4 research outputs found

    Influence of brine treatment,drying methods and storage conditions on the microbial quality of freshwater snail (Lanistes libycus) meat.

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    Freshwater snail (Lanistes libycus) meat samples were subjected to four different preservation treatments (ovendried, sun-dried, brined oven-dried, brined sun-dried) and assessed for microbiological quality. The microbial quality of fresh or brine (5 % w/v NaCl) treated samples stored at different temperatures (35, 28, 4, -7 oC) were also investigated. Combining brine treatment with either ovendrying or sun-drying resulted in significant (p = 0.05) decrease in total viable counts (TVCs) of the meat with that of brined oven-dried samples being more pronounced (log10 3.92 cfu g-1) by day 4 of ambient storage. Sun-drying alone could not effectively preserve the meat beyond 2 days. No significant difference (p = 0.05) existed in the microbial loads of oven-dried and brined sun-dried samples stored at ambient temperature. The TVCs of all traditionally dried samples were microbiologically unacceptable (>(log10 5.0 cfu g-1) after 4 days of ambient storage with Bacillus, Clostridium, Staphylococcus sp and Aspergillus flavus being dominant microorganisms isolated. Whereasthe fresh meat of L. libycus treated with 5 % w/v NaCl and stored at low temperatures (4, -7 oC) exhibited drastic reduction in microbial load with shelf-life extension to 6 days, that stored at 28 oC preserved the meat for 4 days

    Optimization of Blended Guava and Fluted Pumpkin Leaves extract as corrosion inhibitor of mild steel in 0.5 m hydrochloric acid

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    There are many plant extracts that have been studied for possible use as corrosion inhibitors in the oil and gas industries. Hence, this work is focused on optimization of blended Guava and Fluted Pumpkin Leaves extract as corrosion inhibitor of mild steel in HCI using Weight loss method. Response Surface Methodology of Design Expert trial version 12 StatEase was used to design and analyze the result of the 35-run experiments. Three factor-three level was adopted in the design. Time, Temperature and Inhibitor Quantity were the independent variables, while the acid concentration of 0.5M was constant throughout the experiments and Inhibition Efficiencies were measured using IE formula. Intervals of 1 hr, 0.2g, and 10°C were chosen for the immersion time, inhibitor quantity and temperature, respectively. Phytochemical analysis carried out on the Guava and Fluted Pumpkin Leaves shows that each leaf extract contains phytochemicals which are responsible for inhibiting corrosion. Weight loss result shows that the Blended extract reduces the corrosion rate of mild steel in 0.5M HCl. Additionally, 4 experiments for Blended Extract, Fluted Pumpkin, Guava Extract and Industrial Inhibitor were carried out at optimal conditions as predicted by the software at time 4.036 hr, temperature 49.5°C, inhibitor quantity 0.487g and ratio of 59.21GE:FP40.79 Inhibition Efficiencies of the Blended, Fluted Pumpkin, Guava Extracts and Industrial Inhibitor were 93.70%, 78.14%, 63.7% and 95.18%, respectively. The results show that the blended and Industrial Inhibitor compared well with the software predicted IE of 96.085%. Therefore, the blended extract could serve as good substitute to the industrial inhibitor

    Use of beverages in the administration of artemether lumefantrin in drug resistant Plasmodium berghei malaria infection

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    Oral administration of antimalarials with beverages instead of water to evade drug odour and taste may undermine the current gains recorded in the fight against malaria if the associated drug-nutrient interaction compromises its efficacy. This study determined changes in blood chemistry and parasitaemia of Plasmodium passaged mice treated with artemether lumefantrin administered with selected locally consumed beverages. Using Rane’s test, 40 albino mice inoculated with quinine resistant Q (N1923) Plasmodium berghei were randomized into eight groups of five mice and treated with water and 1.14/6.85 mg/kg artemether lumefantrin co-administered with water, coconut water, Nescafe® solution, coca cola, aqueous extract of Hibiscus sabdariffa calyces (zobo) and Lipton® teabag from day 3 to day 5. Antimalarial activity was determined from tail blood smears on day 3 just before treatment and on day 6 and 9. Treatment commenced from day 3 today 5. Liver and kidney function and lipid parameters were determined using standard methods. Data were analyzed for significance of disparity using one-way analysis of variance at 95 % confidence level. Results revealed that coconut water, Lipton and Zobo aqueous extract co-administration with artemeter lumefantrin treatment significantly (p<0.05) reduced and cleared parasitaemia by day 9 like the water administration treatment. The ACT co-administration with aqueous Lipton teabag extracts and coconut water increased triglycerides and HDL levels while there was no significant change (p>0.05) in the other lipids parameters. Liver and kidney function parameters were not significantly different (p>0.05) in the beverage administered treatment when compared to the water administered treatment. Drug-nutrient interaction of artemether lumefantrin with plant derived beverages did not compromise its efficacy and safety.Keywords: drug resistance, arthemeter lumefantrin, beverages, nutrient
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