5,396 research outputs found
Model of Low-pass Filtering of Local Field Potentials in Brain Tissue
Local field potentials (LFPs) are routinely measured experimentally in brain
tissue, and exhibit strong low-pass frequency filtering properties, with high
frequencies (such as action potentials) being visible only at very short
distances (10~) from the recording electrode. Understanding
this filtering is crucial to relate LFP signals with neuronal activity, but not
much is known about the exact mechanisms underlying this low-pass filtering. In
this paper, we investigate a possible biophysical mechanism for the low-pass
filtering properties of LFPs. We investigate the propagation of electric fields
and its frequency dependence close to the current source, i.e. at length scales
in the order of average interneuronal distance. We take into account the
presence of a high density of cellular membranes around current sources, such
as glial cells. By considering them as passive cells, we show that under the
influence of the electric source field, they respond by polarisation, i.e.,
creation of an induced field. Because of the finite velocity of ionic charge
movement, this polarization will not be instantaneous. Consequently, the
induced electric field will be frequency-dependent, and much reduced for high
frequencies. Our model establishes that with respect to frequency attenuation
properties, this situation is analogous to an equivalent RC-circuit, or better
a system of coupled RC-circuits. We present a number of numerical simulations
of induced electric field for biologically realistic values of parameters, and
show this frequency filtering effect as well as the attenuation of
extracellular potentials with distance. We suggest that induced electric fields
in passive cells surrounding neurons is the physical origin of frequency
filtering properties of LFPs.Comment: 10 figs, revised tex file and revised fig
Effective t-J Hamiltonian for the Copper Oxides
Starting from the Emery model, which is assumed to describe the copper oxygen
planes, and including direct oxygen hopping matrix elements, we have been able
to derive the effective t-J Hamiltonian for the copper orbitals using the
Linked Cluster Expansion Method up to fourth order in the hybridization matrix
element.Comment: (ps version of the dvi file, resubmitted because previous
uucompressed version was corrupted), 9 page
Friction force on slow charges moving over supported graphene
We provide a theoretical model that describes the dielectric coupling of a 2D
layer of graphene, represented by a polarization function in the Random Phase
Approximation, and a semi-infinite 3D substrate, represented by a surface
response function in a non-local formulation. We concentrate on the role of the
dynamic response of the substrate for low-frequency excitations of the combined
graphene-substrate system, which give rise to the stopping force on slowly
moving charges above graphene. A comparison of the dielectric loss function
with experimental HREELS data for graphene on a SiC substrate is used to
estimate the damping rate in graphene and to reveal the importance of phonon
excitations in an insulating substrate. A signature of the hybridization
between graphene's pi plasmon and the substrate's phonon is found in the
stopping force. A friction coefficient that is calculated for slow charges
moving above graphene on a metallic substrate shows an interplay between the
low-energy single-particle excitations in both systems.Comment: 13 pages, 5 figures, submitted to Nanotechnology for a special issue
related to the NGC 2009 conference (http://asdn.net/ngc2009/index.shtml
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Syk-dependent Phosphorylation of CLEC-2: A Novel Mechanism of Hem-Immunoreceptor Tyrosine-Based Activation Motif Signaling
The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). In this study, we show that phosphorylation of CLEC-2 by the snake toxin rhodocytin is abolished in the absence of the tyrosine kinase Syk but is not altered in the absence of the major platelet Src family kinases, Fyn, Lyn, and Src, or the tyrosine phosphatase CD148, which regulates the basal activity of Src family kinases. Further, phosphorylation of CLEC-2 by rhodocytin is not altered in the presence of the Src family kinase inhibitor PP2, even though PLCγ2 phosphorylation and platelet activation are abolished. A similar dependence of phosphorylation of CLEC-2 on Syk is also seen in response to stimulation by an IgG mAb to CLEC-2, although interestingly CLEC-2 phosphorylation is also reduced in the absence of Lyn. These results provide the first definitive evidence that Syk mediates phosphorylation of the CLEC-2 hemITAM receptor with Src family kinases playing a critical role further downstream through the regulation of Syk and other effector proteins, providing a new paradigm in signaling by YXXL-containing receptors
Power supply of autonomous systems using solar modules
The article shows the methods of constructing autonomous decentralized energy systems from solar modules. It shows the operation of up DC inverter. It demonstrates the effectiveness of DC inverters with varying structure. The system has high efficiency and low level of conductive impulse noise and at the same time the system is practically feasible. Electrical processes have been analyzed to determine the characteristics of operating modes of the main circuit elements. Recommendations on using the converters have been given
Accurate quantification of selenoproteins in human plasma/serum by isotope dilution ICP-MS : focus on selenoprotein P
Acknowledgements The research leading to these results was funded by the EMRP Joint Research Project “Metrology for metalloproteins” (HLT-05 2012). The EMRP is jointly funded by the EMRP participating countries within EURAMET and the European Union.Peer reviewedPostprin
Neutral description and exchange of design computational workflows
Proposed in this paper is a neutral representation of design computational workflows which allows
their exchange and sharing between different project partners and across design stages. This is
achieved by the de-coupling of configuration and execution logic. Thus, the same underlying
workflow can be executed with different (fidelity) models and different software tools as long as the
inputs and outputs of the constituent process are kept the same. To this purpose, an object model is
proposed to define different simulation objects, their scope, and hierarchy in the simulation process.
An XML based computer readable representation of workflows based on the proposed object model, is
also suggested. The application of the proposed representation is demonstrated via a case study
involving the exchange of workflows between two design partners. The case study also demonstrates
how the same workflow can be executed using different execution tools and involving different
fidelity models
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