Advances in understanding interferon-mediated immune responses to enteric viruses in intestinal organoids

Interferons (IFN) are antiviral cytokines with critical roles in regulating pathogens at epithelial barriers, but their capacity to restrict human enteric viruses has been incompletely characterized in part due to challenges in cultivating some viruse

Can I have a word please: Strategies to enhance understanding of subject specific language in chemistry by international and non-traditional students

In this paper we discuss the outcomes of our research into effective teaching strategies to enhance understanding of subject specific language by international and non-traditional students. Teaching strategies with an emphasis on improving scientific literacy were trialled over the course of the academic year 2010/11 in foundation level chemistry. The outcomes from this research led to the development of an E-glossary to support the development of subject language understanding. The E-glossary was trialled over the academic year 2011/12. It consists of student generated content (with over 100 contributions) explaining scientific terms and concepts in a variety of ways at an appropriate level for foundation students. The outcomes of this research are considered in relation to the development of scientific literacy and conceptual understanding

Transforming the Field of Family Engagement: Co-designing Research Practices Measures for Ed Justice and Community Wellbeing

Our project — the Family Leadership Design Collaborative (FLDC) — is a national network of scholars, practitioners, and family and community leaders who work to center racial equity in family engagement. We do this by reimagining how families and communities can create more equitable schools and educational systems. We engage in research to develop "next" (beyond current "best")1 practices, measures, andtools to foster equitable toward community wellbeing and educational justice.The FLDC is a participatory design research project (PDR). PDR emerges from design- based research and is an iterative research process that attends to power, relationships, and histories of oppression/resilience through partnering with young people, families, and communities. PDR advances theories of human learning alongside new sets of relations, practices, and tools towardssocial justice and change-making.We do this through a practice of PDR called solidarity-driven co-design. Co- design is a process of partnering and decision- makingthat engages diverse peoples to collectively identify problems of practice and innovate solutions. raceCo- design has the potential to foster change- making that is responsive, adaptive, and equity- oriented.

Strong Concordance Between Transcriptomic Patterns of Spleen and Peripheral Blood Leukocytes in Response to Avian Pathogenic Escherichia coli Infection

Avian pathogenic Escherichia coli (APEC) causes morbidity in chickens and exhibits zoonotic potential. Understanding host transcriptional responses to infection aids the understanding of protective mechanisms and serves to inform future colibacillosis control strategies. Transcriptomes of spleen and peripheral blood leukocytes (PBLs) of the same individual birds in response to APEC infection were compared to identify common response patterns and connecting pathways. More than 100 genes in three contrasts examining pathology and infection status were significantly differentially expressed in both tissues and similarly regulated. Tissue-specific differences in catalytic activity, however, appear between birds with mild and severe pathology responses. Early expression differences, between birds with severe pathology and uninfected controls, in the mitogen-activated protein kinase pathway in PBLs precede spleen responses in the p53 and cytokine-cytokine receptor pathways. Tissue bianalysis is useful in identifying genes and pathways important to the response to APEC, whose role might otherwise be underestimated in importance

Leukocyte transcriptome from chickens infected with avian pathogenic Escherichia coli identifies pathways associated with resistance

Avian pathogenic Escherichia coli (APEC) causes colibacillosis, which is responsible for morbidity and mortality in chickens. Gene expression patterns have previously been demonstrated to differ between chicken populations that are resistant vs. susceptible to bacterial infection, but little is currently known about gene expression response to APEC. Increased understanding of gene expression patterns associated with resistance will facilitate genetic selection to increase resistance to APEC. Male broiler chicks were vaccinated at 2 weeks of age and challenged with APEC at 4 weeks of age. Peripheral blood leukocytes were collected at 1 and 5 day post-infection. Lesions on the liver, pericardium, and air sacs were used to assign a mild or severe pathology status to non-vaccinated, challenged chicks. Ten treatment groups were therefore generated with a priori factors of vaccination, challenge, day post-infection, and the a posteriori factor of pathology status. Global transcriptomic response was evaluated using the Agilent 44K chicken microarray. APEC infection resulted in more up-regulation than down-regulation of differentially expressed genes. Immune response and metabolic processes were enriched with differentially expressed genes. Although vaccination significantly reduced lesions in challenged bird, there was no detectable effect of vaccination on gene expression. This study investigated the transcriptomic differences in host responses associated with mild vs. severe pathology, in addition to the effects of vaccination and challenge, thus revealing genes and networks associated with response to APEC and providing a foundation for future studies on, and genetic selection for, genetic resistance to APEC

Cross-correlation image analysis for real-time particle tracking

Accurately measuring translations between images is essential in many fields, including biology, medicine, geography, and physics. Existing methods, including the popular FFT-based cross-correlation, are not suitable for real-time analysis, which is especially vital in feedback control systems. To fill this gap, we introduce a new algorithm which approaches shot-noise limited displacement detection and a GPU-based implementation for real-time image analysis.Comment: 4 pages, 3 figures, submitted to Optics Letter

Review: The Newsletter of the Literary Managers and Dramaturgs of the Americas, volume 13, issue 1

Contents include: Reading Review (Again), Radical from the Root, Arthur Ballet Recipient of the 2002 LMDA Loessing Award, Notes from the Lunatic Fringe, Regional Reports Info: News and Previews From All Over, Review is Inaugurating a New Section in the Next Issue: Projects-In-Process, and LMDA Prize in Drammatury 2002 The Elliott Hayes Award. Issue editors: D.J. Hopkins, Shelley Orr, Liz Engelman, Madeline Oldham, Jacob Zimmerhttps://soundideas.pugetsound.edu/lmdareview/1026/thumbnail.jp

Concert recording 2019-11-18

[Track 1]. Boutade / Pierre Gabaye -- [Track 2]. Sonata for trumpet and piano, op. 51. III. Finale (Tocatta) / Flor Peeters -- [Track 3]. Concerto [Abridged] / Alexander Artunian -- [Track 4]. Sonata for trumpet and piano. I. Lento, Allegro molto / Eric Ewazen -- [Track 5]. Dance suite from Terpsichore . I. Ballet de Grenoville IV. La Bourre / Michael Praetorius edited and arranged by Allan Dean -- [Track 6]. Quintet no. 1, op. 5. I. Moderato / Victor Ewald -- [Track 7]. Sonata for horn, trumpet and trombone (1922). I. Allegro moderato [Track 8]. II. Andante [Track 9]. III. Rondeau / F. Poulenc

Evaluating the Impact of the Film Food Evolution on Attitudes Towards Genetically Modified Food Crops

This study aimed to evaluate the effects of film intervention on consumer opinion and behaviors regarding genetically modified (GM) foods. Students, faculty, and community members attended a viewing of the documentary Food Evolution at the University of Scranton and were surveyed pre- and post-viewing. Results show participants who completed the survey after watching the film perceive GM foods as more likely to increase the global food supply and less likely to cause problems for health and the environment compared to those who completed the survey prior to watching the film. Participants were more likely to agree there is a scientific consensus about the safety of GM foods after viewing the film, compared to those answering the question before the film. Participants are more willing to support use of genetic modification in agriculture and food post-viewing. As climate change threatens the stability of our food systems, genetic modification technology (GMT) can provide scientists with additional tools for adapting, to continue to feed the world population. The study suggests the documentary, Food Evolution, is an effective tool for helping viewers understand the potential benefits of GM foods and gaining support of using genetic modification in food production