脳循環と脳脊髄液の流れを統合した動態解析モデル

Objectives:In the fluid dynamics of cerebral circulation and cerebrospinal fluid (CSF) motion, the computational simulation model has not been established. We conducted the multi-scale simulation in the cerebral circulation model. Therefore, we would like to integrate these two different fluid dynamics models.Methods & Results:Using the 3 tesla MRI and 3D workstation, the flow volumes of blood and CSF were measured in the 20 healthy volunteers. In addition, the 3D structures and movements of the brain, intracranial CSF spaces and major arteries were reconstructed for computational fluid dynamics.Conclusions:The CSF movements synchronized with a heartbeat were driven by the pulsation of large intracranial arteries and brain. In the current concepts of the cerebral circulation and fluid exchange of CSF and interstitial fluid, i.e., glymphatic system, the simulation model of the brain fluid dynamic is extremely complicated. There are many black boxes in this field