Metallicity of the Fossil Group NGC 1550 Observed with Suzaku

We studied the temperature and metal abundance distributions of the intra-cluster medium (ICM) in a group of galaxies NGC 1550 observed with Suzaku. The NGC 1550 is classified as a fossil group, which have few bright member galaxies except for the central galaxy. Thus, such a type of galaxy is important to investigate how the metals are enriched to the ICM. With the Suzaku XIS instruments, we directly measured not only Si, S, and Fe lines but also O and Mg lines and obtained those abundances to an outer region of ~0.5 r_180 for the first time, and confirmed that the metals in the ICM of such a fossil group are indeed extending to a large radius. We found steeper gradients for Mg, Si, S, and Fe abundances, while O showed almost flat abundance distribution. Abundance ratios of alpha-elements to Fe were similar to those of the other groups and poor clusters. We calculated the number ratio of type II to type Ia supernovae for the ICM enrichment to be 2.9 +- 0.5 within 0.1 r_180, and the value was consistent with those for the other groups and poor clusters observed with Suzaku. We also calculated metal mass-to-light ratios (MLRs) for Fe, O and Mg with B-band and K-band luminosities of the member galaxies of NGC 1550. The derived MLRs were comparable to those of NGC 5044 group in the r<0.1 r_180 region, while those of NGC 1550 are slightly higher than those of NGC 5044 in the outer region.Comment: 11 pages, 7 figures, accepted for publication in PAS

Origin of Thermal and Non-Thermal Hard X-ray Emission from the Galactic Center

We analyse new results of Chandra and Suzaku which found a flux of hard X-ray emission from the compact region around Sgr A$^\ast$ (r ~ 100 pc). We suppose that this emission is generated by accretion processes onto the central supermassive blackhole when an unbounded part of captured stars obtains an additional momentum. As a result a flux of subrelativistic protons is generated near the Galactic center which heats the background plasma up to temperatures about 6-10 keV and produces by inverse bremsstrahlung a flux of non-thermal X-ray emission in the energy range above 10 keV.Comment: to be published in PASJ, v.61, No.5, 200

Nutrient intake, serum lipids and iron status of colligiate rugby players

BACKGROUND: There are two main playing positions in rugby (backs and forwards), which demonstrate different exercise patterns, roles, and physical characteristics. The purpose of this study was: 1) to collect baseline data on nutrient intake in order to advise the athletes about nutrition practices that might enhance performance, and 2) to compare serum lipids, lipoproteins, apolipoproteins (apo), lecithin:cholesterol acyltransferase (LCAT) activity, and iron status of forwards and backs. METHODS: The sporting group was divided into 18 forwards and 16 backs and were compared with 26 sedentary controls. Dietary information was obtained with a food frequency questionnaire. RESULTS: There were significant differences among the three groups. The forwards had the highest body weight, body mass index, percentage of body fat (calculated by sum of four skinfold thicknesses), as well as the highest lean body mass, followed by the backs and the control group. The mean carbohydrate intake was marginal and protein intake was lower than the respective recommended targets in all three groups. The mean intakes of calcium, magnesium, and vitamins A, B(1), B(2), and C were lower than the respective Japanese recommended dietary allowances or adequate dietary intakes for the rugby players. The forwards had significantly lower high-density lipoprotein cholesterol (HDL-C) and HDL(2)-C than the backs and had significantly higher apo B and LCAT activity than the controls. The backs showed significantly higher HDL-C, HDL(3)-C, low-density lipoprotein cholesterol, and apo A-I, and LCAT activity than the controls. Four forwards (22%), five backs (31%), and three controls (12%) had hemolysis. None of the rugby players had anemia or iron depletion. CONCLUSION: The findings of our study indicate that as the athletes increased their carbohydrate and protein intake, their performance and lean body mass increased. Further, to increase mineral and vitamin intakes, we recommended athletes increase their consumption of green and other vegetables, milk and dairy products, and fruits. The forwards showed more atherogenic lipid profiles than the backs, whereas the backs showed not only anti-atherogenic lipid profile, but also showed more atherogenic lipid profile relative to the control group. Additionally, our study showed none of the rugby players experienced anemia and/or iron depletion

Suzaku Observation of HCG 62: Temperature, Abundance, and Extended Hard X-ray Emission Profiles

