Epidemiology and Death-Related Factors of Oncology Patients in Emergency Department

Introduction: Accurate diagnosis and proper treatment of oncology patients presented to emergency department(ED) can dramatically enhance their quality of life and decrease their mortality rate. Therefore, the presentstudy aimed to evaluate these patients from an epidemiologic point of view as well as identifying death-relatedfactors. Methods: In this retrospective cross-sectional study, all the oncology patients presented to ED duringone year were evaluated using census sampling. A checklist that consisted of clinical and demographic data aswell as patients outcome was filled for each patient. Using SPSS 21, multivariate stepwise logistic regressionanalysis was done to identify independent death-related factors. Results: 568 patients with the mean age of53.64§18.99 years were studied (56.5% male). The most common locations of tumor were brain (32.7%) andgastrointestinal tract (27.1%). Pain (32.5%) was the most frequent chief complaint on ED arrival. The overallmortality rate of studied patients was 154 (27.1%), 25 (16.2%) of them in ED. Among the evaluated factors,marital status, visiting on a weekday, arrival to ED via ambulance, type of cancer, stage of cancer, presence ofmetastasis, being under treatment with chemo-radiotherapy, chief complaint on arrival, tumor location, andadmission to intensive care unit (ICU) correlated significantly with in-hospital mortality. Conclusion: The mostcommon type of cancer in the studied patients was solid, located in the brain or gastrointestinal tract, in stage IIIand IV, metastatic, and under chemo-radiotherapy. Independent death-related factors included ICU admission,presentation with loss of consciousness or bleeding, arrival via ambulance, cancer stage > II, neuroendocrineand genitourinary location of cancer, and being under chemo-radiotherapy

Effective Treatment of Cervical Lymph Node Metastasis of Breast Cancer by Low Voltage High-Frequency Electrochemotherapy

Electrochemotherapy (ECT) is a new local treatment method for solid and superficial tumors. During this new technique, patients experience an unpleasant sensation and slight edema. Most unpleasant and painful is mainly attributed to muscle contractions provoked by high amplitude and low repetition frequency pulses. Recently, we showed that electrochemotherapy using low voltage and higher repetition frequency (LVHF ECT) is an effective tool for inhibiting tumor growth and inducing cell permeabilization. Low voltage high-frequency electrochemotherapy was developed and optimized in vitro and in vivo which and can be used in the clinic. In the present study, we report a case of cervical lymph node metastasis of breast cancer treated by the technique. In our case, LVHF ECT was successful in reducing the size and palliating the symptoms of cervical lymph node metastasis in clinical conditions, whereas other approaches were inefficient. Our electrochemotherapy technique shows good clinical results. However, more studies on this new method are necessary to prove that LVHF ECT can be considered as a standard treatment modality