Discrimination and reliability: Equal partners?

A critique of Hankins, M article: How discriminating are discriminative instruments?" Health and Quality of Life Outcomes 2008, 6:3

Fully-Coupled Simulation of Cosmic Reionization. I: Numerical Methods and Tests

We describe an extension of the Enzo code to enable fully-coupled radiation hydrodynamical simulation of inhomogeneous reionization in large $\sim (100 Mpc)^3$ cosmological volumes with thousands to millions of point sources. We solve all dynamical, radiative transfer, thermal, and ionization processes self-consistently on the same mesh, as opposed to a postprocessing approach which coarse-grains the radiative transfer. We do, however, employ a simple subgrid model for star formation which we calibrate to observations. Radiation transport is done in the grey flux-limited diffusion (FLD) approximation, which is solved by implicit time integration split off from the gas energy and ionization equations, which are solved separately. This results in a faster and more robust scheme for cosmological applications compared to the earlier method. The FLD equation is solved using the hypre optimally scalable geometric multigrid solver from LLNL. By treating the ionizing radiation as a grid field as opposed to rays, our method is scalable with respect to the number of ionizing sources, limited only by the parallel scaling properties of the radiation solver. We test the speed and accuracy of our approach on a number of standard verification and validation tests. We show by direct comparison with Enzo's adaptive ray tracing method Moray that the well-known inability of FLD to cast a shadow behind opaque clouds has a minor effect on the evolution of ionized volume and mass fractions in a reionization simulation validation test. We illustrate an application of our method to the problem of inhomogeneous reionization in a 80 Mpc comoving box resolved with $3200^3$ Eulerian grid cells and dark matter particles.Comment: 32 pages, 23 figures. ApJ Supp accepted. New title and substantial revisions re. v

Consumer Preference for Sustainable Tourism Certifications: A Choice Modeling Approach

Certifying tourism businesses as sustainable has been proposed as a means to connect the academic goals of ecotourism to the industry. One obstacle that impedes the development of widely recognized sustainable tourism certifications is the lack of knowledge regarding consumer preferences for these certifications. A better understanding of consumer desires is needed in order to create sustainable tourism certifications that will generate price premiums for certified businesses and thus accelerate the growth of certified businesses. This study uses a stated-preference choice modeling approach to examine consumer preference for sustainable tourism certifications amongst international tourists in Tanzania. Results suggest that certifications that emphasize environmental sustainability are more important to tourists than certifications that emphasize cultural or economic sustainability. Additionally, the more stringent certifications provide relatively little increase in consumer utility. The implications of the findings on the development of sustainable tourism certifications are discussed

Cosmological Radiation Hydrodynamics with ENZO

We describe an extension of the cosmological hydrodynamics code ENZO to include the self-consistent transport of ionizing radiation modeled in the flux-limited diffusion approximation. A novel feature of our algorithm is a coupled implicit solution of radiation transport, ionization kinetics, and gas photoheating, making the timestepping for this portion of the calculation resolution independent. The implicit system is coupled to the explicit cosmological hydrodynamics through operator splitting and solved with scalable multigrid methods. We summarize the numerical method, present a verification test on cosmological Stromgren spheres, and then apply it to the problem of cosmological hydrogen reionization.Comment: 14 pages, 3 figures, to appear in Recent Directions in Astrophysical Quantitative Spectroscopy and Radiation Hydrodynamics, Ed. I. Hubeny, American Institute of Physics (2009

Construction and characterization of a BAC library from a gynogenetic channel catfish Ictalurus punctatus

A bacterial artificial chromosome (BAC) library was constructed by cloning HindIII-digested high molecular weight DNA from a gynogenetic channel catfish, Ictalurus punctatus, into the vector pBeloBAC11. Approximately 53 500 clones were arrayed in 384-well plates and stored at -80°C (CCBL1), while clones from a smaller insert size fraction were stored at -80°C without arraying (CCBL2). Pulsed-field gel electrophoresis of 100 clones after NotI digestion revealed an average insert size of 165 kb for CCBL1 and 113 kb for CCBL2. Further characterization of CCBL1 demonstrated that 10% of the clones did not contain an insert. CCBL1 provides a 7.2-fold coverage of the channel catfish haploid genome. PCR-based screening demonstrated that 68 out of 74 unique loci were present in the library. This represents a 92% chance to find a unique sequence. These libraries will be useful for physical mapping of the channel catfish genome, and identification of genes controlling major traits in this economically important species