We present results of 120 ks observation of a compact group of galaxies HCG~62 ($z=0.0145$) with Suzaku XIS and HXD-PIN\@. The XIS spectra for four annular regions were fitted with two temperature {\it vapec} model with variable abundance, combined with the foreground Galactic component. The Galactic component was constrained to have a common surface brightness among the four annuli, and two temperature {\it apec} model was preferred to single temperature model. We confirmed the multi-temperature nature of the intra-group medium reported with Chandra and XMM-Newton, with a doughnut-like high temperature ring at radii 3.3--6.5$'$ in a hardness image. We found Mg, Si, S, and Fe abundances to be fairly robust. We examined the possible ``high-abundance arc'' at $\sim 2'$ southwest from the center, however Suzaku data did not confirm it. We suspect that it is a misidentification of an excess hot component in this region as the Fe line. Careful background study showed no positive detection of the extended hard X-rays previously reported with ASCA, in 5--12 keV with XIS and 12--40 keV with HXD-PIN, although our upper limit did not exclude the ASCA result. There is an indication that the X-ray intensity in $r<3.3'$ region is $70\pm 19$% higher than the nominal CXB level (5--12 keV), and Chandra and Suzaku data suggest that most of this excess could be due to concentration of hard X-ray sources with an average photon index of $\Gamma=1.38\pm 0.06$. Cumulative mass of O, Fe and Mg in the group gas and the metal mass-to-light ratio were derived and compared with those in other groups. Possible role of AGN or galaxy mergers in this group is also discussed.Comment: 29 pages with 9 figures, accepted for publication in PASJ Vol 60, second Suzaku special issu

A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease

Background: Kawasaki disease (KD) is a systemic vasculitis which may be associated with coronary artery aneurysms. A notable risk factor for the development of coronary artery aneurysms is resistance to intravenous immunoglobulin (IVIG) therapy, which comprises standard treatment for the acute phase of KD. The cause of IVIG resistance in KD is largely unknown; however, the contribution of genetic factors, especially variants in immune-related genes, has been suspected. Methods: To explore genetic variants related to IVIG-unresponsiveness, we designated KD patients who did not respond to both first and second courses of IVIG therapy as IVIG-unresponsive patients. Using genomic DNA from 30 IVIG-unresponsive KD patients, we performed pooled genome sequencing targeting 39 immune-related cytokine receptor genes. Results: The single nucleotide variant (SNV), rs563535954 (located in the IL4R locus), was concentrated in IVIG-unresponsive KD patients. Individual genotyping showed that the minor allele of rs563535954 was present in 4/33 patients with IVIG-unresponsive KD, compared with 20/1063 individuals in the Japanese genome variation database (odds ratio = 7.19, 95% confidence interval 2.43-21.47). Furthermore, the minor allele of rs563535954 was absent in 42 KD patients who responded to IVIG treatment (P = 0.0337), indicating that a low-frequency variant, rs563535954, is associated with IVIG-unresponsiveness in KD patients. Although rs563535954 is located in the 3'-untranslated region of IL4R, there was no alternation in IL4R expression associated with the mior allele of rs563535954. However, IVIG-unresponsive patients that exhibited the minor allele of rs563535954 tended to be classified into the low-risk group (based on previously reported risk scores) for prediction of IVIG-resistance. Therefore, IVIG-unresponsiveness associated with the minor allele of rs563535954 might differ from IVIG-unresponsiveness associated with previous risk factors used to evaluate IVIG-unresponsiveness in KD. Conclusion: These findings suggest that the SNV rs563535954 could serve as a predictive indicator of IVIG-unresponsiveness, thereby improving the sensitivity of risk scoring systems, and may aid in prevention of coronary artery lesions in KD patients.ArticlePEDIATRIC RHEUMATOLOGY.17:34(2019)journal articl

Psychotic-like experiences and poor mental health status among Japanese early teens

Epidemiological studies of psychotic-like experiences (PLEs) have reported that people who had PLEs during childhood or adolescence have higher incidences of schizophrenia spectrum disorders or other psychiatric disorders later in life than people who have not had PLEs. Previous work has shown that approximately 15% of children in the city of Tsu had PLEs. In this study, we sought to confirm the prevalence of PLEs in early teens living in Nagasaki and to elucidate the associations between PLEs and other psychopathological items. To this end, we used a self-report questionnaire to sample approximately 5,000 students (aged 12-15 years) in public junior high schools. Similar to the results of previous studies, the prevalence of PLEs was 16.4%. There was a significant association between PLEs and poor mental health status, which was estimated using a 12-item General Health Questionnaire. Moreover, after controlling for confounding factors, we found a significant association between PLEs and a lack of satisfaction with family relationships and several other psychosocial problems. These results suggest that a relatively large proportion of children with PLEs have behavioral, social, or familial problems, which may facilitate future schizophrenic symptoms

