20 research outputs found
Risk factors for fatality of confirmed cases of Ebola virus disease, Liberia, April 4, 2014–March 29, 2015 (n = 3,897).
<p>Risk factors for fatality of confirmed cases of Ebola virus disease, Liberia, April 4, 2014–March 29, 2015 (n = 3,897).</p
Flowchart showing processing of patient data collected by laboratories during the Ebola virus disease outbreak, Liberia, April 4, 2014–March 29, 2015.
<p>EBOV: Ebola virus. The chart shows the data processing procedure and number of cases identified. (a) Includes indeterminate results, test failures, and tests not performed due to reasons such as insufficient volume or low sample quality. (b) Comprises suspected and probable cases, because the data did not enable us to distinguish between suspected and probable cases. <sup>c</sup> Patient status refers to the patient being dead or alive at the time of sample collection.</p
Trimonthly case fatality rate of confirmed cases of Ebola virus disease outbreak, Liberia, April 4, 2014–March 29, 2015 (n = 3,897).
<p>The p-value, calculated using the Mantel–Haenszel test for trend, was <0.001. Error bars indicate 95% confidence interval.</p
Profiles of confirmed cases of Ebola virus disease and Ebola viral RNA-negative suspected cases, Liberia, April 4, 2014–March 29, 2015 (n = 7,872).
<p>Profiles of confirmed cases of Ebola virus disease and Ebola viral RNA-negative suspected cases, Liberia, April 4, 2014–March 29, 2015 (n = 7,872).</p
Challenges encountered during the pandemic response in Yemen Challenges.
Challenges encountered during the pandemic response in Yemen Challenges.</p
Timelines highlighting important milestones on the evolution of virus in Yemen and period for the establishment of PCR and other laboratories.
Timelines highlighting important milestones on the evolution of virus in Yemen and period for the establishment of PCR and other laboratories.</p
Improvement in the molecular biology capacity in Yemen—Before and after the COVID-19 pandemic.
Improvement in the molecular biology capacity in Yemen—Before and after the COVID-19 pandemic.</p
S1 Dataset -
BackgroundWhen the COVID-19 pandemic was declared, Yemen, a country facing years of conflict had only one laboratory with PCR testing capacity. In this article, we describe the outcome of the implementation of molecular based diagnostics platform in Yemen and highlight the key milestones the country went through to increase access to testing for its populations residing in a geographically vast and politically divided country.MethodsA retrospective assessment of COVID-19 laboratory response activities was done detailing the needs assessment process, timelines, geographical coverage, and outcomes of the activities. Laboratory data was analyzed to construct the geographical locations of COVID-19 testing laboratories and the numbers of tests performed in each facility to highlight the demands of testing for travelers. Finally, we discuss the impact these activities had in enabling the movement of people across international borders for economic gains and in delivery of critical humanitarian aid.OutcomePCR testing capacities in Yemen significantly improved, from one laboratory in Sanaa in April 2020 to 18 facilities across the country by June 2022. In addition, the number of functional Real-Time PCR thermocyclers increased from one to 32, the PCR tests output per day improved from 192 to 6144 tests per day. Results from analysis of laboratory data showed there were four peaks of COVID-19 in Yemen as October 2022. The majority of laboratory tests were performed for travelers than for medical or public health reasons. Demand for laboratory testing in Yemen was generally low and waned over time as the perceived risk of COVID-19 declined, in parallel with rollout of the COVID-19 vaccines.Discussion/ConclusionThe successful expansion of laboratory testing capacity was instrumental in the control and management of COVID-19 cases and critical in the implementation of public response strategies, including restrictions on gathering. Laboratory testing also facilitated the movement of humanitarian agencies and delivery of aid and enabled hundreds of thousands of Yemeni nationals to travel internationally. By virtue of these outcomes, the impact of laboratory strengthening activities was thus felt in the health sector and beyond.</div
Temporal patterns of SARS-COV-2 samples analyzed for the purposes of surveillance in Yemen from April 2020 to December 2022.
Temporal patterns of SARS-COV-2 samples analyzed for the purposes of surveillance in Yemen from April 2020 to December 2022.</p
Performance of two national-level laboratories in external quality assessment scheme.
Performance of two national-level laboratories in external quality assessment scheme.</p