Perfil andrológico de touros nelore criados extensivamente no planalto e no Pantanal sul-mato-grossense.

bitstream/item/56426/1/CT100-lancado.pdfNa publicação: Juliana Corrêa Borges

Taxa de prenhez de vacas Nelore submetidas a protocolos de IATF no Planalto Boliviano.

Os benefícios da utilização de métodos reprodutivos alternativos como a inseminação artificial (IA) tem proporcionado avanços significativos no melhoramento do rebanho bovino mundial, além de permitir o controle de doenças venéreas e diminuição de custos de reposição. São também algumas das vantagens apontadas na utilização desta tecnologia a redução na frequência de genes recessivos indesejáveis e difusão genética de touros comprovadamente superiores para regiões do mundo onde sua criação não seria possível.bitstream/item/56917/1/CT101-lancado.pdfNa publicação: Juliana Correa Borges

Episiotomia: resultados maternos e neonatais precoces do uso seletivo versus generalizado

Overview and aims: Episiotomy is one of the most common procedures in Obstetrics, despite actual scientific evidence does not support its routine practice.The aim of this study was to determine the impact of selective and routine practice of episiotomy in early maternal and neonatal outcomes. Study design:An observational, transversal, descriptive and analytic study was conducted in two public Hospitals in northern Portugal, with different policies for the practice of episiotomy: selective practice (Hospital A) and routine practice (Hospital B). Population: A non-random sampling of convenience of the whole puerperal women whose deliveries was performed in these hospitals during months of July and August 2011 was utilized. A total of 397 women was analyzed, 200 in selective group and 197 in routine group. Methods: Data was collected by consultation of medical records of the puerperal women. Comparison between hospitals was performed with the chi-square test. Results: The groups were similar for the obstetric history, demographic, biometric, pregnancy and labor characteristics. However, gestational age, weight and head circumference of newborns as well as instrumentation rate were significantly higher in selective group. Episiotomy was performed in 72.5% cases of selective group and in 88.8% of routine group (p≤0.001).There wasless perinealsuturing (p=0.001) and a greater number of intact perineum in selective group (p≤0.001), without differences in lacerations type or degree. The routine group presented more frequent early perineal complications and higher pain levels in the first postpartum day (p≤0.001). No differences were found between groups in Apgar scores, neonatal trauma and Neonatal Intensive Care Unit admissions number. Conclusions: The selective use of episiotomy was associated with better early maternal outcomes, with no differences in neonatal morbidity. Thus, the routine practice of episiotomy showed no benefit

Sensory comfort evaluation of wool fabrics by objective assessment of surface mechanical properties

The sensorial comfort is one of the most important aspects of clothing, mainly for next-to-skin garments such as trousers for summer. The perceived comfort of wearers of these garments depends to a great extent on the tactile properties of the fabrics. One of the most important surface characteristics of fabrics is the friction coefficient. Two laboratory equipments were developed to evaluate this parameter, the KES-FB4 module of Kawabata system and the FRICTORQ. In this research are compared the results of the fabric objective measurements of the surface roughness and friction measured using the KES-FB4 (surface tester) and the friction coefficient measured by FRICTORQ equipment, in light-weight wool fabrics

Tumor regression grades: can they influence rectal cancer therapy decision tree?

BACKGROUND: Evaluating impact of tumor regression grade in prognosis of patients with locally advanced rectal cancer (LARC). MATERIALS AND METHODS: We identified from our colorectal cancer database 168 patients with LARC who received neoadjuvant therapy followed by complete mesorectum excision surgery between 2003 and 2011: 157 received 5-FU-based chemoradiation (CRT) and 11 short course RT. We excluded 29 patients, the remaining 139 were reassessed for disease recurrence and survival; the slides of surgical specimens were reviewed and classified according to Mandard tumor regression grades (TRG). We compared patients with good response (Mandard TRG1 or TRG2) versus patients with bad response (Mandard TRG3, TRG4, or TRG5). Outcomes evaluated were 5-year overall survival (OS), disease-free survival (DFS), local, distant and mixed recurrence. RESULTS: Mean age was 64.2 years, and median followup was 56 months. No statistically significant survival difference was found when comparing patients with Mandard TRG1 versus Mandard TRG2 (p = .77). Mandard good responders (TRG1 + 2) have significantly better OS and DFS than Mandard bad responders (TRG3 + 4 + 5) (OS p = .013; DFS p = .007). CONCLUSIONS: Mandard good responders had a favorable prognosis. Tumor response (TRG) to neoadjuvant chemoradiation should be taken into account when defining the optimal adjuvant chemotherapy regimen for patients with LAR

Predictive Response Value of Pre- and Postchemoradiotherapy Variables in Rectal Cancer: An Analysis of Histological Data

