47 research outputs found
Noise Sources in Photometry and Radial Velocities
The quest for Earth-like, extrasolar planets (exoplanets), especially those
located inside the habitable zone of their host stars, requires techniques
sensitive enough to detect the faint signals produced by those planets. The
radial velocity (RV) and photometric transit methods are the most widely used
and also the most efficient methods for detecting and characterizing
exoplanets. However, presence of astrophysical "noise" makes it difficult to
detect and accurately characterize exoplanets. It is important to note that the
amplitude of such astrophysical noise is larger than both the signal of
Earth-like exoplanets and state-of-the-art instrumentation limit precision,
making this a pressing topic that needs to be addressed. In this chapter, I
present a general review of the main sources of noise in photometric and RV
observations, namely, stellar oscillations, granulation, and magnetic activity.
Moreover, for each noise source I discuss the techniques and observational
strategies which allow us to mitigate their impact.Comment: 11 pages, 2 tables, Lecture presented at the IVth Azores
International Advanced School in Space Sciences on "Asteroseismology and
Exoplanets: Listening to the Stars and Searching for New Worlds"
(arXiv:1709.00645), which took place in Horta, Azores Islands, Portugal in
July 201
Atmospheric Heating and Wind Acceleration: Results for Cool Evolved Stars based on Proposed Processes
A chromosphere is a universal attribute of stars of spectral type later than
~F5. Evolved (K and M) giants and supergiants (including the zeta Aurigae
binaries) show extended and highly turbulent chromospheres, which develop into
slow massive winds. The associated continuous mass loss has a significant
impact on stellar evolution, and thence on the chemical evolution of galaxies.
Yet despite the fundamental importance of those winds in astrophysics, the
question of their origin(s) remains unsolved. What sources heat a chromosphere?
What is the role of the chromosphere in the formation of stellar winds? This
chapter provides a review of the observational requirements and theoretical
approaches for modeling chromospheric heating and the acceleration of winds in
single cool, evolved stars and in eclipsing binary stars, including physical
models that have recently been proposed. It describes the successes that have
been achieved so far by invoking acoustic and MHD waves to provide a physical
description of plasma heating and wind acceleration, and discusses the
challenges that still remain.Comment: 46 pages, 9 figures, 1 table; modified and unedited manuscript;
accepted version to appear in: Giants of Eclipse, eds. E. Griffin and T. Ake
(Berlin: Springer
Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma.
Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., survival until death from melanoma) among patients with node-positive intermediate-thickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for patients with sentinel-node metastases is not clear.
In an international trial, we randomly assigned patients with sentinel-node metastases detected by means of standard pathological assessment or a multimarker molecular assay to immediate completion lymph-node dissection (dissection group) or nodal observation with ultrasonography (observation group). The primary end point was melanoma-specific survival. Secondary end points included disease-free survival and the cumulative rate of nonsentinel-node metastasis.
Immediate completion lymph-node dissection was not associated with increased melanoma-specific survival among 1934 patients with data that could be evaluated in an intention-to-treat analysis or among 1755 patients in the per-protocol analysis. In the per-protocol analysis, the mean (±SE) 3-year rate of melanoma-specific survival was similar in the dissection group and the observation group (86±1.3% and 86±1.2%, respectively; P=0.42 by the log-rank test) at a median follow-up of 43 months. The rate of disease-free survival was slightly higher in the dissection group than in the observation group (68±1.7% and 63±1.7%, respectively; P=0.05 by the log-rank test) at 3 years, based on an increased rate of disease control in the regional nodes at 3 years (92±1.0% vs. 77±1.5%; P<0.001 by the log-rank test); these results must be interpreted with caution. Nonsentinel-node metastases, identified in 11.5% of the patients in the dissection group, were a strong, independent prognostic factor for recurrence (hazard ratio, 1.78; P=0.005). Lymphedema was observed in 24.1% of the patients in the dissection group and in 6.3% of those in the observation group.
Immediate completion lymph-node dissection increased the rate of regional disease control and provided prognostic information but did not increase melanoma-specific survival among patients with melanoma and sentinel-node metastases. (Funded by the National Cancer Institute and others; MSLT-II ClinicalTrials.gov number, NCT00297895 .)