Obscuring fraction of active galactic nuclei implied by supernova and radiative feedbacks

We study the obscuring structure of circumnuclear disks (CNDs) by considering supernova (SN) feedbacks from nuclear starburst and the effect of anisotropic radiative pressure from AGNs. We suppose that the mass accretion onto a central supermassive black hole (SMBH) is triggered by SN-driven turbulence within CNDs, and we explore how the structures of CNDs depend on the BH mass ($M_{\rm BH}$) and AGN luminosity ($L_{\rm AGN}$). We find that the obscuring fraction ($f_{\rm obs}$) peaks at $\sim10\%$ of the Eddington luminosity ($L_{\rm Edd}$), and its maximal value is $f_\mathrm{obs} \sim 0.6$ for less massive SMBHs (e.g., $M_{\rm BH} < 10^{8}M_{\odot}$). This is because the scale height of CNDs is determined by the SN-driven accretion for a smaller $L_{\rm AGN}$, while the dusty molecular gas in CNDs is blown away by the radiation pressure from AGNs beyond the critical luminosity. On the other hand, for massive SMBHs (e.g., $M_{\rm BH} > 10^{8}M_{\odot}$), $f_{\rm obs}$ is always smaller than $0.2$, and it is almost independent of $L_{\rm AGN}$ because the scale height of CNDs is mainly controlled by the maximal star-formation efficiency ($C_{\rm *, max}$) in CNDs. By comparison with the obscuring fractions suggested from the mid-infrared observations of nearby AGNs, the SN plus radiative feedback model with $C_{\rm *, max} = 10^{-7}\, {\rm yr}^{-1}$ well reproduces the observations for $M_\mathrm{BH} = 10^8 M_\odot$. We also find that the intense starburst or the existence of dust-free absorbers inside CNDs are necessary, to explain X-ray observations.Comment: 17 pages, 11 figures, Accepted for publication in Ap

Growth of Intermediate Massive Black Holes in the Hierarchical Formation of Small Spiral Galaxies in the High-z Universe

Combining a theoretical model of mass accretion onto a galactic center with a high-resolution $N$-body/SPH simulation, we investigate the formation of an intermediate massive black hole (IMBH) during the hierarchical formation of a small spiral galaxy (with a total mass of $10^{10}M_{\odot}$) in the high-$z$ universe. We found that the rate of average mass accretion to the nucleus due to the radiation drag exerted by newly formed stars in the forming galaxy is $\approx 10^{-5}M_{\odot}$yr$^{-1}$. As a result of this accretion, an IMBH with $\approx 10^{4}M_{\odot}$ can be formed in the center of the spiral galaxy at $z\sim 4$. We found that a central BH coevolves with the dark matter halo from $z\sim 15$ to $z\sim 2$. The mass ratio of the BH to the dark matter halo is nearly constant $\approx (1-3) \times 10^{-6}$ from $z\sim 10$ to $z\sim 2$. This is because that change in the dark matter potential enhances star formation in the central part of the galaxy, and as a result the BH evolves due to mass accretion via the radiation drag. Therefore, our model naturally predicts a correlation between massive BHs and dark matter halos. Moreover, it is found that the final BH-to-bulge mass ratio ($\approx 5\times 10^{-5}$) in a small spiral galaxy at high-$z$ is much smaller than that in the large galaxies ($\approx 10^{-3}$). Our results also suggest that the scatter in the observed scaling relations between the bulge mass and black hole mass are caused by a time lag between BH growth and growth of bulge. We also predict that the X-ray luminosity of AGN is positively correlated with the CO luminosity in the central region. By comparing our results with the properties of Lyman break galaxies (LBGs), it is predicted that some LBGs have massive BHs of $\approx 10^{6}-10^{7}M_{\odot}$.Comment: 8pages, 7figures, accepted for publication in ApJ (Volume 628, 20 July 2005 issue

Multiphase Gas Nature in the Sub-parsec Region of the Active Galactic Nuclei I: Dynamical Structures of Dusty and Dust-free Outflow

We investigated dusty and dust-free gas dynamics for a radiation-driven sub-pc scale outflow in an active galactic nucleus (AGN) associated with a supermassive black hole $10^7 M_\odot$ and bolometric luminosity $10^{44}$ erg s$^{-1}$ based on the two-dimensional radiation-hydrodynamic simulations. A radiation-driven ``lotus-like'' multi-shell outflow is launched from the inner part ($r \lesssim 0.04$ pc) of the geometrically thin disk, and it repeatedly and steadily produces shocks as mass accretion continues through the disk to the center. The shape of the dust sublimation radius is not spherical and depends on the angle ($\theta$) from the disk plane, reflecting the non-spherical radiation field and nonuniform dust-free gas. Moreover, we found that the sublimation radius of $\theta \sim 20$-$60$ deg varies on a timescale of several years. The ``inflow-induced outflow" contributes the obscuration of the nucleus in the sub-parsec region. The column density of the dust-free gas is $N_{\rm H} \gtrsim 10^{22}$ cm$^{-2}$ for $r \lesssim 0.04$ pc. Gases near the disk plane ($\theta \lesssim 30$ degree) can be the origin of the Compton-thick component, which was suggested by the recent X-ray observations of AGNs. The dusty outflow from the sub-parsec region can be also a source of material for the radiation-driven fountain for a larger scale.Comment: 13 pages, 9 figures, accepted for publication in Ap

Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma

Chronic viral hepatitis B and C and non-alcoholic fatty liver disease (NAFLD) have been widely acknowledged to be the leading causes of liver cirrhosis and hepatocellular carcinoma. As anti-viral treatment progresses, the impact of NAFLD is increasing. NAFLD can coexist with chronic viral hepatitis and exacerbate its progression. Oxidative stress has been recognized as a chronic liver disease progression-related and cancer-initiating stress response. However, there are still many unresolved issues concerning oxidative stress, such as the correlation between the natural history of the disease and promising treatment protocols. Recent findings indicate that oxidative stress is also an anti-cancer response that is necessary to kill cancer cells. Oxidative stress might therefore be a cancer-initiating response that should be down regulated in the pre-cancerous stage in patients with risk factors for cancer, while it is an anti-cancer cell response that should not be down regulated in the post-cancerous stage, especially in patients using anti-cancer agents. Antioxidant nutrients should be administered carefully according to the patients' disease status. In this review, we will highlight these paradoxical effects of oxidative stress in chronic liver diseases, pre- and post-carcinogenesis

Coevolution of Supermassive Black Holes and Circumnuclear Disks

We propose a new evolutionary model of a supermassive black hole (SMBH) and a circumnuclear disk (CND), taking into account the mass-supply from a host galaxy and the physical states of CND. In the model, two distinct accretion modes depending on gravitational stability of the CND play a key role on accreting gas to a SMBH. (i) If the CMD is gravitationally unstable, energy feedback from supernovae (SNe) supports a geometrically thick, turbulent gas disk. The accretion in this mode is dominated by turbulent viscosity, and it is significantly larger than that in the mode (ii), i.e., the CMD is supported by gas pressure. Once the gas supply from the host is stopped, the high accretion phase ($\sim 0.01- 0.1 M_{\odot} {\rm yr}^{-1}$) changes to the low one (mode (ii), $\sim 10^{-4} M_{\odot} {\rm yr}^{-1}$), but there is a delay with $\sim 10^{8}$ yr. Through this evolution, the gas-rich CND turns into the gas poor stellar disk. We found that not all the gas supplied from the host galaxy accrete onto the SMBH even in the high accretion phase (mode (i)), because the part of gas is used to form stars. As a result, the final SMBH mass ($M_{\rm BH,final}$) is not proportional to the total gas mass supplied from the host galaxy ($M_{\rm sup}$); $M_{\rm BH,final}/M_{\rm sup}$ decreases with $M_{\rm sup}$.This would indicate that it is difficult to form a SMBH with $\sim 10^{9} M_{\odot}$ observed at high-$z$ QSOs. The evolution of the SMBH and CND would be related to the evolutionary tracks of different type of AGNs.Comment: 11 pages, 11 figures, accepted for publication in Ap

Liver Sarcoidosis with Unique MRI Images Using Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid

Sarcoidosis is a systemic disease characterized by the formation of non-caseating granulomas in multiple organs. In the diagnosis of sarcoidosis, imaging modalities such as ultrasonography, computed tomography (CT) and magnetic resonance imaging (MRI) are useful;however, there are few reports of MRI imaging using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB) MRI. A 46-year-old Japanese female with suspected pulmonary sarcoidosis was admitted to our hospital because low-density mottles in the liver were observed incidentally by chest CT. The low-density mottles were not enhanced at the arterial phase or portal phase by abdominal CT and MRI, and decreased uptake was observed in the hepatobiliary phase of Gd-EOB MRI. No hematological disorder was observed except for a slight increase of biliary enzymes. The lesion was diagnosed as liver sarcoidosis by the liver biopsy. Since the patient refused steroid therapy, we prescribed ursodeoxycholic acid (UDCA). 600mg/day. The serum levels of biliary enzymes were normalized and the abdominal CT findings gradually improved after the initiation of UDCA medication. Gd-EOB MRI showed unique hypointense areas in the liver at the hepatobiliary phase, which might be useful in the diagnosis of liver sarcoidosis

Management of Cirrhotic Ascites under the Add-on Administration of Tolvaptan

Tolvaptan is a recently available diuretic that blocks arginine vasopressin receptor 2 in the renal collecting duct. Its diuretic mechanism involves selective water reabsorption by affecting the water reabsorption receptor aquaporin 2. Given that liver cirrhosis patients exhibit hyponatremia due to their pseudo-aldosteronism and usage of natriuretic agents, a sodium maintaining agent, such as tolvaptan, is physiologically preferable. However, large scale studies indicating the patients for whom this would be effective and describing management under its use have been insufficient. The appropriate management of cirrhosis patients treated with tolvaptan should be investigated. In the present review, we collected articles investigating the effectiveness of tolvaptan and factors associated with survival and summarized their management reports. Earlier administration of tolvaptan before increasing the doses of natriuretic agents is recommended because this may preserve effective arterial blood volume

Safety and Efficacy of Radiofrequency Ablation with Artificial Ascites for Hepatocellular Carcinoma

The artificial ascites technique is often used during radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) treatment because it prevents visceral damage and improves visualization by minimizing interference of the lungs and mesentery. This study determined the efficacy and safety of RFA using the artificial ascites technique in HCC patients. We examined 188 HCC patients who were treated by RFA and fulfilled the Milan criteria. Treatment outcomes (complete ablation rate, local recurrence rate, complication rate, liver function including total bilirubin level, alanine aminotransferase level, albumin level, and prothrombin time) were compared among patients divided into 3 groups based on the volume of artificial ascites injected:GroupⅠ (n＝86), no artificial ascites injected;GroupⅡ (n＝35), ＜1,000ml artificial ascites injected;and Group Ⅲ (n＝67), ＞1,000ml artificial ascites injected. No significant difference was observed in complete ablation or local recurrence rates among the 3 groups, or in the extent of liver function damage after RFA. Artificial ascites disappeared within 7 days; additional diuretics were needed only in 5 (all from Group Ⅲ) of 102 patients. No serious complications such as intestinal perforation or intraperitoneal bleeding were observed. Thus, we found that artificial ascites injection during RFA is effective and safe, and can be used to prevent major procedural complications