11,868 research outputs found
Protein-nucleic acids interactions: new ways of connecting structure, dynamics and function
No abstract available
The Economics of Small Worlds
We examine a simple economic model of network formation where agents benefit from indirect relationships. We show that small-world featuresâshort path lengths between nodes together with highly clustered link structuresânecessarily emerge for a wide set of parameters
The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal
We have identified a conserved nuclear pore localisation signal (NPLS; amino acids 764â838 of EPAC1) in the catalytic domains of the cAMP-sensors, EPAC1 and EPAC2A. Consequently, EPAC1 is mainly localised to the nuclear pore complex in HEK293T cells where it becomes activated following stimulation with cAMP. In contrast, structural models indicate that the cAMP-binding domain of EPAC2A (CNBD1) blocks access to the conserved NPLS in EPAC2A, reducing its ability to interact with nuclear binding sites. Consequently, a naturally occurring EPAC2 isoform, EPAC2B, which lacks CNBD1 is enriched in nuclear fractions, similar to EPAC1. Structural differences in EPAC isoforms may therefore determine their intracellular location and their response to elevations in intracellular cAMP
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