Possibilities of application of catpca in educational research

In this article we give an overview of the possibilities of the categorical method of principal components as a correct alternative to the widely used classical method of principal components. We view CatPCA as a method of Educational Data Mining and see the further development of this method in pedagogical research

Техническое обслуживание резервуарного парка перевалочной нефтебазы «Таманьнефтегаз»

Объектом исследования является резервуарный парк перевалочной нефтебазы «Таманьнефтегаз». Цель работы - разработка технического обслуживание резервуарного парка перевалочной нефтебазы «Таманьнефтегаз». В процессе исследования проводились анализ и расчет элементов конструкции резервуаров. В результате исследования разработана технология технического обслуживание резервуарного парка перевалочной нефтебазы «Таманьнефтегаз».The object of research is a transshipment tank farm tank farm "Tamanneftegas". The purpose of the work - the development of the technical service the tank farm transshipment tank farm "Tamanneftegas". The study carried out an analysis and calculation design elements reservoirs. The study developed a technology for the technical maintenance of the tank farm transshipment tank farm "Tamanneftegas". Degree of implementation: not yet available

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Modification of titanium implants surface by microarc oxidation in presence of polymeric solutions. The study of immune response

In the present study, we performed the in vitro evaluation of titanium samples with four types of coatings obtained by microarc oxidation (MAO): pure calcium phosphate (CaP), CaP- chitosan, CaP- hyaluronic acid, CaP - polyvinylpyrrolidone coatings. AlamarBlue test and TNFα secretion analysis (ELISA) were performed to investigate the immune response. It was shown that formation of MAO hybrid calciumphosphate coatings increases the biocompatibility of samples. Adding of polyvinylpyrrolidone and hyaluronic acid to the electrolyte solution presumably makes it possible to obtain hybrid coatings with anti-inflammatory properties

Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions

BACKGROUND: Interruption of mature axons activates a cascade of events in neuronal cell bodies which leads to various outcomes from functional regeneration in the PNS to the failure of any significant regeneration in the CNS. One factor which seems to play an important role in the molecular programs after axotomy is the stearoyl Coenzyme A-desaturase-1 (SCD-1). This enzyme is needed for the conversion of stearate into oleate. Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C. RESULTS: In situ hybridization and immunohistochemistry demonstrated a strong up-regulation of SCD at mRNA and protein level in regenerating neurons of the rat facial nucleus whereas non-regenerating Clarke's and Red nucleus neurons did not show an induction of this gene. CONCLUSION: This differential expression points to a functionally significant role for the SCD-1 in the process of regeneration

Identification of regeneration-associated genes after central and peripheral nerve injury in the adult rat

BACKGROUND: It is well known that neurons of the peripheral nervous system have the capacity to regenerate a severed axon leading to functional recovery, whereas neurons of the central nervous system do not regenerate successfully after injury. The underlying molecular programs initiated by axotomized peripheral and central nervous system neurons are not yet fully understood. RESULTS: To gain insight into the molecular mechanisms underlying the process of regeneration in the nervous system, differential display polymerase chain reaction has been used to identify differentially expressed genes following axotomy of peripheral and central nerve fibers. For this purpose, axotomy induced changes of regenerating facial nucleus neurons, and non-regenerating red nucleus and Clarke's nucleus neurons have been analyzed in an intra-animal side-to-side comparison. One hundred and thirty five gene fragments have been isolated, of which 69 correspond to known genes encoding for a number of different functional classes of proteins such as transcription factors, signaling molecules, homeobox-genes, receptors and proteins involved in metabolism. Sixty gene fragments correspond to genomic mouse sequences without known function. In situ-hybridization has been used to confirm differential expression and to analyze the cellular localization of these gene fragments. Twenty one genes (~15%) have been demonstrated to be differentially expressed. CONCLUSIONS: The detailed analysis of differentially expressed genes in different lesion paradigms provides new insights into the molecular mechanisms underlying the process of regeneration and may lead to the identification of genes which play key roles in functional repair of central nervous tissues