The effects of interstimulus interval on sensory gating and on preattentive auditory memory in the oddball paradigm. Can magnitude of the sensory gating affect preattentive auditory comparison process?

İstanbul Bilim Üniversitesi, Tıp Fakültesi.P50, and mismatch negativity (MMN) are components of event-related potentials (ERP) reflecting sensory gating and preattentive auditory memory, respectively. Interstimulus interval (ISI) is an important determinant of the amplitudes of these components and N1. In the present study the interrelation between stimulus gating and preattentive auditory sensory memory were investigated as a function of ISI in 1.5, 2.5 and 3.5 s in 15 healthy volunteered participants. ISI factor affected the N1 peak amplitude significantly. MMN amplitude in 2.5 s ISI was significantly smaller compared to 1.5 and 3.5 s ISI. ISI X stimuli interaction on P50 amplitude was statistically significant. P50 amplitudes to deviant stimuli in 2.5 s ISI were larger than the P50 amplitudes in other ISIs. P50 difference (P50d) waveform amplitude correlated significantly with MMN amplitude. The results suggest that: (i) auditory sensory gating could affect preattentive auditory sensory memory by supplying input to the comparator mechanism; (ii) 2.5 s ISI is important in displaying the sensory gating and preattentive auditory sensory memory relation

Event-related potentials during auditory oddball, and combined auditory oddball-visual paradigms.

İstanbul Bilim Üniversitesi, Tıp Fakültesi.The purpose of the current study was to investigate the properties of a new modification of the classical auditory oddball paradigm (auditory oddballparadigm combined with passive visual stimulation, AERPs + VEPs) and compare the scalp topography obtained with the new paradigm and the classical auditory oddball paradigm (AERPs) in healthy humans. The responses to bimodal stimulation, and to the classical oddball paradigm were similar to those reported in other studies in terms of location, amplitudes, and latencies of P1, N1, P2, N2, and P300. The new modification of theoddball paradigm produced P300 at fronto-central locations in contrast to centro-parietal locations during the classical oddball paradigm. The amplitudes and latencies of P300 were also significantly larger during the new than the classical paradigm. Furthermore, the amplitudes of N1 and P2, but not N2 were significantly higher and differed in location during the new paradigm in response to both target and standard stimuli. The latencies of all three waves were significantly longer and the latency of P2 differed in location between the new and the classical paradigms in response to only the standard stimuli. The results of this study suggest that the new modification of the classical oddball paradigm produces different neural responses to the classical oddball paradigm. Therefore, this modification can be used to investigate dysfunctions in sensory and cognitive processing in clinical samples

Event related potentials to mental arithmetic during cold stress

İstanbul Bilim Üniversitesi, Tıp Fakültesi.AMAÇ: Tek başına ve soğuk stres (SS) sırasında Zihinsel aritmetik hesaplamanın (ZA) Go/NoGo paradigması kullanılarak olaya ilişkin beyin potansiyelleri bağlamında incelenmesi. GEREÇ ve YÖNTEM: Gönüllü üniversite öğrencisi 7 deneğin 11 kanaldan EEG kaydı yapıldı. Deneklerin işlem yapmadıkları, soğuk stres altında oldukları, aritmetik işlem yaptıkları ve soğuk stres sırasında aritmetik işlem yaptıkları durumlarda kan basınçları ve kalp atımları ölçüldü. EEG kayıtlar ZA ve ZA +SS koşullarında Go/NoGO paradigması sırasında alındı. Deneklere ekranda 400 ms süre ile aritmetik bir işlem ve bundan 700 ms sonra sonuç gösterildi. Deneklerden, gösterilen sonuç doğru ise düğmeye basmaları yanlış ise basmamaları istendi

Neurofeedback intervention in fibromyalgia syndrome; a randomized, controlled, rater blind clinical trial.

İstanbul Bilim Üniversitesi, Tıp Fakültesi.We designed a randomized, rater blind study to assess the efficacy of EEG Biofeedback (Neurofeedback-NFB) in patients with fibromyalgia syndrome (FMS). Eighteen patients received twenty sessions of NFB-sensory motor rhythm (SMR) treatment (NFB group) during 4 weeks, and eighteen patients were given 10 mg per day escitalopram treatment (control group) for 8 weeks. Visual Analog Scales for pain and fatigue, Hamilton and Beck Depression and Anxiety Inventory Scales, Fibromyalgia Impact Questionnaire and Short Form 36 were used as outcome measures which were applied at baseline and 2nd, 4th, 8th, 16th, 24th weeks. Mean amplitudes of EEG rhythms (delta, theta, alpha, SMR, beta1 and beta2) and theta/SMR ratio were also measured in NFB group. All post-treatment measurements showed significant improvements in both of the groups (for all parameters p 0.05 for all). However, theta/SMR ratio showed a significant decrease at 4th week compared to baseline in the NFB group (p < 0.05). These data support the efficacy of NFB as a treatment for pain, psychological symptoms and impaired quality of life associated with fibromyalgia

Neurofeedback in fibromyalgia syndrome

İstanbul Bilim Üniversitesi, Tıp Fakültesi.EEG Biofeedback (Neurofeedback-NFB) is a learning strategy that enables people to alter their brainwaves. In the present case study, we applied a NFB protocol on three patients with Fibromyalgia Syndrome (FMS). The existing symptoms and clinical conditions of the patients attributed to FMS, Visual Analog Scale for pain and fatigue, Hamilton Depression and Anxiety Inventory Scales, Beck Depression and Anxiety Inventory Scales, and SF-36 were recorded before and after NFB training. Most of the symptoms were decreased after ten sessions. There was also improvement in all of the scales after the treatment. The results of the present study may suggest NFB training as a novel treatment method in FMS.EEGbiyofeedback (Nörofeedback-NFB), kişilerin beyin dalgalarını değiştirebilmelerini sağlayan bir öğrenme stratejisidir. Bu olgu sunumunda, Fibromyalji Sendromu (FMS) bulunan üç hastaya NFB protokolü uyguladık. Vizüel Analog Skala ile ağrı değerlendirmesi, yorgunluk, Hamilton Depresyon ve Anksiyete Çizelgesi Ölçeği, Back Depresyon ve Anksiyete Çizelgesi Ölçeği ve SF-36 kayıtları, NFB uygulaması öncesinde ve sonrasında değerlendirildi. On seans sonunda semptomların çoğu azaldı. Ölçeklerin tümünde tedavi sonrası ilerleme kaydedildi. Bu çalışmanın sonuçları, NFB uygulamasına FMS tedavisinde yeni bir metot olabileceğini düşündürmektedir

Event-related potentials to visual, auditory, and bimodal (combined auditory-visual) stimuli.

İstanbul Bilim Üniversitesi, Tıp Fakültesi.The purpose of this study was to investigate the response properties of event related potentials to unimodal and bimodal stimulations. The amplitudes of N1 and P2 were larger during bimodal evoked potentials (BEPs) than auditory evoked potentials (AEPs) in the anterior sites and the amplitudes of P1 were larger during BEPs than VEPs especially at the parieto-occipital locations. Responses to bimodal stimulation had longer latencies than responses to unimodal stimulation. The N1 and P2 components were larger in amplitude and longer in latency during the bimodal paradigm and predominantly occurred at the anterior sites. Therefore, the current bimodal paradigm can be used to investigate the involvement and location of specific neural generators that contribute to higher processing of sensory information. Moreover, this paradigm may be a useful tool to investigate the level of sensory dysfunctions in clinical samples