801 research outputs found
Biomolecular imaging and electronic damage using X-ray free-electron lasers
Proposals to determine biomolecular structures from diffraction experiments
using femtosecond X-ray free-electron laser (XFEL) pulses involve a conflict
between the incident brightness required to achieve diffraction-limited atomic
resolution and the electronic and structural damage induced by the
illumination. Here we show that previous estimates of the conditions under
which biomolecular structures may be obtained in this manner are unduly
restrictive, because they are based on a coherent diffraction model that is not
appropriate to the proposed interaction conditions. A more detailed imaging
model derived from optical coherence theory and quantum electrodynamics is
shown to be far more tolerant of electronic damage. The nuclear density is
employed as the principal descriptor of molecular structure. The foundations of
the approach may also be used to characterize electrodynamical processes by
performing scattering experiments on complex molecules of known structure.Comment: 16 pages, 2 figure
Comparison and relative utility of inequality measurements: as applied to Scotland’s child dental health
This study compared and assessed the utility of tests of inequality on a series of very large population caries datasets. National cross-sectional caries datasets for Scotland’s 5-year-olds in 1993/94 (n = 5,078); 1995/96 (n = 6,240); 1997/98 (n = 6,584); 1999/00 (n = 6,781); 2002/03 (n = 9,747); 2003/04 (n = 10,956); 2005/06 (n = 10,945) and 2007/08 (n = 12,067) were obtained. Outcomes were based on the d3mft metric (i.e. the number of decayed, missing and filled teeth). An area-based deprivation category (DepCat) measured the subjects’ socioeconomic status (SES). Simple absolute and relative inequality, Odds Ratios and the Significant Caries Index (SIC) as advocated by the World Health Organization were calculated. The measures of complex inequality applied to data were: the Slope Index of Inequality (absolute) and a variety of relative inequality tests i.e. Gini coefficient; Relative Index of Inequality; concentration curve; Koolman and Doorslaer’s transformed Concentration Index; Receiver Operator Curve and Population Attributable Risk (PAR). Additional tests used were plots of SIC deciles (SIC10) and a Scottish Caries Inequality Metric (SCIM10). Over the period, mean d3mft improved from 3.1(95%CI 3.0–3.2) to 1.9(95%CI 1.8–1.9) and d3mft = 0% from 41.1(95%CI 39.8–42.3) to 58.3(95%CI 57.8–59.7). Absolute simple and complex inequality decreased. Relative simple and complex inequality remained comparatively stable. Our results support the use of the SII and RII to measure complex absolute and relative SES inequalities alongside additional tests of complex relative inequality such as PAR and Koolman and Doorslaer’s transformed CI. The latter two have clear interpretations which may influence policy makers. Specialised dental metrics (i.e. SIC, SIC10 and SCIM10) permit the exploration of other important inequalities not determined by SES, and could be applied to many other types of disease where ranking of morbidity is possible e.g. obesity. More generally, the approaches described may be applied to study patterns of health inequality affecting worldwide populations
Hydrogen-poor superluminous stellar explosions
Supernovae (SNe) are stellar explosions driven by gravitational or
thermonuclear energy, observed as electromagnetic radiation emitted over weeks
or more. In all known SNe, this radiation comes from internal energy deposited
in the outflowing ejecta by either radioactive decay of freshly-synthesized
elements (typically 56Ni), stored heat deposited by the explosion shock in the
envelope of a supergiant star, or interaction between the SN debris and
slowly-moving, hydrogen-rich circumstellar material. Here we report on a new
class of luminous SNe whose observed properties cannot be explained by any of
these known processes. These include four new SNe we have discovered, and two
previously unexplained events (SN 2005ap; SCP 06F6) that we can now identify as
members. These SNe are all ~10 times brighter than SNe Ia, do not show any
trace of hydrogen, emit significant ultra-violet (UV) flux for extended periods
of time, and have late-time decay rates which are inconsistent with
