The Relationship Between SYNTAX II Score and Serum Pleiotrophin Level in Patients with Non-ST-Segment Elevation Myocardial Infarction

Background and Aim: In this study, we aimed to examine the relationship between serum pleiotrophin (PTH) levels at admission and the severity of coronary artery disease (CAD) in patients experiencing non-ST-segment elevation myocardial infarction (NSTEMI). Materials and Methods: A total of 140 patients with NSTEMI undergoing coronary angiography were consecutively included in the study. The Synergy Between percutaneous coronary intervention with Taxus and Cardiac Surgery (SYNTAX) score was determined based on initial coronary angiography by at least two separate cardiologists. Results: A positive correlation was found between high SSII and PTH (r = 0.458; P < 0.001). PTH could anticipate the extremity of CAD with 64.4% sensitivity and 65.3% specificity at 250 ng/mL cut-off value (area under the curve: 0.718, 95% confidence interval, 54.8 - 74.7; P < 0.001). Through regression analysis, PTH, hypertension, diabetes mellitus, family history, lymphocyte count, and pro-brain natriuretic peptide levels were found to be independent predictors of SSII. Conclusion: In patients with NSTEMI, serum PTH levels were significantly associated with higher SSII, an indicator of CAD severity and cardiovascular prognosis. This study obtained positive results that will contribute to our clinical interpretation. More comprehensive studies with PTH will make a more useful contribution to our clinical judgments

Türkiye'de koroner yoğun bakım ünitelerindeki hastane içi mortalite (MORCOR-TURK) çalışmasında hasta temel karakteristikleri ve öngördürücüleri

OBJECTIVE: The MORtality in CORonary Care Units in Türkiye (MORCOR-TURK) trial is a national registry evaluating predictors and rates of in-hospital mortality in coronary care unit (CCU) patients in Türkiye. This report describes the baseline demographic characteristics of patients recruited for the MORCOR-TURK trial. METHODS: The study is a multicenter, cross-sectional, prospective national registry that included 50 centers capable of 24-hour CCU service, selected from all seven geographic regions of Türkiye. All consecutive patients admitted to CCUs with cardiovascular emergencies between September 1-30, 2022, were prospectively enrolled. Baseline demographic characteristics, admission diagnoses, laboratory data, and cardiovascular risk factors were recorded. RESULTS: A total of 3,157 patients with a mean age of 65 years (range: 56-73) and 2,087 (66.1%) males were included in the analysis. Patients with arterial hypertension [1,864 patients (59%)], diabetes mellitus (DM) [1,184 (37.5%)], hyperlipidemia [1,120 (35.5%)], and smoking [1,093 (34.6%)] were noted. Non-ST elevation myocardial infarction (NSTEMI) was the leading cause of admission [1,187 patients (37.6%)], followed by ST elevation myocardial infarction (STEMI) in 742 patients (23.5%). Other frequent diagnoses included decompensated heart failure (HF) [339 patients (10.7%)] and arrhythmia [272 patients (8.6%)], respectively. Atrial fibrillation (AF) was the most common pathological rhythm [442 patients (14%)], and chest pain was the most common primary complaint [2,173 patients (68.8%)]. CONCLUSION: The most common admission diagnosis was acute coronary syndrome (ACS), particularly NSTEMI. Hypertension and DM were found to be the two leading risk factors, and AF was the most commonly seen pathological rhythm in all hospitalized patients. These findings may be useful in understanding the characteristics of patients admitted to CCUs and thus in taking precautions to decrease CCU admissions