66 research outputs found
Genetics ignite focus on microglial inflammation in Alzheimer’s disease
In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD
Correlations vs connectivity in R-charge
The holographic relation between quantum correlations and connectivity of
spacetime is explored for single R-charged AdS black holes and their
half-BPS limits (superstars). In a two boundary set-up, the wormhole between
both universes reduces to a designable and computable quantum mechanical
correlation between the dual microscopic degrees of freedom in the BPS limit.
This quantum connectivity is seen as a naked singularity by a single sided
observer. In a single boundary set-up, as a small step towards the description
of entangled black holes, we describe quantum teleportation between two labs in
different locations of the transverse 5-sphere using entangled gravitons in a
reference state that provides a classical channel between both labs.Comment: 53 pages + appendices, 29 figures v2: few corrections and added a
conclusion sectio
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