1 research outputs found
CNS Depressant Effect of the Crude Ethanolic Extract of the Flowering Tops of Rosa Damascena Â
The ethanolic extract of the flowering tops of Rosa Damascena Â
(Rosaceae) was assessed for effect on the central nervous system (CNS)
using a number of neuropharmacological experimental models in mice. The
extract produced a dose-dependent reduction of the onset and duration
of pentobarbitone-induced hypnosis, reduction of locomotor and
exploratory activities in the open field, hole cross tests. At the same
dose levels, the extract dose-dependently inhibited acetic acid-induced
writhing in mice. These results suggest that the extract possess CNS
depressant activity