Bis(acetato-κ2 O,O′)(4,4′-dimethyl-2,2′-bipyridine-κ2 N,N′)copper(II) monohydrate

In the title compound, [Cu(C2H3O2)2(C12H12N2)2]·H2O, the CuII atom exhibits a distorted octa­hedral coordination geometry, defined by two N atoms from one 4,4′-dimethyl-2,2′-bipyridine ligand and four O atoms from two acetate ligands. In the crystal, O—H⋯O hydrogen bonds are observed between the coordinated carboxyl­ate O atoms and the solvent water mol­ecule

8-[(3,3-Dimethyl­oxiran-2-yl)methoxy­meth­yl]-11-hydr­oxy-2-isopropenyl-5-methyl-12-oxo-1,2,3,12-tetra­hydro­pyrano[3,2-a]xanthen-1-yl acetate

The title compound, commonly known as 14-methoxy­tajixanthone-25-acetate, C28H30O8, was isolated from Emericella variecolor. The central xanthone core is approximately planar (r.m.s. deviation = 0.084 Å). The dihydro­pyran ring adopts a distorted half-chair conformation. The oxirane plane is oriented at an angle of 63.3 (2)° with respect to the phenol group. An intra­molecular O—H⋯O hydrogen bond forms an S(6) ring. In the crystal, mol­ecules are linked into a two-dimensional network parallel to the ab plane by weak inter­molecular C—H⋯O hydrogen bonds

9-Meth­oxy-6a,11a-dimethyl-6a,11a-dihydro-6H-1-benzofuro[3,2-c]chromen-3-ol from Dalbergia oliveri

The title compound, commonly known as (+)-(6aS,11aS)-medicarpin, C16H14O4, was isolated from Dalbergia oliveri and displays a rigid mol­ecule consisting of four fused rings. The benzofuran system is inclined at an angle of 76.49 (2)° with respect to the chroman unit. The compound exists as a polymeric chain arising from inter­molecular O—H⋯O bonding

Salicyl­aldehyde–4-(dimethyl­amino)­pyridine (1/1)

In the title compound, C7H10N2·C7H6O2, the components are linked by an O—H⋯N hydrogen bond. The mean planes of two mol­ecules form a dihedral angle of 78.68 (5)°. The crystal packing exhibits weak non-classical C—H⋯O contacts

11-(3-Chloro-2-hydroxy­prop­oxy)-2,3,9-trimethoxy­chromeno[3,4-b]chromen-12(6H)-one

In the title compound, C22H21ClO8, the rotenoid core is nearly planar (r.m.s. deviation 0.114 Å), with the largest deviations from the least-squares plane being 0.286 (3) and 0.274 (2) Å. An inter­molecular O—H⋯O hydrogen bond links two mol­ecules into a centrosymmetric dimer having an R 2 2(18) ring motif

Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan

The controlled release of diclofenac sodium (DFNa) from a chitosan-oxidized konjac glucomannan (CTS-OKG) polymer film was studied. Konjac glucomannan (KGM) was initially oxidized by sodium periodate and then cross-linked to CTS via imine bonds (–C=N–) to form the new CTS-OKG copolymer. The DFNa loaded CTS-OKG polymers were characterized by Fourier transformed infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). Finally, the release profiles of DFNa from the CTS-OKG polymer matrices were evaluated in a simulated gastrointestinal fluid system comprised of two hours in simulated gastric fluid (SGF; pH 1.2) followed by 24 h in simulated intestinal fluid (SIF; pH 7.4). A 1:2:1 (w/w/w) ratio of CTS:OKG:DFNa prepared at room temperature for 3 hours gave the highest % encapsulation efficiency (EE) of 95.6 ± 0.6 and resulted in a minimal release of DFNa (<1% over 2 h) in SGF (pH 1.2) and a significantly improved sustained release in SIF (pH 7.4) with ~6% and 19% release over 8 and 24 h, respectively), some 15- and five-fold lower than that of the two commercial DFNa preparations, Diclosian and Voltaren. This formulation may be used for further study as a long term intestine controlled release drug model (at least 3 days)

2-[(4-Meth­oxy­benz­yl)imino­meth­yl]phenol

In the title Schiff base compound, C15H15NO2, prepared from 4-meth­oxy­benzyl­amine and salicyl­aldehyde, an intra­molecular O—H⋯N hydrogen bonds influences the mol­ecular conformation; the two aromatic rings form a dihedral angle of 73.5 (1)°. In the crystal, weak inter­molecular C—H⋯O inter­actions link the mol­ecules into chains propagating in [010]

(4S,5S,6S)-4-Hy­droxy-3-meth­oxy-5-methyl-5,6-ep­oxy­cyclo­hex-2-en-1-one

The title compound, C8H10O4, was isolated from culture extracts of the endophytic fungus Xylaria sp. (PB-30). The cyclo­hexenone ring exhibits a flattened boat conformation. In the crystal structure, mol­ecules related by translation along the b axis are linked into chains through O—H⋯O hydrogen bonds. Weak non-classical C—H⋯O contacts are also observed in the structure

Xyloccensin E

The title compound (also known as phragmalin triacetate), C35H42O14, is a phragmalin-type limonoid extracted from X. rumphii. The mol­ecule consists of eight rings with the orthoacetate group bridged at positions 1, 8 and 9. The two five-carbocyclic rings (A 1 and A 2) and the dioxolane ring (G) adopt a distorted envelope conformation. The 1,3-dioxane ring (E) exists in a chair conformation. The six-carbocyclic rings (B and C) exhibit a twisted-boat conformation. The lactone ring has a half-chair conformation and the furan ring is planar (r.m.s. deviation = 0.002 Å). Rings A 1/B, A 2/B, B/C, C/D and C/G are all cis-fused. The two acet­oxy groups attached to ring B and the furan ring attached to the lactone ring are in equatorial positions. The porous crystal packing exhibits voids of 688 Å3 and weak inter­molecular C—H⋯O inter­actions. The absolute configuration was assigned on the basis of literature data

Acanthoic acid

The title compound [systematic name: (1R,4aR,7S,8aS,10aS)-1,4a,7-trimethyl-7-vinyl-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodeca­hydro­phenanthrene-1-carb­oxy­lic acid], C20H30O2, is a pimarane-type diterpene extracted from Croton oblongifolius. There are two independent mol­ecules in the asymmetric unit. In both of these, the six-membered rings A, B and C adopt chair, boat and half-chair conformations, respectively. Rings A and B are trans-fused. The two mol­ecules in the asymmetric unit form O—H⋯O hydrogen-bonded R 2 2(8) dimers. The absolute configuration was assigned on the basis of the published literature on analogous structures