Background. Neoadjuvant chemoradiotherapy (nCRT) followed by curative surgery in locally advanced rectal cancer (LARC) improves pelvic disease control. Survival improvement is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. Potential predictive factors for Mandard response are analyzed. Materials and Methods. 167 patients with LARC were treated with nCRT and curative surgery. Tumor biopsies and surgical specimens were reviewed and analyzed regarding mitotic count, necrosis, desmoplastic reaction, and inflammatory infiltration grade. Surgical specimens were classified according to Mandard TRG. The patients were divided as "good responders" (Mandard TRG1-2) and "bad responders" (Mandard TRG3-5). According to results from our previous data, good responders have better prognosis than bad responders. We examined predictive factors for Mandard response and performed statistical analysis. Results. In univariate analysis, distance from anal verge and ten other postoperative variables related with nCRT tumor response had predictive value for Mandard response. In multivariable analysis only mitotic count, necrosis, and differentiation grade in surgical specimen had predictive value. Conclusions. There is a lack of clinical and pathological preoperative variables able to predict Mandard response. Only postoperative pathological parameters related with nCRT response have predictive value.info:eu-repo/semantics/publishedVersio

Role of the RAD51 G172T polymorphism in the clinical outcome of cervical cancer patients under concomitant chemoradiotherapy

INTRODUCTION: Cervical cancer is one of the most common cancers diagnosed in women worldwide. Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. The RAD51 protein is required for meiotic and mitotic recombination and plays a central role in homology-dependent recombinational repair of double-strand breaks (DSBs). Given the functional relevance of the DNA repair system on carcinogenesis, potential associations between genetic polymorphisms of DNA repair genes, cancer risk and response to therapy have been intensively evaluated. This is the first study evaluating the role of the RAD51 G172T genetic variants in cancer prognosis and clinical outcome of cervical cancer patients. MATERIAL AND METHODS: We analyzed RAD51 G172T polymorphism genotypes in cervical cancer patients who underwent a platinum-based chemotherapy in combination with radiotherapy. Genotyping was performed by Taqman™ Allelic Discrimination methodology. RESULTS AND DISCUSSION: Concerning the overall survival rates found using Kaplan-Meier method and Log Rank Test, we observed that the mean survival rates were statistically different according to the patients RAD51 genotypes. The group of patients carrying the T allele present a higher mean survival rate than the other patients (102.3months vs. 86.4months, P=0.020). Using the Cox regression analysis, we found an increased overall survival time for T-carrier patients, when compared with GG genotype, with tumor stage, age and presence of lymph nodes as covariates [hazard ratio (HR), 0.373; 95% CI, 0.181-0.770; P=0.008]. Among patients (n=193), RAD51 genotype frequency distributions were not under the influence of clinicopathologic characteristics, namely, treatment response (P=0.508), recurrence (P=0.150) and tumor stage (P=0.250). CONCLUSIONS: This is the first study evaluating the role of the RAD51 G172T genetic variants in cancer prognosis and clinical outcome of cervical cancer patients. Our results indicate an influence of the RAD51 genetic variants in overall survival of cervical cancer. Thereby, RAD51 G172T genotypes may provide additional prognostic information in cervical cancer patients who underwent cisplatin-based chemotherapy in combination with radiotherapy

Permanent Junctional Reciprocating Tachycardia: an Incessant Tachycardia in Children

A taquicardia juncional recíproca permanente é uma forma de taquicardia supraventricular de reentrada pouco comum, embora constitua a causa mais frequente de taquicardia incessante em crianças. O seu carácter permanente causa disfunção ventricular esquerda e miocardiopatia dilatada e é de difícil controlo terapêutico. Objectivo: Rever as características clínicas mais significativas desta arritmia, a sua evolução e as opções terapêuticas actuais. Métodos: estudo retrospectivo, analisando a forma de apresentação e evolução, com particular relevo para a resposta à terapêutica farmacológica e alternativas terapêuticas. Doentes: Grupo de 5 doentes com o diagnóstico de taquicardia juncional recíproca permanente. Resultados: As crianças estudadas tinham idades compreendidas entre os 14 dias e os 12 anos. Três encontravam-se assintomáticas. O primeiro ecocardiograma demonstrou dilatação do ventrículo esquerdo e diminuição da fracção de encurtamento em uma das crianças. A terapêutica farmacológica foi inicialmente eficaz em todos os casos. Ao longo do seguimento (0,2-4,5 anos) a arritmia tornou-se refractária em um dos casos, pelo que se procedeu a ablação da via anómala por radiofrequência. Conclusões: A taquicardia juncional recíproca permanente tem diversas formas de apresentação. A terapêutica farmacológica é recomendada, mas tem carácter transitório. A ablação por radiofrequência é o tratamento definitivo, estando condicionada pela idade dos doentes