Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
Abstract
The ethanolic extract of the flowering tops of Rosa Damascena
(Rosaceae) was assessed for effect on the central nervous system (CNS)
using a number of neuropharmacological experimental models in mice. The
extract produced a dose-dependent reduction of the onset and duration
of pentobarbitone-induced hypnosis, reduction of locomotor and
exploratory activities in the open field, hole cross tests. At the same
dose levels, the extract dose-dependently inhibited acetic acid-induced
writhing in mice. These results suggest that the extract possess CNS
depressant activity