Results of a multivariate logistic regression model to predict CM (versus UM) in two diverse patient populations.

*<p>baseline comparator group.</p>**<p>Adjusted odds ratio represents the incremental odds of CM for every unit increase (1 ng/mL) in the ANG-1 level.</p

Optimal cut-off values (95% CI) for each test and sensitivity (SEN), specificity (SPEC), positive likelihood ratio (LR(+)) and negative likelihood ratio (LR(−)) at the chosen cut-off value comparing uncomplicated malaria with cerebral malaria patients.

*<p>significantly different from 1 (p<0.05).</p

Area under ROC curve (AUC) for each test comparing UM with CM patients.

<p>P values are based on the null hypothesis that AUC = 0.5.</p

Comparison of angiopoietin-1 and -2 with TNF in pediatric malaria patients from Uganda.

<p>A. Serum concentrations of angiopoietin-1 (ANG-1), angiopoietin-2 (ANG-2), the ratio of ANG-2∶ANG-1 (RATIO, expressed as log base 10), and tumour necrosis factor (TNF) were measured in 28 healthy controls (HC), 67 uncomplicated malaria (UM) patients, and in 69 cerebral malaria (CM) patients. B. Receiver operating characteristic curves (blue line) were generated for each test to compare CM with UM patients, with the null hypothesis (green line) that area under the curve equals 0.5.</p

Biomarker levels in serum of healthy controls (HC), uncomplicated malaria patients (UM) and cerebral malaria patients (CM) from adult Thai patients and pediatric Ugandan patients.

<p>Values are presented as median (range).</p

Demographic information for adult malaria patients from Thailand and pediatric malaria patients from Uganda; healthy controls (HC), uncomplicated malaria patients (UM) and cerebral malaria patients (CM).

<p>Age and parasitemia are presented as median (range). ^*p<0.05 vs. HC and ^†p<0.05 vs. UM (Kruskal-Wallis test with Dunn's multiple comparison post-test).</p

Comparison of angiopoeitin-1 and -2 levels with TNF in adult malaria patients from Thailand.

<p>A. Serum concentrations of angiopoietin-1 (ANG-1), angiopoietin-2 (ANG-2), the ratio of ANG-2∶ANG-1 (RATIO, expressed as log base 10) and tumour necrosis factor (TNF) were measured in 10 healthy controls (HC), 25 consecutive uncomplicated malaria (UM) patients, and in consecutive 25 cerebral malaria (CM) patients. B. Receiver operating characteristic curves (blue line) were generated for each test to compare CM with UM patients, with the null hypothesis (green line) that area under the curve equals 0.5.</p