3 research outputs found
ΠΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠΉ ΡΠ΅Π΄ΠΎΠΊΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΠΏΠ»Π°Π·ΠΌΡ ΠΊΡΠΎΠ²ΠΈ
Aims: Determination of operating characteristics of the test based on blood plasma redox potential monitoring in patients with different pathological conditions associated with impaired oxygen metabolism during treatment in postoperative period and expanding the range of parameters of the developed method of investigation of blood plasma redox potential.Methods: It were examined healthy volunteers group as following group (n =63), groups of patients with transplanted liver (n =64), kidney (n =59), and lungs (n =7). Redox potential measurements were done by platinum electrode, reference electrode was silver-chlorine one. Potentiostate IPC-ProL was used to registrate and record a dependence redox potential via time. Time of measurement was 15 min.Results: statistically significant differencees of redox potentials ranges was found in healthy volunteers and patients with transplanted kidney and liver. Ratio of measured redox potentials coincident with the values within the confidence interval in healthy volunteers was 12% in patients with transplanted kidney and 10% in patients with transplanted liver. We observed significant differences in the nature of changes of blood plasma's redox potential values in course of monitoring of subgroups of patients with and without complications after liver transplantation. It was found that sensitivity of electrochemical method was 85%, selectivity β 69,8%, precision β 85,2%.Conclusion: we discovered value ranges of blood plasma redox potential typical for different pathological states; we detected an interaction between the effect of treatment and quantitative changes in the values of the blood plasma redox potentials; criterion for early predicition of complications in patients with transplanted liver was proposed basing on redox potential monitoring during postoperative period.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΡΠ΅ΡΡΠ° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° Π²Π΅Π»ΠΈΡΠΈΠ½ ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΠΏΠ»Π°Π·ΠΌΡ ΠΊΡΠΎΠ²ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡΠΌΠΈ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠΈΠΌΠΈΡΡ Π½Π°ΡΡΡΠ΅Π½ΠΈΡΠΌΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΡ; ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΏΠ΅ΠΊΡΡΠ° ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠ³ΠΎ Π½Π°ΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΠΏΠ»Π°Π·ΠΌΡ ΠΊΡΠΎΠ²ΠΈ.ΠΠ΅ΡΠΎΠ΄Ρ: ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ Π³ΡΡΠΏΠΏΡ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄ΠΎΠ±ΡΠΎΠ²ΠΎΠ»ΡΡΠ΅Π² (n =63) ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠΎ ΡΠ»Π΅Π΄ΡΡΡΠΈΠΌΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠΌΠΈ: Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠ΅ΠΉ ΠΏΠΎΡΠΊΠΈ (n =59), ΠΏΠ΅ΡΠ΅Π½ΠΈ (n =64) ΠΈ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ (n =7). ΠΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° ΠΏΠ»Π°ΡΠΈΠ½ΠΎΠ²ΠΎΠΌ ΠΌΠΈΠΊΡΠΎΡΠ»Π΅ΠΊΡΡΠΎΠ΄Π΅ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π½Π°ΡΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ Ρ
Π»ΠΎΡΡΠ΅ΡΠ΅Π±ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΠ΄Π° ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ. ΠΠΎΡΠ΅Π½ΡΠΈΠΎΡΡΠ°Ρ IPC-Pro L (ΠΠΠ€ Β«ΠΠΎΠ»ΡΡΠ°Β») Π±ΡΠ» ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ Π΄Π»Ρ Π·Π°ΠΏΠΈΡΠΈ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠ΅ΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΠΎΡ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ. ΠΡΠ΅ΠΌΡ ΡΠ΅Π³ΠΈΡΡΡΠ°ΡΠΈΠΈ ΡΠΎΡΡΠ°Π²Π»ΡΠ»ΠΎ 15 ΠΌΠΈΠ½.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ Π² Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π°Ρ
Π²Π΅Π»ΠΈΡΠΈΠ½ ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° Π΄Π»Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΡΠ΄Π΅ΠΉ ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΠΏΠΎΡΠΊΠΎΠΉ ΠΈ ΠΏΠ΅ΡΠ΅Π½ΡΡ. ΠΠΎΠ»Ρ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
Π²Π΅Π»ΠΈΡΠΈΠ½ ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠ², ΡΠΎΠ²ΠΏΠ°Π΄Π°ΡΡΠΈΡ
Ρ Π²Π΅Π»ΠΈΡΠΈΠ½Π°ΠΌΠΈ, Π½Π°Ρ
ΠΎΠ΄ΡΡΠΈΠΌΠΈΡΡ Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
Π΄ΠΎΠ²Π΅ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»Π° ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠ² ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΡΠ΄Π΅ΠΉ, ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 12% Π΄Π»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠΎΡΠΊΠΎΠΉ ΠΈ 10% Π΄Π»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠ΅ΡΠ΅Π½ΡΡ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΠ΅ Π² Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π²Π΅Π»ΠΈΡΠΈΠ½ ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΠΏΠ»Π°Π·ΠΌΡ ΠΊΡΠΎΠ²ΠΈ ΠΏΡΠΈ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π΅ ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ ΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ΠΌ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ ΠΏΠΎΡΠ»Π΅ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ. ΠΠ°ΠΉΠ΄Π΅Π½ΠΎ, ΡΡΠΎ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΡΠ»Π΅ΠΊΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π²Π΅Π»ΠΈΡΠΈΠ½ ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΠΏΠ»Π°Π·ΠΌΡ ΠΊΡΠΎΠ²ΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 85,7%, ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ β 69,8%, ΡΠΎΡΠ½ΠΎΡΡΡ β 85,2%.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅: ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Ρ Π²Π΅Π»ΠΈΡΠΈΠ½ ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΠΏΠ»Π°Π·ΠΌΡ ΠΊΡΠΎΠ²ΠΈ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠ΅ Π΄Π»Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ; ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΡΠ²ΡΠ·Ρ ΡΡΡΠ΅ΠΊΡΠ° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠΌΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Ρ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌΠΈ Π²Π΅Π»ΠΈΡΠΈΠ½ ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΠΏΠ»Π°Π·ΠΌΡ ΠΊΡΠΎΠ²ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°; ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½ ΠΊΡΠΈΡΠ΅ΡΠΈΠΉ Π΄Π»Ρ ΡΠ°Π½Π½Π΅Π³ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠ΅ΡΠ΅Π½ΡΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΠ΅Π΄ΠΎΠΊΡ-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° Π² ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅.
