Immunosenescence and CoQ10

The decline of the immune system associated to aging is becoming a global issue nowadays due to the increase of lifespan. Immunosenescence is the deteriorated adaptative capacity of the immune system leading to increase in morbidity and mortality in elderly population. Aging has been related to a progressive affectation of mitochondria such as increase of mtDNA mutation, deregulation of electron transport chain, increase in ROS production and reduction in ATP production. Immunosenescence has been associated with aging associated mitochondrial dysfunction linked to chronic inflammation that induce higher oxidative stress levels and mitochondrial damage deteriorating the already compromised immune system. CoQ10 administration could be considered a beneficial strategy in order to reduce the progression of age-related diseases. Highlighting the important role of CoQ10 on mitochondrial function it has been proposed that this unique antioxidant soluble lipid could be helpful in the management of immunosenescence. High levels of CoQ10 have been related with a delay of immunosenescence attributable to a reduction in DNA damage. Other prolongevity factors, such as caloric restriction and exercise, have been considered for their potential effect in delaying aging effect and immunosenescence mainly affecting mitochondrial physiology and biogenesis and antioxidant activity