheries and FoodTeagasc Walsh Fellowship Programm

    Protein glycosylation in cancer biology: an overview

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