Binary properties of CH and Carbon-Enhanced Metal-Poor stars

The HERMES spectrograph installed on the 1.2-m Mercator telescope has been used to monitor the radial velocity of 13 low-metallicity carbon stars, among which 7 Carbon-Enhanced Metal-Poor (CEMP) stars and 6 CH stars. All stars but one show clear evidence for binarity. New orbits are obtained for 8 systems. The sample covers an extended range in orbital periods, extending from 3.4 d (for the dwarf carbon star HE 0024-2523) to about 54 yr (for the CH star HD 26, the longest known among barium, CH and extrinsic S stars). Three systems exhibit low-amplitude velocity variations with periods close to 1 yr superimposed on a long-term trend. In the absence of an accurate photometric monitoring of these systems, it is not clear yet whether these variations are the signature of a very low-mass companion, or of regular envelope pulsations. The period - eccentricity (P - e) diagram for the 40 low-metallicity carbon stars with orbits now available shows no difference between CH and CEMP-s stars (the latter corresponding to those CEMP stars enriched in s-process elements, as are CH stars). We suggest that they must be considered as one and the same family and that their different names only stem from historical reasons. Indeed, these two families have as well very similar mass-function distributions, corresponding to companions with masses in the range 0.5 - 0.7 Msun, indicative of white-dwarf companions, adopting 0.8 - 0.9 Msun for the primary component. This result confirms that CH and CEMP-s stars obey the same mass-transfer scenario as their higher-metallicity analogs, the barium stars. The P - e diagrams of barium, CH and CEMP-s stars are indeed very similar. They reveal two different groups of systems: one with short orbital periods (P < 1000 d) and mostly circular or almost circular orbits, and another with longer-period and eccentric (e > 0.1) orbits.Comment: Accepted in Astronomy & Astrophysic

Elemental abundances of intermediate age open cluster NGC 3680

We present a new abundance analysis of the intermediate age Galactic open cluster NGC 3680, based on high resolution, high signal-to-noise VLT/UVES spectroscopic data. Several element abundances are presented for this cluster for the first time, but most notably we derive abundances for the light and heavy s-process elements Y, Ba, La, and Nd. The serendipitous measurement of the rare-earth r-process element Gd is also reported. This cluster exhibits a significant enhancement of Na in giants as compared to dwarfs, which may be a proxy for an O to Na anti-correlation as observed in Galactic globular clusters but not open clusters. We also observe a step-like enhancement of heavy s-process elements towards higher atomic number, contrary to expectations from AGB nucleosynthesis models, suggesting that the r-process played a significant role in the generation of both La and Nd in this clusterComment: 8 pages, 6 figures, accepted for publication in MNRA

The discontinuous nature of chromospheric activity evolution

Chromospheric activity has been thought to decay smoothly with time and, hence, to be a viable age indicator. Measurements in solar type stars in open clusters seem to point to a different conclusion: chromospheric activity undergoes a fast transition from Hyades level to that of the Sun after about 1 Gyr of main--sequence lifetime and any decaying trend before or after this transition must be much less significant than the short term variations.Comment: 6 pages, 1 figure, to be published in Astrophysics and Space Scienc

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction

The binding and contribution of transcription factors (TF) to cell specific gene expression is often deduced from open-chromatin measurements to avoid costly TF ChIP-seq assays. Thus, it is important to develop computational methods for accurate TF binding prediction in open-chromatin regions (OCRs). Here, we report a novel segmentation-based method, TEPIC, to predict TF binding by combining sets of OCRs with position weight matrices. TEPIC can be applied to various open-chromatin data, e.g. DNaseI-seq and NOMe-seq. Additionally, Histone-Marks (HMs) can be used to identify candidate TF binding sites. TEPIC computes TF affinities and uses open-chromatin/HM signal intensity as quantitative measures of TF binding strength. Using machine learning, we find low affinity binding sites to improve our ability to explain gene expression variability compared to the standard presence/absence classification of binding sites. Further, we show that both footprints and peaks capture essential TF binding events and lead to a good prediction performance. In our application, gene-based scores computed by TEPIC with one open-chromatin assay nearly reach the quality of several TF ChIP-seq datasets. Finally, these scores correctly predict known transcriptional regulators as illustrated by the application to novel DNaseI-seq and NOMe-seq data for primary human hepatocytes and CD4+ T-cells, respectively

Treatment outcomes in schizophrenia: qualitative study of the views of family carers

Background: Schizophrenia is a complex, heterogeneous disorder, with highly variable treatment outcomes, and relatively little is known about what is important to patients. The aim of the study was to understand treatment outcomes informal carers perceive to be important to people with schizophrenia. Method: Qualitative interview study with 34 individuals and 8 couples who care for a person with schizophrenia/ schizoaffective disorder. Interviews were transcribed verbatim and analysed by a thematic framework based approach. Results: Carers described well-recognised outcomes of importance, alongside more novel outcomes relating to: Safety (of the patient/others); insight (e.g. into non-reality of psychotic phenomena); respite from fear, distress or pain; socially acceptable behaviour; getting out of the house; attainment of life milestones; changes in personality and/or temperament; reduction of vulnerability to stress; and several aspects of physical health. Conclusions: These findings have the potential to inform the development of patient- or carer- focused outcome measures that take into account the full range of domains that carers feel are important for patients.EUFAM

The Uruguay Round A global general equilibrium assessment

SIGLEAvailable from British Library Document Supply Centre- DSC:3597.9512(CEPR-DP--1067) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

A user's guide to Uruguay Round assessments

SIGLEAvailable from British Library Document Supply Centre-DSC:3597.9512(CEPR-DP--1410) / BLDSC - British Library Document Supply CentreGBUnited Kingdo