34 research outputs found
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The PLATES 2020 Atlas of Plate Reconstructions (500 Ma to Present Day), PLATES Progress Report No. 396-1220
This atlas presents plate reconstructions from 500 Ma to the present-day derived by the PLATES Project, Institute for Geophysics, The University of Texas at Austin. The atlas was made possible through the scientific contributions of many researchers, from UTIG and from other institutions. Their efforts are highly appreciated by the members of the PLATES research team. The atlas was created using the PaleoGIS (paleogis.com) for ArcGIS plate reconstruction software by The Rothwell Group, L.P., and the GPlates (http://www.gplates.org/) plate reconstruction software. For more information, contact [email protected] Project, Institute for Geophysics, The University of Texas at AustinInstitute for Geophysic
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The PLATES 2018 Atlas of Plate Reconstructions (550 Ma to Present Day), PLATES Progress Report No. 394-0219
This atlas presents plate reconstructions from 550 Ma to the present-day derived by the PLATES Project, Institute for Geophysics, The University of Texas at Austin. The atlas was made possible through the scientific contributions of many researchers, from UTIG and from other institutions. Their efforts are highly appreciated by the members of the PLATES research team. The atlas was created using the PaleoGIS (paleogis.com) for ArcGIS plate reconstruction software by The Rothwell Group, L.P., and the GPlates (http://www.gplates.org/) plate reconstruction software. For more information, contact [email protected] Project, Institute for Geophysics, The University of Texas at AustinInstitute for Geophysic
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Present-day Plate Boundaries (poster)
This poster shows present-day plate boundaries. The background image is topography/bathymetry of the world as derived by Smith and Sandwell, 1997. Earthquake epicenter locations were downloaded from NEIC (http://neic.usgs.gov) on Marcy 19, 2010. Volcano locations were downloaded from the Global Volcanism Program (http://www.volcano.si.edu) in June 2009.Institute for Geophysic
FOLDING OF THE MESOZOIC COVER IN SW SOMALIA: A COMPRESSIONAL EPISODE RELATED TO TEH EARLY STAGES OF INDIAN OCEAN EVOLUTION
The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast : an exploratory, hypothesis-generating study
Acinic cell carcinoma (ACC) of the breast is a rare form of triple-negative (that is, oestrogen receptor-negative, progesterone receptor-negative, HER2-negative) salivary gland-type tumour displaying serous acinar differentiation. Despite its triple-negative phenotype, breast ACCs are reported to have an indolent clinical behaviour. Here, we sought to define whether ACCs have a mutational repertoire distinct from that of other triple-negative breast cancers (TNBCs). DNA was extracted from microdissected formalin-fixed, paraffin-embedded sections of tumour and normal tissue from two pure and six mixed breast ACCs. Each tumour component of the mixed cases was microdissected separately. Tumour and normal samples were subjected to targeted capture massively parallel sequencing targeting all exons of 254 genes, including genes most frequently mutated in breast cancer and related to DNA repair. Selected somatic mutations were validated by targeted amplicon resequencing and Sanger sequencing. Akin to other forms of TNBC, the most frequently mutated gene found in breast ACCs was TP53 (one pure and six mixed cases). Additional somatic mutations affecting breast cancer-related genes found in ACCs included PIK3CA, MTOR, CTNNB1, BRCA1, ERBB4, ERBB3, INPP4B, and FGFR2. Copy number alteration analysis revealed complex patterns of gains and losses similar to those of common forms of TNBCs. Of the mixed cases analysed, identical somatic mutations were found in the acinic and the high-grade non-acinic components in two out of four cases analysed, providing evidence of their clonal relatedness. In conclusion, breast ACCs display the hallmark somatic genetic alterations found in high-grade forms of TNBC, including complex patterns of gene copy number alterations and recurrent TP53 mutations. Furthermore, we provide circumstantial genetic evidence to suggest that ACCs may constitute the substrate for the development of more aggressive forms of triple-negative disease