radioactivity. Our data require that the observed radiation is emitted by
hydrogen-free material distributed over a large radius (~10^15 cm) and
expanding at high velocities (>10^4 km s^-1). These long-lived, UV-luminous
events can be observed out to redshifts z>4 and offer an excellent opportunity
to study star formation in, and the interstellar medium of, primitive distant
galaxies.Comment: Accepted to Nature. Press embargoed until 2011 June 8, 18:00 U
The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement
Abnormalities of motivation and behavior in the context of reward are a fundamental component of addiction and mood disorders. Here we test the effect of a functional missense mutation in the dopamine 3 receptor (DRD3) gene (ser9gly, rs6280) on reward-associated dopamine (DA) release in the striatum. Twenty-six healthy controls (HCs) and 10 unmedicated subjects with major depressive disorder (MDD) completed two positron emission tomography (PET) scans with [11C]raclopride using the bolus plus constant infusion method. On one occasion subjects completed a sensorimotor task (control condition) and on another occasion subjects completed a gambling task (reward condition). A linear regression analysis controlling for age, sex, diagnosis, and self-reported anhedonia indicated that during receipt of unpredictable monetary reward the glycine allele was associated with a greater reduction in D2/3 receptor binding (i.e., increased reward-related DA release) in the middle (anterior) caudate (p<0.01) and the ventral striatum (p<0.05). The possible functional effect of the ser9gly polymorphism on DA release is consistent with previous work demonstrating that the glycine allele yields D3 autoreceptors that have a higher affinity for DA and display more robust intracellular signaling. Preclinical evidence indicates that chronic stress and aversive stimulation induce activation of the DA system, raising the possibility that the glycine allele, by virtue of its facilitatory effect on striatal DA release, increases susceptibility to hyperdopaminergic responses that have previously been associated with stress, addiction, and psychosis
Constraining dust and color variations of high-z SNe using NICMOS on Hubble Space Telescope
We present data from the Supernova Cosmology Project for five high redshift
Type Ia supernovae (SNe Ia) that were obtained using the NICMOS infrared camera
on the Hubble Space Telescope. We add two SNe from this sample to a rest-frame
I-band Hubble diagram, doubling the number of high redshift supernovae on this
diagram. This I-band Hubble diagram is consistent with a flat universe
(Omega_Matter, Omega_Lambda= 0.29, 0.71). A homogeneous distribution of large
grain dust in the intergalactic medium (replenishing dust) is incompatible with
the data and is excluded at the 5 sigma confidence level, if the SN host galaxy
reddening is corrected assuming R_V=1.75. We use both optical and infrared
observations to compare photometric properties of distant SNe Ia with those of
nearby objects. We find generally good agreement with the expected color
evolution for all SNe except the highest redshift SN in our sample (SN 1997ek
at z=0.863) which shows a peculiar color behavior. We also present spectra
obtained from ground based telescopes for type identification and determination
of redshift.Comment: 30 pages, 10 figures; accepted for publication in ApJ; v2: revised to
match the version in the journa
Type Ia Supernovae as Stellar Endpoints and Cosmological Tools
Empirically, Type Ia supernovae are the most useful, precise, and mature
tools for determining astronomical distances. Acting as calibrated candles they
revealed the presence of dark energy and are being used to measure its
properties. However, the nature of the SN Ia explosion, and the progenitors
involved, have remained elusive, even after seven decades of research. But now
new large surveys are bringing about a paradigm shift --- we can finally
compare samples of hundreds of supernovae to isolate critical variables. As a
result of this, and advances in modeling, breakthroughs in understanding all
aspects of SNe Ia are finally starting to happen.Comment: Invited review for Nature Communications. Final published version.
Shortened, update
Observational and Physical Classification of Supernovae
This chapter describes the current classification scheme of supernovae (SNe).
