Correlation between Squamous Suture and Sylvian Fissure: Osirix DICOM Viewer Study

信州大学博士（医学）・学位論文・平成23年9月30日授与（甲第881号）・NUNUNG NUR RAHMAHArticleRahmah NN, Murata T, Yako T, Horiuchi T, Hongo K (2011) Correlation between Squamous Suture and Sylvian Fissure: Osirix DICOM Viewer Study. PLoS ONE 6(3): e18199. doi:10.1371/journal.pone.0018199journal articl

Expression of RECK in endothelial cells of glioma: comparison with CD34 and VEGF expressions

Angiogenesis is thought to be involved in the progression of glioma grades, and reversion-inducing cysteine-rich protein with Kazal motifs (RECK) has been said to be involved in maturation of vessels. In this study, we aimed to determine whether high micro-vessel density (MVD) expressed by RECK in glioma tissue is correlated with grades of glioma. We also compared RECK expression with that of the formerly known vessel marker, CD34, and vascular endothelial growth factor (VEGF). RECK, CD34, and VEGF immuno-reactivities of 72 glioma tissues were studied. RECK was seen in microvessels of glioma tissues. CD34 showed a similar pattern to RECK, whereas VEGF showed positive staining in cytoplasm of tumor cells and endothelial cells. Average MVD with RECK was 107.6 microvessels (range 7-290). RECK was positively correlated with grades of glioma. RECK and CD34 also showed a strong correlation (P = 0.001). Higher frequency of VEGF staining was also correlated with higher grade of glioma. This is the first study describing expression of RECK in glioma, and its angiogenesis-related nature may provide a potential therapeutic target for glioma treatment in the future.ArticleJOURNAL OF NEURO-ONCOLOGY. 107(3):559-564 (2012)journal articl

Reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase-9 are prognostic markers in skull base chordomas

Prognosis of chordomas is difficult to predict based solely on histological findings. The purpose of this study was to assess expressions of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and matrix metalloproteinase (MMP)-2, MMP-9 in skull base chordomas and to find out their correlations to outcome. Immunohistochemical study was performed in 19 samples (initial, n = 11; recurrent, n = 8) from 11 patients. The correlations among expression of RECK, MMP-2, MMP-9, and their prognostic values were analyzed. Significant correlation between RECK and MMP-9 was found, but there was no correlation found between MMP-2 and MMP-9. Higher MMP-9 expression significantly influenced outcome. Furthermore, MMP-9/RECK ratio showed significant correlation to outcome, showing their inverse relationship in the disease progress of skull base chordoma. RECK and MMP-9 can be valuable markers to predict prognosis in skull base chordomas.ArticleNEUROSURGICAL REVIEW. 33(2):167-173 (2010)journal articl

Revisit of aneurysm clip closing forces: comparison of titanium versus cobalt alloy clip

Although closing force of cobalt alloy clip is well studied, there is only little information of titanium alloy clip available in the literature. In the present study, we examined and compared closing forces of various types and points of cerebral titanium and cobalt aneurysm clips for cerebral aneurysms. Straight, temporary, bayonet, angled, and fenestrated titanium or cobalt alloy clips were tested by measuring the closing forces at various points along their blade length. Closing forces of all the tested clips linearly increased from tip to base of clip blades. Sugita Titanium II clips had bigger closing forces than Elgiloy clips in all type clips except for the temporary clips. The closing forces of Sugita Titanium II and Yasargil titanium clips were similar in straight permanent type clip although there were some differences in closing forces between other types of Sugita and Yasargil clips. Our data showed that the closing forces differed depending not only on manufacturers but also on materials and shapes.ArticleNEUROSURGICAL REVIEW. 36(1):133-137 (2013)journal articl

Hubungan Pembelajaran Keterampilan Klinis Secara Online dengan Kelulusan OSCE Pada Mahasiswa Angkatan 2019 Fakultas Kedokteran Universitas YARSI Serta Tinjauan Dalam Islam

Latar belakang: Keterampilan klinis adalah metode pembelajaran atau model pembelajaran untuk melatih pengetahuan (kognitif), sikap (afektif) dan keterampilan (psikomotor) melalui pemanfaatan fasilitas laboratorium yang dapat dilakukan secara online untuk mengurangi penyebaran penyakit COVID-19 yang dapat dinilai dengan Objective Structured Clinical Examination. Menurut pandangan islam, belajar merupakan sebuah kewajiban bagi setiap manusia, karena dengan media online manusia bisa meningkatkan kemampuan dirinya. Tujuan penelitian ini adalah untuk mengetahui hubungan antara pembelajaran keterampilan klinis secara online, usia, dan jenis kelamin dengan kelulusan OSCE online dan offline serta tinjauan dalam Islam. Metode: Jenis penelitian berupa deskriptif analitik dengan desain penelitian cross sectional. Kuesioner didistribusikan melalui google form. Penelitian ini dilakukan pada Mahasiswa Fakultas Kedokteran Universitas YARSI Angkatan 2019 dengan jumlah sampel sebanyak 145 responden. Analisis data menggunakan uji Kolmogorov-Smirnov. Hasil: Berdasarkan hasil uji statistik tidak terdapat hubungan yang bermakna antara pembelajaran keterampilan klinis secara online, jenis kelamin, usia dengan kelulusan OSCE online dan offline pada Mahasiswa Angkatan 2019 Fakultas Kedokteran Universitas YARSI. Kesimpulan: Tidak terdapat hubungan antara pembelajaran keterampilan klinis secara online, usia dan jenis kelamin dengan kelulusan OSCE online serta offline