Features of the Restoration of Arterial Circulation in Liver Transplantation
Objectives. Violations of tissue blood supply remain one of the most serious complications after
liver transplantation.
Design. To improve the surgical technique of performing reconstructive interventions on the
arteries of the donor and the recipient in order to reduce the frequency of its thrombosis after liver
transplantation.
We studied 25 donors, 20 men and 5 women, the mean age was 56Β± 4 years, eighteen of them
had left aberrant supplementary artery, which in fifteen departed from the left gastric artery and in
three from the aorta above the ventricular stem. Seventeen had the right aberrant artery moving
away from the upper mesenteric artery. Twenty recipients with liver cirrhosis (eleven with primary
biliary cirrhosis, five with primary sclerosing cholangitis, five with viral etiology C cirrhosis, and three
of the lower cirrhosis-cirrhosis disseminated within the Milan criteria. All recipients had standard
anatomical branching of the arteries of the liver. The average age was 50Β±6.
All recipients had standard anatomical branching of the liver arteries. Patients underwent liver
transplantation with new methods of reconstructive interventions on the donor and recipient
arteries.
The developed technique provides the shortest pathway of the recipient's arterial blood to the
liver transplant, through the superior mesenteric artery provides an alternative source of arterial
blood supply from the aorta in which this transplant additionally needs.
Presented method of blood circulation restoration at liver transplantation at abnormal structure
of arterial channel of the liver transplant is performed inside the recipient's abdominal cavity. At first,
blood flow is restored along the reconstructed common hepatic artery, after the right or left aberrant
arteries liver transplant. Such technique provides the shortest route of the recipient's arterial blood
to the liver transplant, through the upper mesenteric artery provides an alternative source of arterial
blood supply from the aorta for which the transplant is additionally needed. This new method of
blood circulation restoration provides an opportunity to avoid the formation of "kinking" syndrome, in
the occurrence of which the blood vessels are lengthened, the angulation and location of the blood
vessel in relation to the grafts and other abdominal organs. This reduces the risk of thrombosis of
the arteries of the transplanted liver
Possibilities for Recovery of Blood Outflow During Thrombosis of the Liver's Own Hepatic Veins in the Early Periods after Transplantation
Orthotopic liver transplantation with preservation of the retrohepatic inferior vena cava (IVC)
using the so-called piggyback technique (MBT) has a number of priorities over the classical
technique.
Since 2006, our Belghiti modified piggyback technique (MPBT) has been used in our center as
a normal procedure for a liver transplantation program and has been performed 490 times by
December 2018. Among them, in 6 recipients in the immediate postoperative period (12- 48 hours),
occlusion of the own veins of the liver graft was noted. In all 6 observations, whole liver was used,
obtained from the donor after ascertaining brain death. The age of these recipients was 32 Β± 12
years, the age of donors was 48 Β± 10 years. Percutaneous stenting was not used to correct the
venous outflow. Re-transplantation due to the absence of a donor organ was not performed.
The best way to treat occlusion of blood outflow from the veins of a liver transplant is to prevent
the very cause of its occurrence. The length of the upper vena cava of the graft must be short
enough to prevent its fracture and redundancy, and the length of the anastomosis must provide a
good venous outflow and be at least 6 cm. segments of the transplanted liver.
The results of our study led to the conclusion that early diagnosis of occlusion of the own veins
of a liver transplant, based on clinical signs and ultrasound diagnostics, allows detecting pathology
in time, reducing ischemic damage to the transplanted organ increases the possibilities of its
recovery