Interactions of a Light Hypersonic Jet with a Non-Uniform Interstellar Medium

We present three dimensional simulations of the interaction of a light hypersonic jet with an inhomogeneous thermal and turbulently supported disk in an elliptical galaxy. We model the jet as a light, supersonic non-relativistic flow with parameters selected to be consistent with a relativistic jet with kinetic power just above the FR1/FR2 break. We identify four generic phases in the evolution of such a jet with the inhomogeneous interstellar medium: 1) an initial ``flood and channel'' phase, where progress is characterized by high pressure gas finding changing weak points in the ISM, flowing through channels that form and re-form over time, 2) a spherical, energy-driven bubble phase, were the bubble is larger than the disk scale, but the jet remains fully disrupted close to the nucleus, 3) a rapid, jet break--out phase the where jet breaks free of the last dense clouds, becomes collimated and pierces the spherical bubble, and 4) a classical phase, the jet propagates in a momentum-dominated fashion leading to the classical jet + cocoon + bow-shock structure. Mass transport in the simulations is investigated, and we propose a model for the morphology and component proper motions in the well-studied Compact Symmetric Object 4C31.04.Comment: 66 pages, 22 figures, PDFLaTeX, aastex macros, graphicx and amssymb packages, Accepted, to be published 2007 ApJ

The Role of Medical Language in Changing Public Perceptions of Illness

This study was designed to investigate the impact of medical terminology on perceptions of disease. Specifically, we look at the changing public perceptions of newly medicalized disorders with accompanying newly medicalized terms (e.g. impotence has become erectile dysfunction disorder). Does using “medicalese” to label a recently medicalized disorder lead to a change in the perception of that condition? Undergraduate students (n = 52) rated either the medical or lay label for recently medicalized disorders (such as erectile dysfunction disorder vs. impotence) and established medical conditions (such as a myocardial infarction vs. heart attack) for their perceived seriousness, disease representativeness and prevalence. Students considered the medical label of the recently medicalized disease to be more serious (mean = 4.95 (SE = .27) vs. mean = 3.77 (SE = .24) on a ten point scale), more representative of a disease (mean = 2.47 (SE = .09) vs. mean = 1.83 (SE = .09) on a four point scale), and have lower prevalence (mean = 68 (SE = 12.6) vs. mean = 122 (SE = 18.1) out of 1,000) than the same disease described using common language. A similar pattern was not seen in the established medical conditions, even when controlled for severity. This study demonstrates that the use of medical language in communication can induce bias in perception; a simple switch in terminology results in a disease being perceived as more serious, more likely to be a disease, and more likely to be a rare condition. These findings regarding the conceptualization of disease have implications for many areas, including medical communication with the public, advertising, and public policy

Fundamentals of reservoir surface energy as related to surface properties, wettability, capillary action, and oil recovery from fractured reservoirs by spontaneous imbibition

The objective of this project is to increase oil recovery from fractured reservoirs through improved fundamental understanding of the process of spontaneous imbibition by which oil is displaced from the rock matrix into the fractures. Spontaneous imbibition is fundamentally dependent on the reservoir surface free energy but this has never been investigated for rocks. In this project, the surface free energy of rocks will be determined by using liquids that can be solidified within the rock pore space at selected saturations. Thin sections of the rock then provide a two-dimensional view of the rock minerals and the occupant phases. Saturations and oil/rock, water/rock, and oil/water surface areas will be determined by advanced petrographic analysis and the surface free energy which drives spontaneous imbibition will be determined as a function of increase in wetting phase saturation. The inherent loss in surface free energy resulting from capillary instabilities at the microscopic (pore level) scale will be distinguished from the decrease in surface free energy that drives spontaneous imbibition. A mathematical network/numerical model will be developed and tested against experimental results of recovery versus time over broad variation of key factors such as rock properties, fluid phase viscosities, sample size, shape and boundary conditions. Two fundamentally important, but not previously considered, parameters of spontaneous imbibition, the capillary pressure acting to oppose production of oil at the outflow face and the pressure in the non-wetting phase at the no-flow boundary versus time, will also be measured and modeled. Simulation and network models will also be tested against special case solutions provided by analytic models. In the second stage of the project, application of the fundamental concepts developed in the first stage of the project will be demonstrated. The fundamental ideas, measurements, and analytic/numerical modeling will be applied to mixed-wet rocks. Imbibition measurements will include novel sensitive pressure measurements designed to elucidate the basic mechanisms that determine induction time and drive the very slow rate of spontaneous imbibition commonly observed for mixed-wet rocks. In further demonstration of concepts, three approaches to improved oil recovery from fractured reservoirs will be tested; use of surfactants to promote imbibition in oil wet rocks by wettability alteration: manipulation of injection brine composition: reduction of the capillary back pressure which opposes production of oil at the fracture face