POLİLAKTİK ASİT BİYOABSORBABL ADEZYON BARİYER FİLMİNİN KOBAYLARDAKİ NÖROTOKSİK ETKİSİNİN ARASTIRILMASI AMACIYLA ORTA KULAGA UYGULANMASI

Amaç: Bu çalısmada yara iyilesmesi sırasında komsu yüzeyler arasında adezyon gelisimini önleyen polilaktik asid (PLA) film bariyerin kobay orta kulagına etkilerinin odyometrik ve patolojik olarak incelenmesi amaçlanmıstır. Gereç ve yöntem: Bu amaçla 21 erkek albino kobay çalısmaya dahil edildi. Kobayların her birinin bir kulagı çalısmanın kontrol grubunu, diger kulagı PLA uygulanan grubu olusturdu. Genel anestezi altında kobayların kulak zarları mikroskopla degerlendirilerek isitsel beyin sapı cevap ölçümü (ABR) ile isitme esik degerleri ve dalga latansları bulundu. Takiben kobay timpanik bullasında bir pencere açılarak PLA orta kulaga yerlestirildi. Kontrol tarafında sadece bulla penceresi açıldı, her iki taraf da bonewax ile kapatıldı. Uygulama sonrası 1. ve 6. aylarda ABR ile esikler ve dalga latansları degerlendirildikten sonra kobaylar sakrifiye edilerek temporal kemiklere histopatolojik inceleme yapıldı. Bulgular: Kontrol ve PLA grupları karsılastırıldıgında uygulama öncesi ve uygulama sonrası 1. ay ABR ölçümlerinde isitme esikleri arasında anlamlı bir fark saptanmadı. 6. aydaki ölçümlerde esiklerde uzama görüldü, ancak dalga morfolojileri normaldi. Her iki tarafın dalga latansları arasında uygulama sonrası ölçümlerde uygulama öncesi ölçümlere oranla hafif uzama görülmesine ragmen, bu degerler istatistiksel olarak anlamlı kabul edilmedi(p>0,05). Her iki grupta da preoperatif ve 1. ay interpik latans degerleri karsılastırıldıgında anlamlı farklar saptanmazken, 6. ayda ölçülen interpik latanslarda her iki grupta da preoperatif sonuçlara göre uzama görüldü. Bu sonuçların cerrahi isleme ve tur travmasına baglı oldugu düsünüldü. Hiçbir ölçümde dalga morfolojisinde bozukluk saptanmadı. Patolojik incelemede normal bulguların yanı sıra inflamasyona ait nonspesifik degisiklikler de saptandı. Sonuç: PLA film bariyer kulak operasyonları olmak üzere çogu alanda kullanılabilecek, cerrahın isini kolaylastıran ve toksisitesi tespit edilmeyen, adezyonu engelleyici bir materyaldir

Closure of tympanic membrane perforations using repeated trichloracetic acid

Our aim in this study is to show the efficacy of trichloracetic acid cauterization in the tympanic membrane perforations. Between January 2002 and January 2012 central perforations in 160 ears of 142 cases were tried to be closed by repeated trichloracetic acid cauterization in one week interval followed by the placement of a piece of cigarette paper to the perforation site. In 98 of 137 ears (71.5 %) that followed-up for a desired period of time, perforation was closed after an average of 4.2 applications. No statistical relation was found between the success of treatment, and the age of patient, the site of perforation and previous history of otorrhea. It was shown that the width of perforation is an important factor in the success of treatment. [Med-Science 2016; 5(2.000): 544-6

An odontogenic cyst causing facial asymmetry: a case report

Radicular cysts are inflammatory in character and the most frequently seen of odontogenic cysts. As they are generally seen to grow painlessly, the first finding may be facial asymmetry. Although seen in every age group, they are most often seen in males aged 20-60 years. The patient reported here presented with complaints of swelling in the right cheek. On the paranasal sinus computed tomography, a cyst appeared to be completely filling the maxillary sinus and this was totally excised with a Caldwell-Luc approach. In the differential diagnosis of cystic masses of the maxillary sinus, there may be confusion with odontogenic cysts. Imaging methods can clearly define the localisation of cystic lesions within the sinus cavity, growth direction, bone tissue loss associated with lysis and osteocondensation. To prevent recurrence, it is necessary to completely remove regenerated mucosa and the residual cyst epithelium. [Med-Science 2016; 5(4.000): 1011-12

