The V109G polymorphism in the p27 gene is associated with endometriosis

Objective: To investigate the prevalence of the p27 gene polymorphism in women with endometriosis.Study design: Transversal case-control study. Genomic DNA was extracted from cells collected from buccal swabs. the p27 V109G polymorphism was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a hospital-based Brazilian population.Results: We analysed the 104 patients and 109 control subjects. the distribution of genotype and allele frequencies of p27 V109G polymorphism was significantly different between the endometriosis cases and healthy women (p = 0.016 and 0.002). Women who had at least one mutated allele presented twofold chances for endometriosis development (OR = 1.9; 95% Cl, 1.120-3.343).Conclusion: the polymorphic variant at codon 109 of the p27 gene seems to be associated with higher risk of endometriosis development. (C) 2009 Elsevier Ireland Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, Pelv Pain & Endometriosis Unit, BR-04039032 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, Pelv Pain & Endometriosis Unit, BR-04039032 São Paulo, BrazilFAPESP: 06.58214-2Web of Scienc