Correction: HLA Class I and Class II Associations with ESRD in Saudi Arabian Population.

[This corrects the article DOI: 10.1371/journal.pone.0111403.]

HLA class I and class II associations with ESRD in Saudi Arabian population.

Chronic renal failure (CRF) leads in the majority of instances to end stage renal disease (ESRD) requiring renal replacement therapy. Our interest was to evaluate the possible associations of HLA class I and class II antigens with ESRD independent of other factors, in Saudi Arabia population.A retrospective study to determine the HLA class I and class II polymorphisms and their association with ESRD, was performed on 350 patients with ESRD, and 105 healthy unrelated control. Patients and control groups were typed by SSOP lumenix techniques. The alleles positively associated to the ESRD were: HLA-B*15, B*18, B*49 - DRB1*03, negatively associated alleles were A*26, HLA-B*39, B*50. The haplotypes positively associated with ESRD were: HLA-A*01-DRB1*13 and HLA-A*30-DRBI*03. The negatively associated haplotypes were: HLA-A*02-B*39, A*02-B*50, A*24-B*35, A*24-B*58, A*24-DRB1*16, A*68-DRB1*04, A*02-DQB1*03, A*29-DQB1*02, A*29-DOB1*05 and B*27-DRB1*07 and the last one is the most significant protective haplotypes.The high Relative Risk (RR) observed and its statistical correlation reflect the strength of the described association between HLA antigens and ESRD

Characteristic of ESRD cases and controls for age and sex.

<p>Characteristic of ESRD cases and controls for age and sex.</p

The frequency and associations of HLA B* alleles in ESRD patients and healthy controls.

<p>N =  number of individuals, ESRD  =  End Stage Renal Disease, control  =  healthy donors, F =  alleles frequency, p =  Fisher's exact p value, RR =  Relative Risk.</p><p>The frequency and associations of HLA B* alleles in ESRD patients and healthy controls.</p

The frequency and associations of HLA DRB1 alleles in ESRD patients and healthy controls.

<p>N =  number of individuals, ESRD  =  End Stage Renal Disease, control  =  healthy donors, F =  alleles frequency, p =  Fisher's exact p value, RR =  Relative Risk.</p><p>The frequency and associations of HLA DRB1 alleles in ESRD patients and healthy controls.</p

Main high-frequency HLA B– DRB1 haplotype and their frequencies in ESRD patients and healthy controls (haplotype frequency ≥1.5%).

<p>Main high-frequency HLA B– DRB1 haplotype and their frequencies in ESRD patients and healthy controls (haplotype frequency ≥1.5%).</p

The frequency and associations of HLA DQB1 alleles in ESRD patients and healthy controls.

<p>N =  number of individuals, ESRD  =  End Stage Renal Disease, control  =  healthy donors, F =  alleles frequency, p =  Fisher's exact p value, RR =  Relative Risk.</p><p>The frequency and associations of HLA DQB1 alleles in ESRD patients and healthy controls.</p

Main high-frequency HLA A – DRB1 haplotype and their frequencies in ESRD patients and healthy controls (haplotype frequency ≥1.5%).

<p>Main high-frequency HLA A – DRB1 haplotype and their frequencies in ESRD patients and healthy controls (haplotype frequency ≥1.5%).</p