Plexiform neurofibroma: An uncommon cause of conductive-type hearing loss

Plexiform neurofibromas (PNs) are slow-growing, vascularised, limited, non-capsular benign tumours. They may cause functional impairments, cosmetic problems, and issues with pain or a sense of pressure. Involvement of the external ear canal, which can trigger conductive-type hearing loss and cosmetic problems, is rare. A 14-year-old male diagnosed with, and under follow-up for, type 1 neurofibromatosis presented with hearing loss and an auricle deformity caused by a mass on the postauricular region of the mastoid bone. This mass had grown gradually over the past 5 years and at the time of consultation completely filled the external ear canal, pushing the auricle forward. It was surgically removed. Postoperative histological examination allowed diagnosis of a plexiform neurofibroma. The external ear canal was successfully cleared, affording a good cosmetic outcome. Audiometric tests revealed that the air-bone gap had closed

Tympanic membrane perforation in the province of: A retrospective study

In the current study, a retrospective scan was made of patients presenting at our clinic over the last 10 years and those diagnosed with tympanic membrane perforation were evaluated in 2 separate groups as patients with Chronic suppurative otitis media (CSOM) and Traumatic tympanic membrane perforations (TTMP). In this study patients with tympanic membrane perforation were evaluated through a retrospective examination of patients presenting at the Ear, Nose and Throat Clinic between May 2006 and May 2016. The tympanic membrane perforations were examined in two separate groups; CSOM and TTMP. When these patients were grouped according to the diagnosis criteria, the CSOM group comprised 8,335 (1.13%) patients and the TTMP group 422 (0.06%) patients. These two groups were compared in respect of the items stated age, gender, laterality. When the considerable number of patients is taken into consideration, although the results do not completely show a prevalence rate, they can give preliminary information. [Med-Science 2018; 7(3.000): 540-3

An adjuvant therapy in cervical necrotising fasciitis: hyperbaric oxygen treatment

Kearn sayre syndrome (KSS) is a rare disease with a typical onset before 20 years and characterized by triad of chronic progressive external ophthalmoplegia, retinitis pigmentosa and progressive cardiac conduction abnormalities. The most important prognostic factor in KSS patients is the involvement of heart characterized by progressive degeneration of the conduction system. In patients with KSS, early diagnosis of cardiac involvement is very important because complete atrioventricular (AV) block may develop and it can be cause of sudden cardiac death. Herein we report a patient with KSS who presented with syncope due to complete AV block. [Med-Science 2016; 5(4.000): 1013-5

Apelin hormone level and its role in the etiology of sudden hearing loss

Sudden hearing loss (SHL) is a significant problem requiring emergency intervention; however, consensus on its diagnosis and treatment remains to be determined. Although several factors could cause SHL, its cause can only be determined in 10% of patients. Several approaches have been described for its treatment. The primary aim of treatment is to prevent cochlear hypoxia by increasing the partial O2 pressure in the perilymph. Apelin is an oxidative stress mediator. If apelin level changes are associated with SHL etiology, the protective and therapeutic effects of apelin can be beneficial. This study aimed to investigate the extent of influence of apelin hormone level changes in the SHL etiology. A total of 27 patients diagnosed with SHL and 26 healthy volunteers were evaluated as the patient and control groups, respectively. Apelin levels, biochemical parameters, and hemoglobin levels were measured. No difference was found between the patient and control groups in respect of apelin and other parameters. Although the study results did not show a statistically significant difference, the degree of hearing loss increased with decreased apelin levels in patients with SHL. Although not statistically significant, Apelin level was lower as the level of hearing loss increased in patients presenting with SHL. According to studies, it can be thought that patients with low apelin levels can be assumed to be less likely protected against inflammatory diseases related to oxidative stress. Therefore, further comprehensive and extensive clinical studies to examine apelin effect mechanisms should be performed. According to studies, the Apelin hormone shows a protective effect against inflammatory diseases caused by oxidative stress. In our study, there was no significant difference when Apelin hormone levels were compared with the patients with sudden hearing loss in the control group. However, due to the low number of patients to investigate the mechanisms of action of Apelin, more extensive and larger studies are needed. [Med-Science 2020; 9(3.000): 704-7