Changes of Sympathetic Activity in Patient with Chronic Atrial Fibrillation and Severe Congestive Heart Failure Treated with Biventricular Pacing

The patient was a 64-year-old man with chronic atrial fibrillation with bradycardia. Left ventricular ejection fraction was 34%. He was treated with biventricular pacing. Heart failure improved from NYHA class III to II. Sympathetic nerve activity (SNA. was recorded during 6 minutes of biventricular (BV), right ventricular apical (RVA. and left ventricular (LV. pacing. SNA was significantly lower during biventricular pacing (49.5 ± 4.0/min. compared with RVA (58.8 ±6:9/min, p = 0.016. and LV (63.3 ± 4.3/min, p = 0.002. pacing. BV pacing improves hemodynamics and decreases SNA compared with RVA or LV pacing

Suzaku observation of the metallicity distribution in the intracluster medium of the Fornax cluster

The metallicity distribution in the Fornax cluster was studied with the XIS instrument onboard the Suzaku satellite. K-shell lines of O and Mg were resolved clearly, and the abundances of O, Mg, Si, S and Fe were measured with good accuracy. The region within a 4' radius of NGC 1399 shows approximately solar abundances of Fe, Si and S, while the O/Fe and Mg/Fe abundance ratios are about 0.4--0.5 and 0.7 in solar units. In the outer region spanning radii between 6' and 23', the Fe and Si abundances drop to 0.4--0.5 solar and show no significant gradient within this region. The abundance ratios, O/Fe and Mg/Fe, are consistent with those in the central region. We also measured the Fe abundance around NGC 1404 to be approximately solar, and the O, Ne and Mg abundances to be 0.5--0.7 times the Fe level. The significant relative enhancement of Fe within 130 kpc of NGC 1399 and in NGC 1404 indicates an origin in SN Ia, in contrast to the species O, Ne, and Mg which reflect the stellar metallicity. The mass-to-light ratios for O and Fe within 130 kpc of NGC 1399 are over an order of magnitude lower than those in rich clusters, reflecting the metal enrichment history of this poor cluster.Comment: 13 pages, accepted to PAS

ヒト細胞傷害性γδT細胞は膠芽腫細胞株を殺傷する：膠芽腫患者に対する免疫細胞治療の意義

Glioblastoma (GBM) is a highly aggressive brain tumor for which novel therapeutic approaches, such as immunotherapy, are urgently needed. Zoledronate (ZOL), an inhibitor of osteoclastic activity, is known to stimulate peripheral blood-derived γδT cells and sensitize tumors to γδT cell-mediated killing. To investigate the feasibility of γδT cell-based immunotherapy for patients with GBM, we focused on the killing of GBM cell lines by γδT cells and the molecular mechanisms involved in these cell–cell interactions. Peripheral blood mononuclear cells were expanded in ZOL and interleukin (IL)-2 for 14 days, and γδT cells were enriched in the expanded cells by the immunomagnetic depletion of αβT cells. Gliomas are resistant to NK cells but susceptible to lymphokine-activated killer cells and some cytotoxic T lymphocytes. When the γδT cell-mediated killing of three GBM cell lines (U87MG, U138MG and A172 cells) and an NK-sensitive leukemia cell line (K562 cells) were tested, 32 % U87MG, 15 % U138MG, 1 % A172, and 50 % K562 cells were killed at an effector:target ratio of 5:1. The γδT cell-mediated killing of all three GBM cell lines was significantly enhanced by ZOL and this ZOL-enhanced killing was blocked by an anti-T cell receptor (TcR) antibody. These results indicated that TcR γδ is crucial for the recognition of ZOL-treated GBM cells by γδT cells. Since the low level killing of GBM cells by the γδT cells was enhanced by ZOL, γδT cell-targeting therapy in combination with ZOL treatment could be effective for patients with GBM.博士（医学）・甲第635号・平成27年5月28日© Springer Verlag. The definitive version is available at " http://dx.doi.org/10.1007/s11060-013-1258-4