Kaempulchraols A–H, Diterpenoids from the Rhizomes of <i>Kaempferia pulchra</i> Collected in Myanmar

Eight new diterpenoids, kaempulchraols A–H (<b>1</b>–<b>8</b>), along with five known analogues were isolated from the CHCl₃-soluble extract of rhizomes of <i>Kaempferia pulchra</i> of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer; MDA-MB-231, human breast cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (<b>6</b>) exhibited weak activity against the human pancreatic PSN-1 cell line with an IC₅₀ value of 12.3 μM

A new sterol from the Vietnamese marine sponge <i>Xestospongia testudinaria</i> and its biological activities

<p>A new sterol, langcosterol A (<b>1</b>), together with two known sterols <b>2</b> and <b>3</b>, were isolated from the marine sponge <i>Xestospongia testudinaria</i> collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound <b>1</b> and the known compound <b>3</b> exhibited moderate cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervical cancer) and a human normal cell line (WI-38 fibroblast), with IC₅₀ values ranging from 29.0 to 68.0 μM.</p

Kaempulchraols P–T, Diterpenoids from <i>Kaempferia pulchra</i> Rhizomes Collected in Myanmar

The isolation of the oily fraction obtained from the CHCl₃-soluble extract of the rhizomes of <i>Kaempferia pulchra</i> afforded five new isopimarane diterpenoids, kaempulchraols P–T (<b>1</b>–<b>5</b>), along with two known analogues. The structures were elucidated using spectroscopic techniques, including 2D NMR spectroscopy