This scheme has evolved over many decades and now includes numerous SN Types
and sub-types. Many of these are universally recognized, while there are
controversies regarding the definitions, membership and even the names of some
sub-classes; we will try to review here the commonly-used nomenclature, noting
the main variants when possible. SN Types are defined according to
observational properties; mostly visible-light spectra near maximum light, as
well as according to their photometric properties. However, a long-term goal of
SN classification is to associate observationally-defined classes with specific
physical explosive phenomena. We show here that this aspiration is now finally
coming to fruition, and we establish the SN classification scheme upon direct
observational evidence connecting SN groups with specific progenitor stars.
Observationally, the broad class of Type II SNe contains objects showing strong
spectroscopic signatures of hydrogen, while objects lacking such signatures are
of Type I, which is further divided to numerous subclasses. Recently a class of
super-luminous SNe (SLSNe, typically 10 times more luminous than standard
events) has been identified, and it is discussed. We end this chapter by
briefly describing a proposed alternative classification scheme that is
inspired by the stellar classification system. This system presents our
emerging physical understanding of SN explosions, while clearly separating
robust observational properties from physical inferences that can be debated.
This new system is quantitative, and naturally deals with events distributed
along a continuum, rather than being strictly divided into discrete classes.
Thus, it may be more suitable to the coming era where SN numbers will quickly
expand from a few thousands to millions of events.Comment: Extended final draft of a chapter in the "SN Handbook". Comments most
welcom
Research on health transition in Africa: time for action
With rapidly increasing globalization, trends towards unhealthy diets, obesity, sedentary lifestyles and unhealthy habits are resulting in an increased worldwide burden of chronic non-communicable diseases (NCDs). In Africa this means that health systems face the challenge of an increasing burden of NCDs and of continuing high morbidity and mortality from communicable diseases. This health transition represents an enormous challenge to Africa as the region with the least resources for an effective response. Whereas previous epidemics, including HIV, have caught Africa unprepared, the opportunity now arises to take the advancing wave of health transition in Africa seriously. Health research has a key role to play in meeting health and development goals, and must be responsive to changing disease patterns, such as health transition. There is an urgent need for research on health transition in Africa to enable countries to respond effectively to rapidly changing health needs
Cohesive forces prevent the rotational breakup of rubble-pile asteroid (29075) 1950 DA
Space missions and ground-based observations have shown that some asteroids are loose collections of rubble rather than solid bodies. The physical behaviour of such ‘rubble-pile’ asteroids has been traditionally described using only gravitational and frictional forces within a granular material. Cohesive forces in the form of small van der Waals forces between constituent grains have recently been predicted to be important for small rubble piles (ten kilometres across or less), and could potentially explain fast rotation rates in the small-asteroid population. The strongest evidence so far has come from an analysis of the rotational breakup of the main-belt comet P/2013 R3, although that was indirect and poorly constrained by observations. Here we report that the kilometre-sized asteroid (29075) 1950 DA is a rubble pile that is rotating faster than is allowed by gravity and friction. We find that cohesive forces are required to prevent surface mass shedding and structural failure, and that the strengths of the forces are comparable to, though somewhat less than, the forces found between the grains of lunar regolith
The Evolution of Compact Binary Star Systems
We review the formation and evolution of compact binary stars consisting of
white dwarfs (WDs), neutron stars (NSs), and black holes (BHs). Binary NSs and
BHs are thought to be the primary astrophysical sources of gravitational waves
(GWs) within the frequency band of ground-based detectors, while compact
binaries of WDs are important sources of GWs at lower frequencies to be covered
by space interferometers (LISA). Major uncertainties in the current
understanding of properties of NSs and BHs most relevant to the GW studies are
discussed, including the treatment of the natal kicks which compact stellar
remnants acquire during the core collapse of massive stars and the common
envelope phase of binary evolution. We discuss the coalescence rates of binary
NSs and BHs and prospects for their detections, the formation and evolution of
binary WDs and their observational manifestations. Special attention is given
to AM CVn-stars -- compact binaries in which the Roche lobe is filled by
another WD or a low-mass partially degenerate helium-star, as these stars are
thought to be the best LISA verification binary GW sources.Comment: 105 pages, 18 figure
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