Comparison of manual and digital microvascular density counting of RECK expression in glioma

A microvascular density (MVD) counting method for reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression, using a digital image analysis tool, has advantages over manual counting by microscope. Thirty glioma cases with RECK staining were photographed at a magnification of 200 x high power field and the photographs in RGB images were analyzed, and stained vessels were captured and were counted automatically. MVD with RECK expression using a digital image analysis tool showed comparable results to those of the manual method. RECK intensity expression could show linear correlation with grades of glioma by the digital method, which was superior compared to the manual method. The present method is recommended to researchers undertaking MVD study for glioma.ArticleNEUROPATHOLOGY. 32(3):245-251 (2012)journal articl

Pontine infarction caused by medial branch injury of the basilar artery as a rare complication of cisternal drain placement

We present a rare complication of cisternal drain placement during aneurysm surgery. A ruptured anterior communicating artery aneurysm was clipped through a right pterional approach. A cisternal drain was inserted from the retro-carotid to the prepontine cistern. Postoperatively, a left-sided paresis of the upper extremity had developed. A CT brain scan revealed that the drain was located between the pons and the basilar artery, resulting in a pontine infarction. Vascular neurosurgeons should keep this complication in mind when placing a cisternal drain tube. The drain tube should not be inserted too deep into the prepontine cistern.ArticleJOURNAL OF CLINICAL NEUROSCIENCE. 19(4):592-593 (2012)journal articl

Operation-Microscope-Mounted Touch Display Tablet Computer for Intraoperative Imaging Visualization

OBJECTIVE: The authors have developed a novel sterile draped touch display solution for convenient intraoperative access to imaging data. This study describes the technology and clinical experience of the system. METHODS: We developed a flexible, mounted touch display solution (Apple iPad) that allows fixation of the display on the operation microscope and fine adjustments during surgery when the microscope is moved. We compared this setup with a conventional wall-mounted flat-panel and a mobile display stand in illustrative cases of vestibular schwannoma. RESULTS: The surgeon was able to employ the system without the need to leave the operation field or the need for external assistance while referring to imaging data. Commanding through imaging data with sterile gloves on the touch display was more convenient, more precise, and faster compared with other modalities. CONCLUSION: The operation-microscope-mounted touch display provides useful assistance for intraoperative imaging visualization in neurosurgical procedures.ArticleWORLD NEUROSURGERY. 77(2):381-383 (2012)journal articl

Pontine infarction caused by medial branch injury of the basilar artery as a rare complication of cisternal drain placement

We present a rare complication of cisternal drain placement during aneurysm surgery. A ruptured anterior communicating artery aneurysm was clipped through a right pterional approach. A cisternal drain was inserted from the retro-carotid to the prepontine cistern. Postoperatively, a left-sided paresis of the upper extremity had developed. A CT brain scan revealed that the drain was located between the pons and the basilar artery, resulting in a pontine infarction. Vascular neurosurgeons should keep this complication in mind when placing a cisternal drain tube. The drain tube should not be inserted too deep into the prepontine cistern

Three-Dimensional Magnetic Resonance Imaging Based on Time-of-Flight Magnetic Resonance Angiography for Superficial Cerebral Arteriovenous Malformation -Technical Note-

Direct surgery remains important for the treatment of superficial cerebral arteriovenous malformation (AVM). Surgical planning on the basis of careful analysis from various neuroimaging modalities can aid in resection of superficial AVM with favorable outcome. Three-dimensional (3D) magnetic resonance (MR) imaging reconstructed from time-of-flight (TOF) MR angiography was developed as an adjunctive tool for surgical planning of superficial AVM. 3-T TOF MR imaging without contrast medium was performed preoperatively in patients with superficial AVM. The images were imported into OsiriX imaging software and the 3D reconstructed MR image was produced using the volume rendering method. This 3D MR image could clearly visualize the surface angioarchitecture of the AVM with the surrounding brain on a single image, and clarified feeding arteries including draining veins and the relationship with sulci or fissures surrounding the nidus. 3D MR image of the whole AVM angioarchitecture was also displayed by skeletonization of the surrounding brain. Preoperative 3D MR image corresponded to the intraoperative view. Feeders on the brain surface were easily confirmed and obliterated during surgery, with the aid of the 3D MR images. 3D MR imaging for surgical planning of superficial AVM is simple and noninvasive to perform, enhances intraoperative orientation, and is helpful for successful resection.ArticleNEUROLOGIA MEDICO-CHIRURGICA. 51(2):163-167 (2011)journal articl