APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson's disease

The relationship between APOE polymorphisms and Parkinson's disease (PD) in black Africans has not been previously investigated. We evaluated the association between APOE polymorphic variability and self-declared cognition in 1100 Nigerians with PD and 1097 age-matched healthy controls. Cognition in PD was assessed using the single item cognition question (item 1.1) of the MDS-UPDRS. APOE genotype and allele frequencies did not differ between PD and controls (p > 0.05). No allelic or genotypic association was observed between APOE and age at onset of PD. In PD, APOE ε4/ε4 conferred a two-fold risk of cognitive impairment compared to one or no ε4 (HR: 2.09 (95% CI: 1.13-3.89; p = 0.02)), while APOE ε2 was associated with modest protection against cognitive impairment (HR: 0.41 (95% CI 0.19-0.99, p = 0.02)). Of 773 PD with motor phenotype and APOE characterized, tremor-dominant (TD) phenotype predominated significantly in ε2 carriers (87/135, 64.4%) compared to 22.2% in persons with postural instability/gait difficulty (PIGD) (30/135) and 13.3% in indeterminate (ID) (18/135, 13.3%) (p = 0.037). Although the frequency of the TD phenotype was highest in homozygous ε2 carriers (85.7%), the distribution of motor phenotypes across the six genotypes did not differ significantly (p = 0.18). Altogether, our findings support previous studies in other ethnicities, implying a role for APOE ε4 and ε2 as risk and protective factors, respectively, for cognitive impairment in PD

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Not AvailableThe genotoxic effects of commonly used agricultural pesticides viz., carbosulfan, glyphosate, and atrazine, were evaluated in Channa punctatus (Pisces, Perciformes) using micronucleus (MN) test and induction of nuclear lesions (NL). The 96 h LC50 value were estimated by probit analysis as 0.27, 32.0 and 42.0 mg L(-1), respectively, for carbosulfan, glyphosate, and atrazine using semi-static bioassays. Based on these values, three sublethal test concentrations of carbosulfan (0.07, 0.13, 0.20 mg L(-1)), glyphosate (8.1, 16.3, 24.4 mg L(-1)) and atrazine (10.6, 21.2, 31.8 mg L(-1)) corresponding to ¼, ½ and ¾ of the LC50 of the pesticides respectively, were selected for exposure for 96 h. Peripheral blood samplings were taken at intervals of 24 h for assessment of MN and NL frequencies. Considerably higher genotoxic damage was induced by carbosulfan as compared to glyphosate and atrazine. There were significant effects (p < 0.01) of concentrations in all the treated groups. The induction of MN and NL was highest at 96 h pesticide exposure at all test concentrations. The nuclear abnormalities recorded in this study, such as blebbed-, lobed-, notched- and bi-nuclei, other than micronuclei, are indicators of genotoxic damage.The Academy of Science for Developing World (TWAS) and the Department of Biotechnology, the Ministry of Science and Technology, Government of India (DBT) for the post-doctoral fellowshi

Effect of “Uchakiri”(Vitex doniana),“Uturukpa” (Pterocarpus santalinoides) and “Ewa” (Solanum americanum) Methanoic Extract on Iron Status of Rats

Background: Iron deficiency anaemia is a hidden hunger which can affect at every stage of human development especially pregnant women and children. Aim: The study was carried out to ascertain the effect of “ewa”, “uturukpa” and “uchakiri” on iron status of rat. Methods: The vegetables were purchased from Oriemba market Akpugo in Nkanu West Local Government Area of Enugu State. The vegetables were trimmed, washed with deionized water and drained. The vegetables were ground using electric blender. Methanolic extraction was done using a modified method. All the analysis were carried out using a standard method. Results: The results obtained were 2.67-3.52 mg iron, 0.52-0.89 mg copper, 1.56-7.43 mg zinc, 2.42-120.70 mg calcium 10.16-39.10 mg magnesium, and 68.80-90.40 mg potassium. The mean serum ferritin, haemoglobin, packed cell volume and RBC all increased gradually after consumption of leaves extract. Conclusion: The result showed that ethanol leaf extract of Vitex doniana, “ewa” and “uturukpa” posseses anti-anemic potentials that are capable of reducing the risk of iron deficiency anemia in the society