33 research outputs found

    Progress towards nitride blue and near-UV VCSELs

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    AbstractAdvances in nitride-based blue and violet light emitters - most notably high-efficiency LEDs and edge-emitting diode lasters - now suggest possibilities for more advanced types of geometry such as those based on vertical-cavity surface-emitting structures

    Detection of Optogenetic Stimulation in Somatosensory Cortex by Non-Human Primates - Towards Artificial Tactile Sensation

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    Neuroprosthesis research aims to enable communication between the brain and external assistive devices while restoring lost functionality such as occurs from stroke, spinal cord injury or neurodegenerative diseases. In future closed-loop sensorimotor prostheses, one approach is to use neuromodulation as direct stimulus to the brain to compensate for a lost sensory function and help the brain to integrate relevant information for commanding external devices via, e.g. movement intention. Current neuromodulation techniques rely mainly of electrical stimulation. Here we focus specifically on the question of eliciting a biomimetically relevant sense of touch by direct stimulus of the somatosensory cortex by introducing optogenetic techniques as an alternative to electrical stimulation. We demonstrate that light activated opsins can be introduced to target neurons in the somatosensory cortex of non-human primates and be optically activated to create a reliably detected sensation which the animal learns to interpret as a tactile sensation localized within the hand. The accomplishment highlighted here shows how optical stimulation of a relatively small group of mostly excitatory somatosensory neurons in the nonhuman primate brain is sufficient for eliciting a useful sensation from data acquired by simultaneous electrophysiology and from behavioral metrics. In this first report to date on optically neuromodulated behavior in the somatosensory cortex of nonhuman primates we do not yet dissect the details of the sensation the animals exerience or contrast it to those evoked by electrical stimulation, issues of considerable future interest

    Wireless Neurosensor for Full-Spectrum Electrophysiology Recordings during Free Behavior

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    SummaryBrain recordings in large animal models and humans typically rely on a tethered connection, which has restricted the spectrum of accessible experimental and clinical applications. To overcome this limitation, we have engineered a compact, lightweight, high data rate wireless neurosensor capable of recording the full spectrum of electrophysiological signals from the cortex of mobile subjects. The wireless communication system exploits a spatially distributed network of synchronized receivers that is scalable to hundreds of channels and vast environments. To demonstrate the versatility of our wireless neurosensor, we monitored cortical neuron populations in freely behaving nonhuman primates during natural locomotion and sleep-wake transitions in ecologically equivalent settings. The interface is electrically safe and compatible with the majority of existing neural probes, which may support previously inaccessible experimental and clinical research

    Nanotools for Neuroscience and Brain Activity Mapping

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    Neuroscience is at a crossroads. Great effort is being invested into deciphering specific neural interactions and circuits. At the same time, there exist few general theories or principles that explain brain function. We attribute this disparity, in part, to limitations in current methodologies. Traditional neurophysiological approaches record the activities of one neuron or a few neurons at a time. Neurochemical approaches focus on single neurotransmitters. Yet, there is an increasing realization that neural circuits operate at emergent levels, where the interactions between hundreds or thousands of neurons, utilizing multiple chemical transmitters, generate functional states. Brains function at the nanoscale, so tools to study brains must ultimately operate at this scale, as well. Nanoscience and nanotechnology are poised to provide a rich toolkit of novel methods to explore brain function by enabling simultaneous measurement and manipulation of activity of thousands or even millions of neurons. We and others refer to this goal as the Brain Activity Mapping Project. In this Nano Focus, we discuss how recent developments in nanoscale analysis tools and in the design and synthesis of nanomaterials have generated optical, electrical, and chemical methods that can readily be adapted for use in neuroscience. These approaches represent exciting areas of technical development and research. Moreover, unique opportunities exist for nanoscientists, nanotechnologists, and other physical scientists and engineers to contribute to tackling the challenging problems involved in understanding the fundamentals of brain function

    Molecular Beam Epitaxy of II-VI Based Heterostructures

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    The nonequilibrium growth technique of molecular beam epitaxy (MBE) has provided for the fabrication and investigation of a multitude of novel layered heterostructures based on II-VI compound semiconductors. The ability to grow epitaxial metastable magnetic and semimagnetic semiconductors layered with conventional II-VI semiconductors has resulted in structures which, for example, exhibit frustrated antiferromagnetism, and a wide wavelength tunability due to selftrapping of excitons in ZnTe-containing layered structures and due to extremely large (≈ 1 eV) quantum shifts of light emission from MnTe/CdTe superlattice structures. In addition, the control in the stoichiometry of surfaces and the composition of molecular beams used in the MBE growth technique has allowed for the fabrication of very advanced heterostructures which have combined the II-VI and III-V families of compound semiconductors. The work which will be described in the following review represents a very small sampling of the many important results achieved in the field of II-VI based heterostructures. The topics have been selected to illustrate and provide an example of the utility of MBE and the potential of "engineered" II-VI heterostructures and quantum wells
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