Risk Management Model in Public Governance in Russia: Regional Aspects

This article is devoted to the problem of risks in the activities of political parties. The importance of risk management is growing in conditions of social tension, which are a characteristic of Russia. The study identified the main risk factors for the ruling United Russia party in the Transbaikal Territory. These include: 1) social tension and poor quality of life; 2) internal migration and urbanization; 3) natural disasters; 4) political instability; 5) protest activity of the population; 6) competition from other political parties. A model is proposed as a conceptual basis for managing political risks in the activities of political parties. Its main components are: subjects and objects, goals, objectives and principles, resources, functions and mechanisms, specific technologies and management tools. Each of the components of the model is concretized in the context of managing political risks in the activities of the regional branch of the United Russia party, taking into account the specifics of the Transbaikal Territory. At the end of the article, it is concluded that this model can be considered as universal (for other regions and parties)

Identification of Escherichia coli K12 YdcW protein as a γ-aminobutyraldehyde dehydrogenase

Abstractγ-Aminobutyraldehyde dehydrogenase (ABALDH) from wild-type E. coli K12 was purified to apparent homogeneity and identified as YdcW by MS-analysis. YdcW exists as a tetramer of 202±29kDa in the native state, a molecular mass of one subunit was determined as 51±3kDa. Km parameters of YdcW for γ-aminobutyraldehyde, NAD+ and NADP+ were 41±7, 54±10 and 484±72μM, respectively. YdcW is the unique ABALDH in E. coli K12. A coupling action of E. coli YgjG putrescine transaminase and YdcW dehydrogenase in vitro resulted in conversion of putrescine into γ-aminobutyric acid

Extra-Curricular Activities as an Important Factor for Developing Subject Qualities of Future Engineers

We examine the need to develop the subjective qualities of students at technical universities based on the analysis of Russian and foreign research on future engineers’ training. We consider the peculiarities of future engineers’ educational process, based on the importance of extracurricular activities in the development of such qualities. The purpose of the study is to test the hypothesis about the effectiveness of developing the subjective qualities of future engineers by involving them in extracurricular activities that were formed at the initial stage. The paper describes a pedagogical experiment that includes three stages. The set of research methods includes analysis, synthesis, comparison, generalization, pedagogical observation, questionnaire survey, testing, conversation, expert assessments, and statistics. We present different directions and types of activities organized within the experimental work with pedagogical support. Besides, we give examples of extracurricular activities that contribute to the successful development and manifestation of the specified personal qualities in students. The paper contains evidence of the effectiveness of extracurricular student activities as a factor in developing subjective qualities

Risks to the Human Rights Advocacy in African Constitutions

This article presents the results of a comparative legal study of the texts of the constitutions of African states with a view to identifying the rules that minimize human rights risks. The research is based on a dialectical approach to the disclosure of legal phenomena and processes using general scientific (systematic and logical methods, analysis and synthesis) and specific scientific methods. African constitutions, in comparison with the constitutions of other states, and in particular European ones, contain a disproportionately large number of rules formalizing special human rights institutions. Typically, these are special councils, human rights commissions (Egypt, Morocco, and Tunisia) or certain categories of the population (three in Egypt, three in Morocco, one in the Central African Republic). In Morocco and Equatorial Guinea, both the Mediator and the Public Defender are established, respectively. The relevance of the study is due to the strategic objectives of creating a secure human rights status of the state, as well as the need to find and update theoretical, methodological, and practical approaches to protecting the rights and freedoms of a human and a citizen. Considering the rules of the African constitutional model of minimizing risks to human right advocacy, objectively in terms of quantity and quality, are considered hyperbolic

Auditory Cortex Responses to Clicks and Sensory Modulation Difficulties in Children with Autism Spectrum Disorders (ASD)

Auditory sensory modulation difficulties are common in autism spectrum disorders (ASD) and may stem from a faulty arousal system that compromises the ability to regulate an optimal response. To study neurophysiological correlates of the sensory modulation difficulties, we recorded magnetic field responses to clicks in 14 ASD and 15 typically developing (TD) children. We further analyzed the P100m, which is the most prominent component of the auditory magnetic field response in children and may reflect preattentive arousal processes. The P100m was rightward lateralized in the TD, but not in the ASD children, who showed a tendency toward P100m reduction in the right hemisphere (RH). The atypical P100m lateralization in the ASD subjects was associated with greater severity of sensory abnormalities assessed by Short Sensory Profile, as well as with auditory hypersensitivity during the first two years of life. The absence of right-hemispheric predominance of the P100m and a tendency for its right-hemispheric reduction in the ASD children suggests disturbance of the RH ascending reticular brainstem pathways and/or their thalamic and cortical projections, which in turn may contribute to abnormal arousal and attention. The correlation of sensory abnormalities with atypical, more leftward, P100m lateralization suggests that reduced preattentive processing in the right hemisphere and/or its shift to the left hemisphere may contribute to abnormal sensory behavior in ASD

СОЦИАЛЬНАЯ ИНФРАСТРУКТУРА АКТУАРНЫХ ПЕНСИОННЫХ РАСЧЕТОВ КАК СРЕДСТВО ПРЕОДОЛЕНИЯ ДЕФИЦИТА БЮДЖЕТА

The article is devoted to the problem of overcoming the lack of funding the revenue side of the Pension Fund of the Russian Federation. The ways of further development of the funded component of future pension payments are proposed in the article. The need to form in regions the adequate social infrastructure which could enable to develop the funded pension systems is specified in the article.В статье рассмотрены вопросы преодоления недостатка источников финансирования доходной части Пенсионного Фонда РФ. Предложены пути дальнейшего развития накопительной составляющей предстоящих пенсионных выплат. Указано на необходимость формирования в регионах соответствующей социальной инфраструктуры, которая смогла бы создать условия для развития накопительной системы пенсионного обеспечения

Nitric Oxide Has a Concentration-Dependent Effect on the Cell Cycle Acting via EIN2 in Arabidopsis thaliana Cultured Cells

Ethylene is known to influence the cell cycle (CC) via poorly characterized roles whilst nitric oxide (NO) has well-established roles in the animal CC but analogous role(s) have not been reported for plants. As NO and ethylene signaling events often interact we examined their role in CC in cultured cells derived from Arabidopsis thaliana wild-type (Col-0) plants and from ethylene-insensitive mutant ein2-1 plants. Both NO and ethylene were produced mainly during the first 5 days of the sub-cultivation period corresponding to the period of active cell division. However, in ein2-1 cells, ethylene generation was significantly reduced while NO levels were increased. With application of a range of concentrations of the NO donor, sodium nitroprusside (SNP) (between 20 and 500 μM) ethylene production was significantly diminished in Col-0 but unchanged in ein2-1 cells. Flow cytometry assays showed that in Col-0 cells treatments with 5 and 10 μM SNP concentrations led to an increase in S-phase cell number indicating the stimulation of G1/S transition. However, at ≥20 μM SNP CC progression was restrained at G1/S transition. In the mutant ein2-1 strain, the index of S-phase cells was not altered at 5–10 μM SNP but decreased dramatically at higher SNP concentrations. Concomitantly, 5 μM SNP induced transcription of genes encoding CDKA;1 and CYCD3;1 in Col-0 cells whereas transcription of CDKs and CYCs were not significantly altered in ein2-1 cells at any SNP concentrations examined. Hence, it is appears that EIN2 is required for full responses at each SNP concentration. In ein2-1 cells, greater amounts of NO, reactive oxygen species, and the tyrosine-nitrating peroxynitrite radical were detected, possibly indicating NO-dependent post-translational protein modifications which could stop CC. Thus, we suggest that in Arabidopsis cultured cells NO affects CC progression as a concentration-dependent modulator with a dependency on EIN2 for both ethylene production and a NO/ethylene regulatory function

Boosting the Power Generation in Wind and Hydro Power Production

When approaching a conventional wind turbine, the air flow is slowed down and widened. This results in a loss of turbine efficiency. In order to exploit wind or water flow power as effectively as possible, it was suggested that the turbine should be placed inside a shroud, which consists of 4 wing-shaped surfaces. Two internal air foils improve the turbine performance by speeding up the flow acting on the turbine blades, two external wings create a field of low pressure behind the turbine, thus, helping to draw more mass flow to the turbine and avoid the loss of efficiency due to flow deceleration. The system accumulates kinetic energy of the flow in a small volume where the smaller (and therefore, cheaper) turbine can be installed. A smaller system can be installed inside the bigger one, which would help to accumulate even more kinetic energy on the turbine. This method implies kinetic energy summation with local flow redistribution. Both experiments and CFD simulations demonstrate a significant increase in velocity and generated mechanical power in comparison to those for a bare turbine

Pediatric bacteremia and CNS infections associated with <i>klebsiella pneumoniae</i>: molecular genetic characteristics and clinical features

Klebsiella pneumoniae is one of the most significant and life-threatening pathogen of nosocomial infections. This opportunistic microorganism can cause infections of the bloodstream, respiratory tract, urinary tract, skin and soft tissues, inflammation of meninges of the brain and spinal cord, leading to elevated hospital mortality. The purpose of our study was a retrospective analysis of molecular genetic characteristics of K. pneumoniae isolated from blood and liquor samples as well as to describe clinical features in bacteremia and CNS infections. According to the results of assessed clinical data, K. pneumoniae isolates were selected from 64 children suffered from surgical pathology (congenital heart defects — 30%, abdominal pathology — 39%, severe combined trauma — 12%) and somatic diseases accompanied by antibacterial and/or glucocorticosteroid therapy — 14%. The minimum suppressive concentrations of antibiotics were determined by the broth micro-dilution method. Carbapenemases were detected by real time polymerase chain reaction. Virulence genes and capsule serotypes K1/K2 were assessed by multiplex PCR. Biofilms were grown using flat-bottomed polystyrene plates, followed by coloring, fixation, elution and data detection. The population diversity was assessed by multilocus sequence typing. Bacteremia and CNS infections associated with K. pneumoniae were fatal in 25% of cases. A substantial portion of the isolates demonstrated the phenotype of extremely drug resistance (XDR) — 43%, the phenotype of multidrug resistance (MDR) was shown in 16% of the isolates. The blaCTX-M cephalosporinase gene was found in 85% of the strains. The main determinant of resistance to carbapenems was the blaOXA-48 gene (33%); the blaNDM gene was detected in 9% of strains. The combination of blaOXA-48 and blaNDM was found in 7% of isolates. The study of biofilm production showed that moderate ability to form biofilms was shown in 61%, strong — 21%, and weak — 15% isolates. Two isolates (3%) did not form biofilms. The virulence genes entB and mrkD were detected in 100% of isolates, ybtS — in 78%. The iutA gene was found in 18% of the strains. Two isolates showed the presence of the kfu gene. Seven isolates belonged to the K2 serotype. 27 different genotypes were found in K. pneumoniae isolates examined. The most common were: ST307 — 21%, ST395 — 12%, ST48 — 7%, ST39 — 6% and ST29 — 6%. Infections of the bloodstream and central nervous system associated with K. pneumoniae have great importance in clinical practice. This microorganism is able to long persist on biotic and abiotic surfaces, has a wide natural and acquired resistance to antibiotics